Alessandro Prigione

Stem Cell Metabolism lab. Using iPSCs to search for cures for rare mitochondrial diseases. Editor-in-Chief of Stem Cell Research. @[email protected]

[International Society of Organoid Research @the_ISoOR]

The Impact of Mutant #Huntingtin on Neurodevelopment Unveiled through Human #Brain #Organoid Models. #BrainOrganoid
By Pawel Lisowski，Selene Lickfett，@AlePrigio，et al.
More Brain Organoids Research Highlights: https://t.co/N7mF2ctvpP
Article Link: https://t.co/a8BSE3nELG

[The Journal of Inherited Metabolic Disease @JIMD_Editors]

Next up in the modelling IEM session, Dr @AlePrigio discusses developing brain organoid models for the study of #mitodisease. In addition to developing robust models, he has begun working on drug repurposing

#excitingstuff #raredisease #SSIEM2024
(not brains in jars)

[Alessandro Prigione @AlePrigio]

Beautiful run this morning for the Kastelo charity run. Thanks to the SSIEM2024 organizers! @ssiem2024_Porto

[Alessandro Prigione @AlePrigio]

@DykstraWerner Thank you Werner for your excellent work!

[Alessandro Prigione @AlePrigio]

@DeRubeisLab Thanks!

[Alessandro Prigione @AlePrigio]

It's out! Excited to share our latest work in Nat Comms.
We found that mutant Huntingtin impairs human neurodevelopment in brain organoid models through early disregulation of the mitochondrial protein CHCHD2.
Thanks to all coauthors!
https://t.co/az3UDiVzEK

[Alessandro Prigione @AlePrigio]

@ONEResearchComm Thanks!

[Alessandro Prigione @AlePrigio]

@Mito_Therapy Thanks Dario!

[Alessandro Prigione @AlePrigio]

@Pluchinolab Thanks Stefano!!

[Alessandro Prigione @AlePrigio]

@AleParziAle Thank you Ale!!

[Alessandro Prigione @AlePrigio]

@KajasteLab Thanks so much Anna!

[Alessandro Prigione @AlePrigio]

@CarmeloFerrai Thank you so much Carmelo!! It has been such a long project (as you may remember..).

[Alessandro Prigione @AlePrigio]

@KurianLab Thank you Leo!

[Alessandro Prigione @AlePrigio]

@FrezzaLab Thanks Christian!

[Alessandro Prigione @AlePrigio]

@TheVilchezLab Congratulations David and all the team!

[Alessandro Prigione @AlePrigio]

@TheVilchezLab Thanks David!

[Alessandro Prigione @AlePrigio]

@Dpla_ Thank you David!

[Max Delbrück Center @MDC_Berlin]

Researchers at @MDC_Berlin and @HHU_de have identified a gene that affects mitochondria in an #organoid model of #Huntington’s disease. The gene may contribute to brain abnormalities much earlier than previously thought. @NatureComms @metzgerlab @AlePrigio
https://t.co/5rgXhn5PrA

[Alessandro Prigione @AlePrigio]

This was quite a long project starting several years ago and a huge collaborative efforts! Mainly with @HHU_de and @MDC_Berlin but also other labs in Germany, Greece and Spain!
Great collaboration with co-last author @metzgerlab. And thanks to funding from @dfg_public

[Alessandro Prigione @AlePrigio]

Great collaboration with Antonio del Sol, @OlePless, Christine Rose, @eperlste and many others. Grateful to the support from @BMBF_Bund and @EJPRareDiseases, European Commission, @cure_mito, @UMDF, PALS, and Mito Help!

[Alessandro Prigione @AlePrigio]

Delighted to share our latest preprint! We used iPSC-derived brain organoids and deep learning screenings to identify new drugs to treat the mitochondrial disease Leigh syndrome.
Graduate student Carmen Menacho received a Merit Award for this #ISSCR2024.
https://t.co/UkThzp1JR1