Islet Biology Laboratory

Cellular and molecular biologists, physiologists and pharmacists work together to safe the beta-cell in diabetes

[Islet Biology Laboratory @BiologyIslet]

When sugar 🍬takes your breath🫁 away: how diabetes accelerates COPD progression. Check our article summary @embojournal
https://t.co/N3WwDZdriZ

[Islet Biology Laboratory @BiologyIslet]

Uni Bremen 🇩🇪is hiring a new full professor👩🏾‍🔬👨‍🔬 in Cell Biology 🧫with expertise in mitochondrial heterogeneity @mitojobs and high resolution imaging🔍@AcademiaNet_org @LevWopo
https://t.co/jtMUCkDbhZ

[Islet Biology Laboratory @BiologyIslet]

Trigger for Type 1 diabetes- starting in the whole pancreas: inflammation and viral infection upregulate YAP. Links pancreatitis and T1D-exocrine-islet-immune interactions are key for T1D therapy
https://t.co/tpZwKdJm84
@BiologyIslet
@BreakthroughT1D
@NatureComms
@dfg_public

[Islet Biology Laboratory @BiologyIslet]

@BGauthierLab @cobo_nadia @BreakthroughT1D @diabetescero @LifeLength @HUVMacarena @BiobancoDelSSPA @cabimer @FpSalud @AndaluciaJunta Congrats. Well deserved. For a world with Type NONE Diabetes

[Matthias Tschöp @MatthiasTschop]

Her work paved the way for blockbuster obesity drugs. Now, she’s fighting for recognition | Science | AAAS https://t.co/c8tVHCRwWc

[Islet Biology Laboratory @BiologyIslet]

Postdoctoral Positions for female scientists @mitojobs in an interdisciplinary project of Molecular Genetics Lab and @BiologyIslet @UniBremen @LevWopo @AcademiaNet_org to identify principal physiology of mitochondrial networks and diversity https://t.co/gEZ4SCiUZJ

[The Obfuscated Dreams of Scheherazade @ringringrussia]

Nice! A local Bavarian newspaper called @SZ wrote about us: https://t.co/TkRBOInuOb

[Maike Sander & Lab @msanderlab]

With several ongoing clinical trials, beta cell replacement is becoming a real possibility. I look forward to this workshop!

[Islet Biology Laboratory @BiologyIslet]

@KlausKaestner Awesome scRNA analysis & tool! Found our favorite genes #T1D

[Islet Biology Laboratory @BiologyIslet]

Give Ukrainians a home https://t.co/yLNQr7uLeb

[Islet Biology Laboratory @BiologyIslet]

https://t.co/mF2OAn7auB
The Sun lab has identified how beta-cells can smell the small insulin fragment insB9-23, associated with T1D. It binds to olfactory receptor Olfr109 to foster islet inflammation, beta-cell failure and diabetes progression.

[nPOD Diabetes @DiabetesnPOD]

Enjoying the beach and nice weather at #nPOD2022! Starting off Day 3 with an exciting seminar on Alpha Cells!

[Islet Biology Laboratory @BiologyIslet]

The Hippo pathway is a key player in diabetes and metabolism regulation.
Another confirmation how robustly deletion of the Hippo kinase MST1 protects the beta-cell and prevents diabetes:
https://t.co/PBNCh3rX5y

[Islet Biology Laboratory @BiologyIslet]

Important confirmation and add-on to our recent study-we could just show that the inhibition of PHLPP1 phosphatase also normalised glucose levels, insulin secretion and prevented diabetes in obese hyperglycemic db/db mice:
https://t.co/XL1e79qxm8

[Islet Biology Laboratory @BiologyIslet]

@DanielJDrucker Great point! Authors correctly question this themselves: “Whether dapagliflozin truly prevents diabetes or only masks early diabetes …”. Another idea for pre-diabetes: reduce calories🥗 exercise 🏃‍♀️and (or😕) take metformin 💊

[Daniel J Drucker @DanielJDrucker]

Studies of pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 (PHLPP1/2) reveals their upregulation leads to β-cell failure, positioning them as "as targets for functional regenerative therapy of pancreatic β cells #diabetes " https://t.co/3XfvrdbKe1

[Dr. Jessica Dunne @jessdunnephd]

Great last morning run with @jamielfelton @professormcraig @LinnemannLab, Kathrin Maedler and John Kaddis at #nPOD2020. Looking forward to seeing more of you next year on the beach in Jacksonville!

[Dr. Jessica Dunne @jessdunnephd]

Nice review from Kathrin Maedler’s group bringing together more recent evidence to suggest a viral trigger in #T1D.

[Bruce Verchere @BruceVerchere]

Really @WHO?
You can do better than this.

[Journal of Cell Biology @JCellBiol]

Maedler and Ardestani discuss recent work from Chau et al. on the role of mTOR for β cell survival in diabetes https://t.co/3zIXFNUpzg