Jeremy Baskin

Click chemist, cell biologist, #chembio & #lipidtime enthusiast, occasional classical pianist (he/him). Also @[email protected]

[Jeremy Baskin @basktastic]

Thrilled to share this #lipidtime story in @JCellBiol where, led by Shiying Huang and in collaboration with Tamas Balla’s lab, we uncover plasticity in phospholipid metabolism to preserve plasma membrane identity and integrity in the face of disease-relevant perturbations!

[Journal of Cell Biology @JCellBiol]

How does the plasma #membrane preserve its #lipid identity under stress? The Baskin and Balla labs report a homeostatic circuit linking PI4P, phosphatidylserine, RhoB, and phospholipase D-driven phosphatidic acid. https://t.co/mTsss8ZZcX

@basktastic @weillinstitute @CornellChem

[CornellChemistry @CornellChem]

The National Institute of General Medical Sciences, part of the NIH, has awarded Cornell University a $2.5 million, five-year renewal of its Chemistry–Biology Interface (CBI) Predoctoral Training Program.
https://t.co/OPMqWsqWBV

[Ran Blekhman @blekhman]

Huge faculty recruitment effort at the University of Chicago -- a division-wide, open-rank search looking to hire about 20 faculty across 5 research areas in biology. Come be our colleague!

Full announcement: https://t.co/FoVLJpHqNS

[Jeremy Baskin @basktastic]

Delighted to share that Cornell's Chemistry–Biology Interface NIGMS Training Program has been renewed for another 5 years, to support interdisciplinary Ph.D. training across chemistry, biology & engineering! #chembio @CornellChem https://t.co/6d75qwlqhi

[Jeremy Baskin @basktastic]

Thrilled to share our new work, co-developed w/Adrian Salic's lab: #bioorthogonal probes for PE, a multifunctional membrane lipid and source of several protein modifications. Congrats to @YuanTingCho1, @BrittMW08 , Jade Xia & Cindy Jao! https://t.co/LIWXtKDePz #lipidtime

[Fikadu G. Tafesse @TheTafesseLab]

To help, we created the Lipid Interactome Repository, an open-access platform that centralizes and standardizes proteomics data on lipid–protein interactions.

https://t.co/tKAGVZGYGy

[Fikadu G. Tafesse @TheTafesseLab]

To understand what a lipid does, we need to know its partners.

Which proteins bind lipids and how can we capture those interactions?

Our new Nature Protocols paper provides a practical, step-by-step guide to identifying lipid-binding proteins. 🧵

[Abdou Rachid Thiam @Rachid_Thiam]

A long-standing mystery in cholesterol biology: why is ER cholesterol sensing so switch-like rather than gradual? Our answer: cholesteryl ester phase separation in the ER, which converts small lipid changes into a cooperative transcriptional response.

https://t.co/8npJgllxNx

[Nature Chemical Biology @nchembio]

Our August issue is live and is a Focus on computational work guiding biological discovery!

https://t.co/hD9rjhzdCm

The cover image depicts a computational-experimental approach to distinguish lipid solvation vs. lipid-ligand binding in membrane protein function

[Nature Chemical Biology @nchembio]

Small molecules can covalently modify proteins and generate covalent neoantigens, triggering immune responses. Now, a chemoproteomic platform enables the discovery of covalent neoantigens, which can also be harnessed for immunotherapeutic applications

https://t.co/6ebbp7YycW

[David R. Liu @davidrliu]

Today in @Nature we report how AI-guided redesign enhances protein evolution. Integrating ProteinMPNN sequence design with autonomous laboratory evolution, we establish a workflow to engineer enzymes with improved properties over those evolved from natural proteins. Redesigned starting points consistently evolve an expanded fitness landscape, reaching new function with higher activity, specificity, and stability than their natural counterparts.
https://t.co/pNlw6z1zvU
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[James Olzmann @OlzmannLab]

New preprint! We find that fatty acid double-bond geometry alters their metabolic fate and ferroptosis sensitivity. Trans fatty acids are metabolized differently from their cis counterparts, reshaping membrane phospholipids and ferroptosis sensitivity.
https://t.co/XaaAGyDh6J

[Josh Baccile @joshbaccile]

Metabolic Labeling and Visualization of Isoprenoids Using Alkyne‐Modified DMAPP Analogs in Bacillus subtilis - Hulsey - Angewandte Chemie International Edition - Wiley Online Library https://t.co/Mqh3VHmyeA

[jared toettcher @toettch]

Hey friends, we're hiring over here at Princeton BioE! In addition to the usual positions (faculty, grad students, postdocs), BioE is looking for a Program Manager to oversee big multi-PI projects (e.g. DARPA, ARPA-H). Pass along & apply if interested! https://t.co/6aoz23961c

[Jeremy Baskin @basktastic]

The last leg of my trip to Japan was at the 55th Naito Conference on Chemical Biology: inspiring science in beautiful Hokkaido at the incomparable Chateraisé Gateaux Kingdom — a 3-in-1 hotel, spa, and sweets factory. I’ve been surrounded by so many delicious lipids all week! 🤤

[Jeremy Baskin @basktastic]

Excited and grateful to have been promoted to Professor. Many thanks to the outstanding students and postdocs in my lab and to my colleagues at Cornell and across the #chembio and #lipidtime communities for your continued support!

[Jeremy Baskin @basktastic]

@RyosukeKojima4 @UTokyo_News @MizLabUT I enjoyed our discussion immensely, Ryosuke, and I hope that you feel better soon!

[Jeremy Baskin @basktastic]

Fantastic #lipidtime conversations yesterday at @UTokyo_News — thank you to @MizLabUT for hosting my visit!

[Jeeyun Chung @JeeyunC]

What do lipid droplets do in neurons? Thrilled to share the 🌟1st preprint from my lab, led by Eleni Katafygiotou, showing activity-dependent formation of neuronal LDs in vitro and in vivo, and the impact of LD modulation on neuronal function and behavior.
https://t.co/7V9gwR0vLH

[Sarafan ChEM-H @Stanford_ChEMH]

Today’s impressive lineup of speakers include former awardees of The Ono Initiative Jonathan Long @longlabstanford, Yamuna Krishnan @UChiChemistry, Xiaoyu Zhang @NorthwesternU, @fordycelab, @basktastic, @StacyMalaker, and @angadmehta as well as keynote speaker @ChemicalBiology!