BABS Bioinformatics @TheCrick

News and comment from the core bioinformatics & biostatistics team analysing data for scientists at The Francis Crick Institute

[BABS Bioinformatics @TheCrick @BABSBioinformat]

We are hiring! We have a fantastic opportunity for a motivated bioinformatician to work at @TheCrick on a large multi-omic single-cell project in immuno-oncology.

please RT 🙂

@BABSBioinformat #multiomics #singlecell #immunoOncology https://t.co/p3pPpPwN0e

[BABS Bioinformatics @TheCrick @BABSBioinformat]

We are hiring. We are looking for a senior bioinformatics analyst to join us to work on amazing data rich projects in collaboration with @TheCrick scientists. Apply today #Bioinformatics
#sciencejobs
https://t.co/BgV4USkNOg

[BABS Bioinformatics @TheCrick @BABSBioinformat]

Fascinating work on spatial bias in metastatic subclone selection by @kevlitchfield, @TurajlicLab, @SwantonLab and Paul Bates's group. Stuart Horswell providing the bioinformatics. Nice to see our long-term collaboration with these groups continues to be fruitful. Congrats all.

[The Francis Crick Institute @TheCrick]

📰 A multidisciplinary team of researchers led by @kevlitchfield at @uclcancer and @TurajlicLab, @SwantonLab and Paul Bates at the Crick has found that the cancer cells in the centre of tumours have the highest chance of spreading around the body. https://t.co/FRL7LG8ZO8

[BABS Bioinformatics @TheCrick @BABSBioinformat]

More great @nf_core work here from our own @aka_hpatel. This time a new release of nf-core/rnaseq v3.1. The pipelines just keep coming. Congrats to Harshil, all involved and the wider nf-core community for crafting these incredibly useful pipelines.

[nf-core @nf_core]

Pipeline release! nf-core/rnaseq v3.1 (RNA sequencing analysis pipeline using STAR, RSEM, HISAT2 or Salmon with gene/isoform counts and extensive quality control.)

See the changelog: https://t.co/t1lSz9KejK

[Harshil Patel @aka_hpatel]

I would like to present our updated pipeline for de novo assembly and intra-host/low-frequency variant calling for viral samples from metagenomics or amplicon-based preps. This has been quite a while coming now but hopefully it was worth the wait! A 🧵👇

[BABS Bioinformatics @TheCrick @BABSBioinformat]

Important work here showing the effectiveness of #SARSCoV2 PCR testing in asymptomatic patients over time from @AdamJKucharski and others with statistical input from our own @gavinpaulkelly. Congratulations to all involved #CovidTesting

[Adam Kucharski @adamjkucharski]

How does PCR detectability vary over time since infection, and what are the implications for routine testing? Analysis with @HellewellJoel @timwrussell @bealelab @SAFERuclh and others now peer-reviewed and published: https://t.co/KR4vvgZ9y9

[BABS Bioinformatics @TheCrick @BABSBioinformat]

Great human spinal cord development work here with comparisons to mouse from @t_rayon and the @briscoejames lab. #scrnaseq analysis and neat visualisation by our own Chris Barrington #Bioinformatics

[Vicki Metzis @metzisv]

New #preprint and open resource on the developing human spinal cord: conservation and contrast between mouse and human @t_rayon @briscoejames

Want to check your predictions directly? Checkout Chris’ handy work @BABSBioinformat

https://t.co/QiQ71pttMN
https://t.co/GSJ1fkes0u

[Jérôme Nicod @Jerome_Nicod]

We are looking for 2 senior scientists to join the Sequencing Facility @TheCrick:
- Single Cell Scientist to expand our capacity and develop new applications https://t.co/Enx8E0SWD3
- Joint appointment with @LabGandhi to support @ASAP_Research project https://t.co/cR3IgooVz0

[BABS Bioinformatics @TheCrick @BABSBioinformat]

Second paper of the day for @BABSBioinformat Congratulations to @KasperFugger, the West lab @TheCrick, our own @aka_hpatel for providing the #CRISPR analysis and #Bioinformatics and all else involved.

