ASAP Team Awatramani

Five teams from NW Uni, Chicago and University of California, San Diego come together with the common goal of tackling some fundamental questions in PD research

[John Lukens @LukensJohnR]

Molecularly defined and spatially resolved cell atlas of the whole mouse brain @Nature
https://t.co/g0kaaRUn2E

[BryanRoth @zenbrainest]

Nice correspondence 5-HT2A protein (L) and 5-HT2A mRNA (R; MERFISH)
#psychedelics
https://t.co/mhopCkWrEB

[BevanLab @lab_bevan]

Increases in subthalamic activity facilitate locomotion and are selectively impaired in Huntington's disease mice with locomotor deficits, led by Dr. Josh Callahan.

https://t.co/5aO3ckDmqR

[MackenzieLab-Sweden @MackenzieLab1]

Proudly sharing our study on the subthalamic and para-subthalamic nuclei (STN vs. pSTN), and their different roles in behavioral avoidance and aversion. Great work by GP Serra et al: A role for the subthalamic nucleus in aversive learning: Cell Reports https://t.co/nZ3xA6ePOo

[ASAP Team Awatramani @AsapAwatramani]

Dopamine And Parkinson’s: Challenging Over 100 Years Of Research https://t.co/uAUiSKOIr5

[Michael Okun @MichaelOkun]

A person with Parkinson's disease can't walk because of severe freezing but put him on a bike and he is fine. Great case by Snijders and @basbloem Love the explanation: 'This striking kinesia paradoxica may be explained by the bicycle's rotating pedals, which may act as an external pacing cue. Alternatively, the motor-control mechanisms involved in gait as compared with other activities engaging the legs, such as cycling, could be affected differentially in Parkinson's disease. Cycling may offer a useful approach for exercise training in patients with Parkinson's who are “grounded” by severe freezing of gait.' https://t.co/fq5oe2oodu https://t.co/fq3jiDgUBC

[ASAP Team Awatramani @AsapAwatramani]

@ASAP_Research @Z_Gaertner Great work Maite and Zack.

[Aligning Science Across Parkinson’s @ASAP_Research]

Congrats to September's #OpenScience champions Maite Azorra and @Z_Gaertner! We're recognizing them for sharing underlying fiber photometry and RNA sequencing data, along with the analysis code, protocols, and RRIDs. See more: https://t.co/lt6XuE6j30

[Aligning Science Across Parkinson’s @ASAP_Research]

Congratulations to Ellen, Andy @SingletonNeuro, and Thomas @ThomasGasser23, for your outstanding contributions to the field 🥳. We're thrilled to have them as members of the ASAP network!

[Aligning Science Across Parkinson’s @ASAP_Research]

ICYMI: Did you catch ASAP's Managing Director, Ekemini Riley's interview on @NewsHour? Listen to her discuss GP2's historic GBA1 discovery.

[michaeljfox.org @MichaelJFoxOrg]

Until recently, our understanding of Parkinson’s biology has been limited to mainly volunteers of European descent. In a groundbreaking research discovery, today new findings published in @TheLancetNeuro reveal a novel genetic variant that increases the risk of Parkinson's among people of African descent. This finding — enabled by support from the @ASAP_Research initiative and The Michael J. Fox Foundation — importantly provides a step toward therapeutic development and research that is reflective of the diverse biology and experiences of all individuals living with Parkinson's.

Learn more: https://t.co/WcYPln41LD

[Aligning Science Across Parkinson’s @ASAP_Research]

Big news from GP2! Through cross-cohort analysis, GP2 investigators discovered a novel variant in GBA1 gene associated with higher risk of #Parkinsons in people of African & African Admixed populations. https://t.co/v4bZ4eNxPt

[Zachary Gaertner @Z_Gaertner]

That feeling when the director of the #NIH retweets your thesis project 😎

P.S. to those in the comments asking "didn't we already know that?" -- feel free to read the study in @NatureNeuro to see for yourself what's so novel about our findings!

[ASAP Team Awatramani @AsapAwatramani]

Wow ! what an honor! I hope we can continue to describe the distinctive properties of DA subtypes, with consequence for understanding PD and other DA related diseases.

[ASAP Team Awatramani @AsapAwatramani]

Great effort by Maite Azcorra and Zack Gaertner at unraveling molecular and functional distinctions within substantia nigra populations.

https://t.co/gEK1MEV4L3

[Aligning Science Across Parkinson’s @ASAP_Research]

We are excited for members from all 35 CRN teams to meet in San Diego to share emerging #PD research findings and trends. Stay tuned for post-meeting highlights!

[ASAP Team Awatramani @AsapAwatramani]

Yesterday Dr. Thomas Wichmann talked about "Non-Dopaminergic Neuroplasticity in Parkinsonism" in NW uni, Chicago and interacted with graduate students, post-docs thereafter. We @AsapAwatramani, Team Surmeier, lab @TaliaLerner (team Edwards) learnt a lot @ASAP_Research

[Loukia Parisiadou @parisiadoulab1]

The inspirational documentary “Still” about Michael J. Fox opened the Doc10 Film Festival in Chicago. Highlight the Q&A session with director Davis Guggenheim. Strong representation of @AsapAwatramani team members.