Brian Brain

Retweeting interesting stuff on cognitive and clinical neurosciences. British.

[Amir Lawen @AmirLawen]

Dopamine shifts from reward to cue during learning. But how is this reflected across the brain?

Combining NAc dopamine photometry with whole-brain fMRI in behaving mice, we link this classic dopamine dynamic to brain-wide changes as learning unfolds.

https://t.co/VFcRNleeuR

[Abhimanyu Mahajan @AMahajanMD]

Does physical activity modulate cognitive and motor progression in PD?

Analysis of longitudinal, observational data from @ccbpstudy demonstrated that higher levels of physical activity associated with slower cognitive decline and motor progression.

Link: https://t.co/AofcA4rJ8i

[Ankit Jha @ankit_jha_rs]

Excited to share our paper on sex-differences in resting state DLPFC examining motion correction approaches and depression-anxiety comorbidity. Thankful for the incredible support from my supervisor @VSPsych 🙏🏻. 🧵https://t.co/ywAK6FY4nU

[Dr. Millie Rincón-Cortés 🇵🇷 @houseofmind]

Excited to share the lab's first fiber photometry paper, out now in #JNeurosci 🎉😃🐀🧠💫
This one feels particularly special: it marks a new experimental direction for the lab and reflects so much hard work, troubleshooting, learning, and persistence from an incredible team 🔬✨

[Tristan T. Herring @tristantherring]

New (open access) commentary is out now. We review research on symptom validity tests and outline challenges and future directions for the field.

https://t.co/2cMvwhhBkq

[Franco Izzo @FrancoIzzo85]

Happy to announce our latest review is out @NatureRevCancer ! We provide an overview of the latests advances and future directions in genotype-aware single cell multiomic methods, for linking genotypes to phenotypes in single cells:
https://t.co/cB9D3OOJJx

[Varsha Singh @VsPsych]

New publication🎉✨Took years, excited to share we looked at how physical-mental health are linked & how they help understand sex-specific pattern of maladjustment in adolescence. An exhausting but enriching experience, enabled by team efforts ✨☀️🙏🏻. https://t.co/TlcbQssi1V

[Gene Yeo’s Lab at UC San Diego @yeo_lab]

Our new paper: we found that in in vitro stem cell models, ARID5A, an RNA-binding protein in brain immune cells (microglia), links immune signaling, waste clearance, and iron metabolism — and controlling it may protect neurons in neurodegeneration. https://t.co/xIWeLC4f8g

[Graham Pluck @DrGPluck]

The risk of refractory status epilepticus can be reduced. We demonstrate some of the associated factors in this new study; factors such as speed of benzodiazepine administration. Published in @EpilepsyBehavi1
https://t.co/tp9HHXzg7g

[Joel W. Blanchard, PhD @JoelWBlanchard]

We’re finally able to see tau at the single-molecule level and more deeply explore neurodegenerative drivers.

Thanks for the collaboration, @NautilusBio! There is real patient impact potential in this work.

Read the paper here: https://t.co/3yXl7NkfRY

[Joon An @joonomics]

Can a virtual cell tell us where to look for autism genes?
In our new preprint, NOCAP-AI, we trained a single-cell foundation model on 3.6 million cells from human brain organoids to learn how genetic perturbations affect developing brain cells.

[Jim Heys @jamesgheys1]

I’m very excited to share our new paper, led by the very talented Jack Bowler, a postdoc in the lab!

https://t.co/JCjF0EyUer

We all know that the way we learn something matters. But how does a training curriculum actually shape how the brain learns to solve a problem? a 🧵 1/N

[Mitchell Morningstar @neuromorning]

Large-Scale In Vivo Electrophysiology Analysis Reveals Opposing Thalamic and Hippocampal Excitability After Third-Trimester-Equivalent Alcohol Exposure in Mice | Journal of Neurophysiology | American Physiological Society https://t.co/5v3txiUx7S

[Yin Shen @YinShenLab]

I’m delighted to share our latest work on the 3D epigenome of glial cell types in the developing human cortex, published today in Nature!
https://t.co/wB1JDj0F2Z

[Agustin Ibañez @AgustinMIbanez]

In two accompanying studies, we found converging evidence that eye–brain dynamics may offer a low-cost window into Alzheimer’s biology and its potential for stage-specific neuroplasticity. Oculomotor signatures differentiate AT(N) profiles, while oculomotor training shows distinct cognitive, tau, and physiological responses across MCI stages. Congrats Ricardo Martínez-Flores, Hans Supèr & the entire team:
https://t.co/iorvRa4KRu & https://t.co/00k5jQFpZf @GeroScienceAGE

[Xiaoyu Xu @chocoxu0925]

Excited to share our latest @natBME paper!🥳How does structural connectivity (SC) in ADHD deviate from typical development? We show delayed maturation of association-network SC, with some deviations declining with age, tracking symptoms, and predicting treatment response.

[Raffaele Mazziotti @raffamazziotti]

Our MEYELens paper is out in Behavior Research Methods!

Affordable, open-source and fully 3D-printable platform for #EyeTracking & #Pupillometry.

📄 https://t.co/1tQ695gLZb
🔧 https://t.co/EyTHhHZ6C7
@giacomovec @AleBenedetto89 @tpizzorusso @B0312Laura @Psychonomic_Soc

[Lauri Nummenmaa @LNummenmaa]

Are the descriptions of emotions in natural language consistent with bodily feelings that people experience during emotions? Our new @TurkuPETCentre study based on >500 million words of text confirms that yes they are, and consistently across languages 👇!

[jcarriot @jcarriot]

The brain may not encode natural movement the way laboratory studies led us to think.
We found that cortical neurons use distributed bursts to efficiently represent features of everyday self-motion.
New paper @ScienceAdvances:
https://t.co/FWzPokMYHE

#Neuroscience #vestibular

[Kanaka Rajan @KanakaRajanPhD]

Our approach for untangling brain-wide interactions is out today in @NeuroCellPress!

Massive congrats to @mattperich for leading this incredible effort since 2020, and a huge thank you to all of our collaborators.

https://t.co/aIjzMDpQnE