[Kasper Fugger @KasperFugger]

Very excited to see our paper out in @ScienceMagazine describing the sensitisation of #BRCA cancer cells to #PARPinhibitors by targeting the ‘nucleotide sanitiser’ DNPH1. Massive thanks @SantosMariana_ @GraemeHewitt2 @BoultonLab @aka_hpatel @CarellThomas
https://t.co/MShj0LvGOg

[Harshil Patel @aka_hpatel]

Was an absolute pleasure collaborating on the #bioinformatics for this paper with @KasperFugger. Whole genome CRISPR screens are incredibly revealing when performed well! Congrats to all involved 🥳🤩😎✂️🧬

[BABS Bioinformatics @TheCrick @BABSBioinformat]

Great work here by the @ScaffidiLab with #CRISPR screen analysis and #Bioinformatics by our own @aka_hpatel Congratulations to all involved.

[The Scaffidi Lab @ScaffidiLab]

From dosage compensation in flies to cancer-specific vulnerability in humans - via replication stress. Nature is full of surprises.@TheCrick @MonserratJosep @NatureCellBio @aka_hpatel @DalalLabNCI @louise_richie https://t.co/D8FSrCoJZs

[BABS Bioinformatics @TheCrick @BABSBioinformat]

Oncogenic RAS transcriptional activity predicts outcome and response to chemotherapy in lung adenocarcinoma is the latest from a collaboration with the #downwardlab and our own @philipeast and @gavinpaulkelly with a nice thread from @sdecarne #KRAS #lungcancer #bioinformatics

[Sophie de Carné @sdecarne]

Excited to share our preprint on #KRAS in #lungcancer. With @phileast, we show that oncogenic RAS transcriptional activity predicts outcome and response to chemotherapy in lung adenocarcinoma whereas KRAS mutational status does not!
Please share 🙂
https://t.co/JpMMzZMf2p

[BABS Bioinformatics @TheCrick @BABSBioinformat]

Great work here from the @tatelab on targeting MYC deregulation in cancer. Bioinformatics support provided by our own Miriam Llorian-Sopena and Probir Chakravarty. Congratulations to all involved.

[Ed Tate @TateScience]

A new approach to target MYC deregulation in cancer -synthetic lethality with NMT inhibition! IMP1320 eliminates high-MYC tumours in 6 days @DinisCalado @sangerinstitute @TheCrick @impchemistry @imperialcollege @biorxivpreprint : https://t.co/sSdTjjGusq #oncology #drugdiscovery

[BABS Bioinformatics @TheCrick @BABSBioinformat]

Congratulations to the Behrens lab and now BABS' alumni Stuart Horswell for their latest showing proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12.

#bioinformaticsbybabs

https://t.co/Ey3ddWrnOM

[Kevin Litchfield @kevlitchfield]

Please check out and retweet this postdoc opportunity to work in an outstanding academic environment across UCL/Crick, and in a growing & fun lab! https://t.co/du3Y39SHb6

[Sophie de Carné @sdecarne]

Look #KRAS goes mainstream. There is even a quote from our very own Obi-Wan Kenobi ⁦@TheCrick⁩

The epic battle with cancer's 'Death Star' https://t.co/4lR7f8dDrF

[BABS Bioinformatics @TheCrick @BABSBioinformat]

Another paper here with input from BABS and another authorship this week for our own @gavinpaulkelly Congratulations to the @PataniLab, Gavin and all involved #astrocytes #Bioinformatics

[PataniLab @PataniLab]

Our latest in Nucleic Acids Research (@NAR_Open) reveals how astrocytes might become harmfully reactive through a post-transcriptional mechanism: https://t.co/SQLecmLgXv
Well done @ojziff @DoaaMTaha2 and Hamish Crerar @PataniLab @UCLIoN @TheCrick @mndresearch #DrivingMNDresearch

[Charlotte Capitanchik 🌙 @tiny_captain]

After a long & fruitful collab w/ the Kiyoshi Nagai lab @MRC_LMB we bring you psiCLIP - a method for profiling helicase-RNA contacts in defined spliceosome states. Led by Lisa Strittmatter & me @ule_lab @TheCrick, w/ fantastic insights from @Seb_Fica 1/7 https://t.co/dsMmAqA38U

[The Francis Crick Institute @TheCrick]

📰 New research in @FrontImmunol from our Tuberculosis Lab, @BABSBioinformat and @UCT_news shows why antiretroviral treatments for HIV also reduce the risk of people developing an active and dangerous Tuberculosis infection. https://t.co/5IIEc66tKg

[BABS Bioinformatics @TheCrick @BABSBioinformat]

The fruits of a successful collaboration with the Tuberculosis Lab @TheCrick with our own Deborah Schneider-Luftman, Chris Barrington and @gavinpaulkelly involved. Congratulations to the Wilkinson Lab and all involved #bioinformatics #tuberculosis #HIV

https://t.co/fEJOE2B50P