Zoya

PhD student in Prof. Alpha Yap's lab @IMBatUQ🔬Studying mechanobiology of apoptotic extrusion in epithelia

[Zoya @zoya_mannn]

Thank you @EpiMechFC for posting this thread on the fascinating work we do in the Yap lab @IMBatUQ!👇

[epithelial mechanics fan club @EpiMechFC]

How do epithelial monolayers respond to apoptotic cells? What happens to these cells within hypertensile epithelia? More importantly, what is hypertensile epithelia and what leads to it?

I am @zoya_mannn and I will talk about epithelial mechanics of apoptotic cell extrusion.

[Hao Yin @HaoYin20]

KnockTF: a comprehensive human gene expression profile database with knockdown/knockout of transcription factors

Now KnockTF 2.0 👤🐭🌱🌽

>1400 transcriptomes
~800 TF/TcoF
https://t.co/UW8yBf5lzk

Go to "Search" for your TF
"Quick Search" does not work

@NAR_Open 2020
https://t.co/Kr5VkVPNSv

[Cell Reports @CellReports]

PIEZO1-dependent mode switch of neuronal migration in heterogeneous microenvironments in the developing brain https://t.co/dgPdIIiRMp

[Rashmi Priya @rashmi-priya.bsky.social @_Priya_R]

Stoked to present our latest, brilliantly led by Chris et al & Alejandro Torres-Sanchez. How tissues are patterned during development – we found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n https://t.co/jgXSglGpAj

[Sharad Kumar @molregulation]

Really cool study showing that EVs shed from pyroptotic cells contain gasdermin pores that, when fused to other cells, cause bystander cell death.

Transplantation of gasdermin pores by extracellular vesicles propagate... https://t.co/w3RwWjZ570

[Tetsuhisa Otani @tetsuotani1]

Together with an accompanying preprint by @LevayerR that shows that interfacial tension or growth are sufficient to drive mechanical cell competition, these results establish the importance of interfacial tension in mechanical cell competition. (11/n)
https://t.co/BEJlBbXz5Q

[Tetsuhisa Otani @tetsuotani1]

New preprint from the lab! We show that epithelial cells lacking ZO-1/ZO-2, the key scaffolding proteins of tight junctions, are eliminated when surrounded by normal cells. (1/n)
https://t.co/L0l1tavJBd

[Zoya @zoya_mannn]

@Ravi_raj_singh1 @Biomed_MDPI @MDPIOpenAccess Thanks @Ravi_raj_singh1!

[Zoya @zoya_mannn]

Been long overdue, but thrilled to share our perspective article, finally online in @Biomed_MDPI @MDPIOpenAccess!
👉 https://t.co/nQNUBfQcvg"

[Tapomoy Bhattacharjee @tapomoy89]

Latest work from our group @Esoftbio @NCBS_Bangalore, led by Sree @padmanabh97, is out today in @NatureComms! In colab with @DeepaAgashe @c_kurzthaler we report that the physical confinement acts as a selective pressure on bacterial growth in 3D! [1/16]
https://t.co/VErWWENCL9

[epithelial mechanics fan club @EpiMechFC]

How do cells orchestrate themselves to achieve a directional movement as a group?

Hi, I’m @SayukiHirano in @kazuhiroaokilab. In this thread, I’ll highlight key mechanisms of how cells communicate with each other to perform directional collective migration.

[Ulrich Schwarz (also @ulrichschwarz.bsky.social) @SchwarzUlrich]

📢Actin alert 📢

Recent all-atom molecular dynamics simulations from the group of Gregory Voth published in @BiophysJ suggest that actin filaments under force form microcracks, which lead to new binding interfaces for the mechanosensitive proteins from the LIM domain family. I have written a "New and Notable" on this and here is a share link valid until Nov 2: https://t.co/SijRMp731p

[Zoya @zoya_mannn]

Congrats @Bageshri_N! This beautiful piece of work finally out!!

[A/Prof Samantha Stehbens PhD @SamStehbens]

Excited to announce…..it’s finally arrived (!!) https://t.co/eglUVvKFgW
A big thank-you to my team (particularly @robertr33), co authors & #FutureFellowship funding from @arc_gov_au
Importantly- a big shoutout to @drDJVDavid @NatureCellBio for their support. 👇tweetorial 👇 #VivaLaMicrotubules 🎉

[Zoya @zoya_mannn]

Thanks @onenimesa and @JuliaEckert10 for running this remarkable network. Congrats @EpiMechFC for turning one this year! Looking forward to many more cool threads soon..

[epithelial mechanics fan club @EpiMechFC]

Hi fellow researchers, I am @zoya_mannn, PhD student in Alpha Yap’s group @IMBatUQ.
I’m interested in understanding mechanobiology of epithelial cells- how dead cells are eliminated from epithelial tissue via extrusion & their driving mechanistic forces.

[Zoya @zoya_mannn]

Yet another insightful thread by @JuliaEckert10 !

[epithelial mechanics fan club @EpiMechFC]

How can we use cell shapes and geometry to study mechanics of tissues?

I'm @JuliaEckert10 and with this thread I would like to show you the secrets of cells and tissues. Let’s connect biology with a little bit of physics. Don't be scared and get inspired 😀. #EpithelialMechanics

[Shrinivas Bishu @IBDimmunology]

1/3 @eamonnquigleymd this study is awesome.

⏺️Some genes = ⬆️ risk for IBD
⏺️ key risk gene = ⬆️ ETS2
⏺️ETS2 = KEY inflammation gene

▶️ETS2 = ⬆️ inflammatory IBD genes in macs

🟢ETS2 can be blocked = New tx? = WOW

https://t.co/aqevGcLSG6

Full paper in @nature in 2/3 👇

[epithelial mechanics fan club @EpiMechFC]

Hi I’m @vp_mechbio, intrigued by how cells regulate their shape, by means of cytoskeleton and how this influences cellular function. One way to study this mechanism is to impose cells to certain geometric shape. Allow me to welcome you to the world of micropatterning!

[Min WU @WUMIN_LAB]

😍 " moment of the entry of Lipofectamines into the cell via endosome-rupture"

So many wonderful cell biology ideas behind how John Heuser captured these rare, transient, asynchronous moments. Read them here:

early #EM_Monday @HaniehFalahati
https://t.co/Zoc6DdGzyu

[Zoya @zoya_mannn]

@DedenonMathieu @EpiMechFC @RosenblattLab interesting thought @DedenonMathieu. Transformed/live cells extrude first and die by anoikis later(@RosenblattLab work), and those 3 extrusion types seem to share S1P pathway, but it's still vastly unexplored!