Arvind Gupta

Virology, Synthetic Biology, and Structural Biology @Kemijski Inštitut, Ljubljana

[Govind Gond @GSN923]

Think twice before buying during #FreedomSale.

My TV issue from the last sale is still unresolved after more than two weeks. Two replacement attempts failed because of Flipkart’s internal serial number mismatch, and now even the refund/replacement keeps getting delayed while my EMI has already started.

Existing customers should not be ignored while new sales are being promoted.

@Flipkart @FlipkartSupport @LGIndia

#ConsumerRights #CustomerExperience #RefundDelay #ReplacementDelay

[Alex Rives @alexrives]

Today we're announcing ESMFold2, an open scientific engine to power prediction, design, and discovery across protein biology.

The new model delivers state of the art performance on protein interactions, especially antibodies, a critical modality for therapeutics.

We have designed and validated miniprotein binders and single chain antibodies across five therapeutic targets that are important in cancer and immunology. We are seeing very high success rates, and affinities at levels consistent with therapeutic activity.

We’re also releasing an atlas of 6.8 billion proteins, and 1.1 billion predicted structures.

ESMFold2 is built on a state of the art language model that has been trained on billions of protein sequences.

A world model of protein biology emerges through language modeling.

We’ve used the techniques of mechanistic interpretability developed to understand large language models to understand the concepts ESM uses to represent proteins.

The model’s representation space has a compositional organization of features across scales, levels of complexity, and abstraction, that reflects and mirrors the understanding of protein biology developed through a century of empirical science.

This understanding emerges without prior knowledge, just from language modeling of protein sequences.

Language models are becoming a powerful substrate to understand and program biology.

The design of protein interactions is one of the most fundamental problems in biophysics, and has critical implications for the discovery of new medicines. A simple gradient based search with the model was able to discover high-affinity protein binders.

I'm excited by the potential this has to accelerate basic science and the understanding of proteins. And especially for the new avenues it opens up for therapeutic design and medicine.

[Roman Jerala @rjerala]

We're hiring @kemijski !
We aim to translate technologies of synthetic biology toward therapeutic applications, using both protein and RNA-based strategies. PhDs or MSc excited about #syntheticbiology #biotech #proteindesign #RNAdesign are invited to inquire and apply.
Pls RT🔁

[bioRxiv Synthetic Biology @bioRxiv_synbio]

CF2H: a Cell-Free Two-Hybrid platform for rapid protein binder screening https://t.co/FswM26Vs7M #biorxiv_synbio

[Arvind Gupta @Arvind_IISc]

@TadejSatler Congratulations

[Arvind Gupta @Arvind_IISc]

@Saurabh41288505 Congratulations @Saurabh41288505

[Arvind Gupta @Arvind_IISc]

@BICS_IISc @keshu_VRimmCh @iiscbangalore Congratulations...💥

[Molecular Biophysics Unit, IISc @MBU_IISc]

Please send your abstracts and register for our MBU@50 Golden Jubilee celebrations quickly! Check out the speakers below.
Poster abstract deadline: 23rd December
Registration deadline: 27th December
#mbu50

[Arvind Gupta @Arvind_IISc]

@dattarohini Congratulations..

[Chris H. Hill @chillzaa]

There's still 10 days left to apply for a 3yr postdoc in my group 🥳 Molecular biology, biophysics and single-molecule imaging to study ribosomal frameshifting in RNA viruses🧬Great department, lovely city and lots of career support from me:
https://t.co/1hqdfquog6

@BPSIYork

[Arvind Gupta @Arvind_IISc]

@arshukla Great! btw, beutiful 2mFo-DFc map of Phenylalanine.

[Ramaswamy S @hurryram]

Faculty positions at Purdue Biological Sciences. Great place to work. I have been here more than 2 years and enjoyed it thoroughly. We are looking for the best people in any area of biology. #biology_jobs #AcademicJobs https://t.co/x1aIkvQNac

[Sergey Ovchinnikov @sokrypton]

Exciting work from the Koga Lab! Design of de novo proteins (not just sequence, but fold). See if you can pick out which one of these forms a knot! 😎

[Arvind Gupta @Arvind_IISc]

@nikydna Congratulations Nikhil...

[Arvind Gupta @Arvind_IISc]

@SinghMLab @Mbu_Iisc @iiscbangalore Congratulations...

[Arvind Gupta @Arvind_IISc]

@MakeRefund11 [phone]

[EMBL @embl]

Using EMBL Hamburg’s world-class structural biology infrastructure, researchers advance the folding of protein ‘origami’ designed in the lab.

In the future, they aim to tailor these proteins to make new materials and deliver drugs & vaccines.

https://t.co/SWBOcRMeM9

[Institute for Protein Design @UWproteindesign]

New in @NatureComms: "Improved protein structure refinement guided by #deeplearning based accuracy estimation" https://t.co/fcZ9pnwui7

[Marjetka Podobnik @MarjetaPodobnik]

❗️Open position in structural biology ⁦@kemijski⁩ ⁦@NanoSciNIC⁩ in #Ljubljana #Slovenia. Come and join us on the sunny side of the Alps ☀️ #cryoEM #greatscience More ⬇️ Please RT🙏

[Arvind Gupta @Arvind_IISc]

@PenmatsaLab @PujamajumderPhD Congratulations and best wishes to Puja.