@weitinglu.bsky.social

Tea addict and scientist, in that order.
Group Leader, Dept of Oncology, University of Oxford. All views my own.

[Cancer Cell @Cancer_Cell]

Whole-genome doubling drives immune evasion by silencing antigen presentation https://t.co/Bi5byznLXo

[Peter Ly @PeterLyLab]

Chromosome loss is detrimental to cellular fitness, yet can be an early event in cancer. How can a deleterious genomic alteration initiate tumorigenesis? 🤔

Our latest preprint tackles this paradox using clear cell renal cell carcinoma (ccRCC) as a model.
https://t.co/jdoiAyYMmo

[Peter Ly @PeterLyLab]

Excited to share our latest paper, out today @CellCellPress. We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. (1/7)

https://t.co/SbshGhofN0

[@weitinglu.bsky.social @Wtlu3]

Congrats Roberto! One of my favorite projects combining genomic instability, RNA biology and cancer!!

[Roberto Vendramin @RobertVendramin]

We’re thrilled to see our work featured on the cover of the May issue of @ImmunityCP! https://t.co/jc5eZvqFme 🧵(1/5)

[@weitinglu.bsky.social @Wtlu3]

@SonyaHessey @CharlesSwanton @Nature Well done Sonya, Mariam, Charlie and team!! It's a massive undertaking that takes many years!! Congrats 🎉 🎉

[Sonya Hessey @SonyaHessey]

Thrilled that our manuscript ‘Evolutionary characterization of Lung Cancer metastasis’ in #TRACERx & #PEACE was published in @Nature today. Here is a summary:

[Charles Swanton @CharlesSwanton]

Excited to share our ‘Evolutionary characterization of #LungCancer metastasis’ in #TRACERx & #PEACE, published today in @Nature: a decade spanning effort led by the Jamal-Hanjani lab, @SwantonLab, @NickyMcGranahan & @ZaccaSimo at @uclcancer & @TheCrick. Link below

[Roberto Vendramin @RobertVendramin]

This paper supports a major conceptual shift: tumour antigens are not restricted to DNA mutations; 𝗥𝗡𝗔 𝘀𝘂𝗿𝘃𝗲𝗶𝗹𝗹𝗮𝗻𝗰𝗲 𝗽𝗮𝘁𝗵𝘄𝗮𝘆𝘀 𝗮𝗰𝘁𝗶𝘃𝗲𝗹𝘆 𝘀𝗵𝗮𝗽𝗲 𝘄𝗵𝗮𝘁 𝘁𝗵𝗲 𝗶𝗺𝗺𝘂𝗻𝗲 𝘀𝘆𝘀𝘁𝗲𝗺 𝗰𝗮𝗻 𝘀𝗲𝗲. (12/16)

[Iva Tolić @Toliclab]

Chromosomes stuck behind the spindle are ticking time bombs for aneuploidy. We uncovered a mechanical rescue mechanism where microtubule pivoting repositions these high-risk chromosomes! Out last week in @NatureComms, here's a thread 🧵

https://t.co/BBLyswTXK9

[Martina Hallegger @martinahallegg1]

Join the Hallegger Lab in Oxford! A RA position is available to develop neuronal cell models to characterise TDP-43 feedback loops.
Highly collaborative project funded by the MND Association.
Please repost and share widely!

https://t.co/rbq3eQfcGn

[Anirban Maitra @Aiims1742]

Could it be this easy? I am not sure to be honest - although it would be nice!
Anyone running this trial?

Combination of PARP and KRASG12D inhibitors enhances therapeutic efficacy by exploiting vulnerabilities in #PancreaticCancer
https://t.co/Gt75BwW18c

[Hallou Lab @Hallou_Lab]

🚨 3-year Postdoc Position @HallouLab (Kennedy Institute, Oxford) - on Spatial Biology & Bioinformatics of Fibrosis🚨

Exciting project combining #SpatialTranscriptomics & #Mechanobiology:

https://t.co/z801pbKEwh

Deadline: 16 March - Please RT 📢!

@KirOxford @UniofOxford

[Jake June-Koo Lee @jakelee0711]

6/n Here are all HLAMP regions in our cohort, classified by two key ecDNA metrics (ecDNA score and mass-in-window). One thing struck me: tissue-type specificity. ecDNA is prevalent in GBM, SCLC, EGFR+ lung cancer, while ovarian and TNBC cases are dominated by ICamps.

[Anirban Maitra @Aiims1742]

Congratulations to Alec Kimmelman & team @nyulangone for @CellCellPress paper today:
Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux
https://t.co/mvXs3PfNbW
In #PancreaticCancer, ECM regulates autophagy flux via the integrinα3-Hippo-YAP1 axis

[Steven Artandi, MD, PhD @SCIDirector]

SCI member @michelle_monje & others reveal that neuronal activity fuels #SCLC growth in both lung and brain via nerve signaling and synaptic connections. Cutting nerve input slows tumors, spotlighting the nervous system's key role in cancer progression. https://t.co/7ubEWLzary

[Itai Yanai @ItaiYanai]

Papers submitted on Tuesdays are more likely to be accepted by Nature whereas Wednesdays seem the most likely day to submit and secure acceptance to PLOS ONE. For Cell, Mondays and Tuesdays seem the best submission days in case of accepted papers.
https://t.co/6w5AraWMzG

[Wei-Yu Lu @WeiYu_Lu]

A paper from our lab!
https://t.co/vGgoXclP3S
In this paper, we show that Treg determines efficiency of bile duct regeneration, unpicking PSC pathogenesis. Thanks to the support from @The_MRC and the PSC Partners Seeking A Cure , and @PSCPartnersCa

[Anirban Maitra @Aiims1742]

Two fantastic stories published ~a year apart with striking confluence in findings - while age is the single most important risk factor for cancer, aging can also limit the ability of cells to undergo neoplastic transformation.
https://t.co/k3A4nvttVn
https://t.co/fNiXBr14tp

[@weitinglu.bsky.social @Wtlu3]

We are hiring a postdoc! Are you:
🔥Passionate about genomic and chromosomal instability?
❓Curious about the relationship between whole genome doubling, cancer evolution and drug resistance?
🩺Want to have close collaboration with clinical facing groups?
https://t.co/mYwOOJhFaM

[@weitinglu.bsky.social @Wtlu3]

@LoiSher @FAndreMD @DrChoueiri Congratulations Sherene !! Mindblowing discovery!🤯🤯🤯