vincent aucagne

Synthetic organic chemist and chemical biologist @CNRS
@CBM_UPR4301

[GFPPnews - The French Peptide Society @GFPP_news]

Save the date!
We have the great pleasure to annonce the  French-Italian Joint Meeting GFPP24 organized by the French and Italian Peptide and Protein Societies from June 22nd to 26th, 2025 in Aussois (France). For more details, please visit the website: https://t.co/u7RMwywR7g

[Ivan Ahel Lab @IvanAhelLab]

Our laboratory is looking for a postdoc with expertise in protein biochemistry and structural biology to work on novel pathways regulated by ADP-ribosylation of nucleic acids. Please RT.

[Marcin J. Suskiewicz @MSuskiewicz]

Our team in Orléans (France) is looking for a new postdoc, to work closely with a research associate, Ibtissam Talhaoui, on a project focused on potential SUMO E3 ligases targeting the nucleosome. The details here: https://t.co/CM3poCelab

[Carlo Pifferi @PifferiCarlo]

Nous recherchons un(e) étudiant(e) en Master 2 motivé(e) pour un stage de recherche de 6 mois, avec possibilité de prolongation en contrat de doctorat.
Rejoignez une équipe dynamique à l'interface entre la chimie et la biologie. Envoyez votre candidature dès maintenant!

[Marcin J. Suskiewicz @MSuskiewicz]

@IvanAhelLab @vvinz See this parallel study as well https://t.co/yTUFvT7u5c

[Marcin J. Suskiewicz @MSuskiewicz]

A new paper from @IvanAhelLab about enzymes that efficiently ubiquitylate DNA and RNA in vitro and maybe in cells. With contribution from Orléans by @vvinz and a little bit myself. Part of a larger project on noncanonical Ub by DELTEX E3 ligases led by Kang Zhu as the 1st author.

[Ivan Ahel Lab @IvanAhelLab]

TWO postdoc positions available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in biochemistry/structural biology/cell biology to work on these exciting projects!
Post 1: DNA damage response https://t.co/fec4bdGJtD

[Carlo Pifferi @PifferiCarlo]

We have a 3-year, fully-funded PhD position available from October 2024. If you’re a motivated chemist interested to work at the interface of chemistry and biology do not hesitate to apply! The deadline is April the 10th, so don’t wait the last minute! #academicjobs #PhDposition

[Académie des sciences @AcadSciences]

🗞️ #Communiqué | Dépenses de recherche scientifique
https://t.co/FgxnFDGNUe

[vincent aucagne @vvinz]

Very happy to share the preprint of our talented PhD student El hadji Cisse @CBM_UPR4301 : A straightforward method to prevent the under-estimated problem of aspartimide formation during chemical ligation-mediated protein synthesis https://t.co/PkK4owjKXo #peptide #NCL

[ChemRxiv Bio and Med Chem @chemRxivBiochem]

A straightforward method to prevent the under-estimated problem of aspartimide formation during chemical ligation-mediated protein synthesis
https://t.co/mCo0yaNhJf
#chemrxiv_biochem

[vincent aucagne @vvinz]

@Cochrane_lab Also, be aware that phosphonium-based coupling agents (like PyAOP) react with phenols. Not aminium-based ones (like HATU).

[vincent aucagne @vvinz]

@Cochrane_lab Free phenols are usually not a problem (but I never worked with dopamine), but phenolic esters are stable to TFA cleavage. In the case of 2-hydroxy-5-nitrobenzyl and 2-hydroxy-4methoxybenzyl (Hmb backbone amide protecting group), a piperidine treatment cleaves the esters.

[vincent aucagne @vvinz]

@MolletLucile @dorian_mcilroy 10 peptides synthétiques ciblant 5 antigènes tumoraux (Antigène Carcino-embryonnaire (ACE), Récepteur 2 du Facteur de croissance Epidermique Humain (HER-2), Antigène A2 du Mélanome (MAGE-2), Antigène A3 du Mélanome (MAGE-3), Tumeur Protéine 53 (P53))

[Bode Group @bode_lab]

Every peptide chemist will tell you that C-terminal amides are more stable than C-terminal acids. It turns out that is completely wrong for intracellular proteins! A fantastic collaboration with @jcornlab, @matthias_muhar, @jakobfarnung

[vincent aucagne @vvinz]

@livesinchem @ProfDaveLeigh @UoMChemistry @sirfrasersays Happy birthday Dave !

[Carlo Pifferi @PifferiCarlo]

Happy to share this fresh preprint @ChemRxiv on a collaborative effort between @CBM_UPR4301 and @Servier ...and it is also my first work as a co-corresponding author! 🤩
Free to read👉 https://t.co/8DMjPVumqc

[ChemRxiv Bio and Med Chem @chemRxivBiochem]

N-terminal cysteine as minimalistic handle for dual, site-selective bioconjugation: application to an anti-HER2 affibody reveals synergy of two conjugated drugs
https://t.co/5w7OSHdDE4
#chemrxiv_biochem

[vincent aucagne @vvinz]

Highly recommended: smart and kind supervisor, amazing project.

[Marcin J. Suskiewicz @MSuskiewicz]

We have a PhD position to work on protein SUMOylation using a mixture of approaches, funded by our ERC Starting Grant. Orléans is a beautiful medium-sized city on the Loire, not far from Paris. I'll do my best to make it a good experience.

[Marcin J. Suskiewicz @MSuskiewicz]

We have a PhD position to work on protein SUMOylation using a mixture of approaches, funded by our ERC Starting Grant. Orléans is a beautiful medium-sized city on the Loire, not far from Paris. I'll do my best to make it a good experience.