AndréassonLab

We use yeast to understand the molecular mechanisms of cellular protein homeostasis. Account is run by members of the lab.

[AndréassonLab @AndreassonLab]

… aaand the Andréasson lab is finally online!

Make sure to visit our new homepage, where we post about #proteostasis, current projects and #jobopportunities!

https://t.co/lD6pPnlbRQ

[American Society for Cell Biology @ASCBiology]

From MBoC
Genetic inactivation of essential HSF1 reveals an isolated transcriptional stress response selectively induced by protein misfolding

Cells counteract stress by inducing adaptive transcriptional programs. Hsf1 in yeast is solely responsible

https://t.co/q5kOTh3c4L

[AndréassonLab @AndreassonLab]

@_VerenaKohler Thanks! Took some time to get this out, Bpa crosslinking in human cells is not trival...

[AndréassonLab @AndreassonLab]

Our new paper: Misfolded proteins activate HSF1 by releasing it from Hsp70. This has been clear in yeast for some time and we find that the mechanism is similar in human cells. https://t.co/TuLr8q2Ez3

[Verena Kohler @_VerenaKohler]

Latest paper from my former lab- congrats, guys ⁦@AndreassonLab

⁩Protein misfolding releases human Heat Shock Factor 1 (HSF1) from HSP70 latency control https://t.co/tQibrSItZB

[AndréassonLab @AndreassonLab]

Very happy to share our latest findings: A novel chaperone – Chp1 – functions at the ribosomal tunnel to safeguard the biosynthesis of abundantly expressed eEF1A. Great collaboration with @BukauLab
@hauryliuk and many others! https://t.co/CdfFj5dT1O

[Irene Álvarez Guerra @IreneAGuerra]

I'm so happy that the first paper from my PhD is finally published🙊. We define the tethers in the yeast vacuole-lipid droplets #membranecontactsite and their role in microlipophagy. Major thanks to all the people that contributed to make this story happen 😁

[AndréassonLab @AndreassonLab]

Very happy to share our latest findings: A novel chaperone – Chp1 – functions at the ribosomal tunnel to safeguard the biosynthesis of abundantly expressed eEF1A. Great collaboration with @BukauLab @hauryliuk and many others!
https://t.co/JiXpfCJAZN

[BüttnerLab @ButtnerLab]

We are so proud to share the final version of our latest #MembraneContactSites story🎉, now in @Dev_Cell. We identify the LDO proteins and Vac8 as a tethering pair between the vacuole and lipid droplets (vCLIP) that mediates microlipophagy in starvation
https://t.co/jHAhSJWvVf

[BüttnerLab @ButtnerLab]

We are very proud to share our latest work describing the role of nuclear Hsp104 in protecting the translation machinery during quiescence
https://t.co/1KLxw96Ypr

[Beckmann Lab @BeckmannLab]

🎉We are thrilled to share our exciting new collaboration with @inada_lab and @jingdongcheng on how Otu2 recognizes and deubiquitinates 40S ribosomes after translation. Here is a thread with the most interesting findings:👇 #ribosome #ubiquitin #cryoEM

[Marcin J. Suskiewicz @MSuskiewicz]

We're happy to share a new paper (the 1st one!) from our SUMO project. A short summary follows. https://t.co/Te6d4buwIx

[Andreas Kohler @AKohler_Mito]

Publication alert 🚨In our manuscript, we provide robust methods to biochemically and structurally analyze #mitoribosomes: Yeast Mitoribosome Purification and Analyses by Sucrose Density Centrifugation and Immunoprecipitation https://t.co/Dz7c5iPuRQ @Ott_MitoLab #Mitochondria

[Johannes Herrmann @Herrmann_lab]

The TIM23 translocase of the inner membrane of mitochondria stabilizes PINK1 and thereby directly influences the distribution of Parkin. Beautiful mechanistic @CellReports study by Toshihiko Oka and Toshiya Endo relevant for mitophagy and parkinson. https://t.co/doKeqEKAz8

[AndréassonLab @AndreassonLab]

Genetic inactivation of essential HSF1 reveals an isolated transcriptional stress response selectively induced by protein misfolding | bioRxiv https://t.co/vJ3Xfdmi1m

[Verena Kohler @_VerenaKohler]

Check out this week's selection of publications on #MembraneContactSites!

https://t.co/SOCYXNjjnV

My favourite:
https://t.co/EEiFyQJDxS

Thanks to @Bims_BiomedNews for the pre-selection!

#ParkinsonsDisease #Neurodegeneration #MCS #Mitochondria #QualityControl #ESCRT

[EmSontagMU @EmSontagMU]

IT'S FINALLY HERE! A story years in the making about how cells handle misfolded proteins in the nucleus and cytoplasm 1/12
#proteostasis #proteinfolding https://t.co/2F6cRe7Yti

[AndréassonLab @AndreassonLab]

Chaperone-directed ribosome repair after oxidative damage: Molecular Cell https://t.co/lMByMacm3L

[Samrat Mukhopadhyay @SamratLabMohali]

Back-to-back JBC papers! Happy to share another JBC paper @jbiolchem on the phase separation of bacterial nucleoid-associated proteins. A great collaboration with my departmental colleague, P. Guptasarma @guptasarma_p & his lab @pglab_iiserm @DBS_IISERM

https://t.co/txxzweJlpj

[Verena Kohler @_VerenaKohler]

The proteomic landscape of genome-wide genetic perturbations https://t.co/rBLh87lWmW

[Verena Kohler @_VerenaKohler]

The phosphorylation status of Hsp82 regulates mitochondrial homeostasis during glucose sensing in Saccharomyces cerevisiae
#Proteostasis https://t.co/YAbCTOu0Kz