Approximately 30% of HER2+ breast cancers harbor PIK3CA mutations. In this interesting report just published in @ESMO_Open, gedatolisib + trastuzumab yielded an ORR of 43% and PFS 6 months for pretreated, PIK3CAm, HER2+ MBC. Key toxicity: stomatitis. https://t.co/vrsXZA9JgS
"How do we actually help people and communicate in real time?" Systems focused on patient-reported outcomes aim to provide more responsive care for cancer symptoms and side effects. https://t.co/eGNjS9Epd4 @jillfeldman4@paspears88
The Biomarker Qualification Program has not consistently delivered on its promise. Friends of Cancer Research outlined three recommendations to modernize the program and improve regulatory clarity. Read the full white paper: https://t.co/6IQ61868Lj.
Patients remained at the center of many discussions during the HIMSS AI in Healthcare Forum in Boston.
Throughout the event, speakers explored how AI can help people navigate care more easily, better manage their health and build confidence as they interact with the healthcare system, while also supporting the clinicians and teams who care for them.
We'll continue exploring these opportunities at the next HIMSS AI in Healthcare Forum in San Diego.
We hope to see you in October: https://t.co/HQuxIRBIU2
We are leading a phase 2 study, called #TRUDI, to test the safety and effectiveness of an investigational drug combination (trastuzumab deruxtecan and durvalumab) to learn if the intervention works in stage III, HER2-expressing #InflammatoryBreastCancer.
👉https://t.co/4hE81lnGss
PI: @FilipaLynce #TDXd #BreastCancer #IBC @IBC_DanaFarber
The #REPDstudy aims to learn how exercise might lower the risk of developing #BreastCancer in women with #DenseBreastTissue by studying changes that occur in breast tissue and blood.
For more information: Call 857-215-2938, Email [email protected] or Visit
https://t.co/qysTdGpD6G
PI: Jennifer Ligibel #BreastCancer #ExerciseOncology
Among US cancer survivors, rates of lifestyle advice from health professionals remained stable 2011–2020, but advice was consistently associated with higher engagement in recommended behaviors. https://t.co/GWU5G937gv
Join @DanaFarber experts for our free #BreastCancerBreakthroughs webinar on 🗓️ Tuesday, June 16th, 4:00–5:00 pm EST.
This is a live webinar discussing the latest advances from #ASCO26 in #BreastCancer treatment, #ctDNA-guided care, and the emerging role of #GLP1 therapies in cancer management. The webinar is geared towards the medical profession but is open to all.
Register today⬇️
https://t.co/qo5UAi1YBm
INSTEAD OF WATCHING AN HOUR OF NETFLIX TONIGHT.
This 1 hour Stanford lecture by Joel Peterson will teach you more about negotiation and getting what you want than most people learn in years.
Bookmark it and give it an hour, no matter what.
Tremendous discussion by @drsarahsam, highlighting the promise of several escalation/substitution strategies across breast cancer subtypes, but reminding the costs and caveat of each new option. #ASCO26
Martine Piccart has crowned giredestrant the new queen 👑 of adjuvant ET! And the 👑 rules across menopausal status:
At #ASCO26, adjuvant giredestrant demonstrated consistent IDFS and DRFI benefit in both pre- and post-menopausal HR+ early breast cancer, with fewer discontinuations due to musculoskeletal pain compared with SOC ET.
#bcsm @OncoAlert
OPTIMA at #ASCO26 met non-inferiority, suggesting many patients with high-risk HR+/HER2- early breast cancer — including premenopausal patients with node-positive disease and low ROR scores — did not derive meaningful benefit from chemotherapy. Important step toward biologically driven de-escalation👏🏼
#bcsm #ASCO2026
@UNC_Lineberger@OncoAlert@OncBrothers
Presented at #ASCO26:
Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: https://t.co/xwLWBZYRzq
@ASCO
Exciting NATALEE update presented today at #ASCO26 (Abstract 501)!
New gene expression analysis from the largest biomarker dataset in any adjuvant CDK4/6i trial shows ribociclib + NSAI iDFS benefit is consistent across all PAM50 subtypes (66% LumA, 28% LumB, 3% HER2E, 3% Basal-like) with no significant interaction.
Subtypes strongly prognostic; trend toward greater benefit in higher genomic risk/proliferation tumors.
Reinforces the broad value of ribociclib + ET in stage II/III HR+ HER2- early breast cancer while advancing precision.