Rodrigo Arcoverde Cerveira

Now on bluesky: @cerveirarodrigo.bsky.social

Bioinformatics, vaccinology, immunology, science, art and cheese.

PhD student in Karolinska Institutet, Sweden

[Rodrigo Arcoverde Cerveira @CerveiraRodrigo]

Thanks to all the co-authors! Without your feedback, data, and advice, scifer would not exist.
@sebbeols @marcelm_ @KlaraLenart @FreddieHellgren @TKreslavsky

[Rodrigo Arcoverde Cerveira @CerveiraRodrigo]

It's finally out as a paper :D

🧵1/ Introducing scifer, our R/Bioconductor package developed with B cell receptor (BCR) sequences in mind, but adaptable to other sequence types. Pre-trained on real datasets, scifer is designed to streamline index cell sorting sequencing workflow

[ImmunoInformatics @immuno_inform]

A new research article was published in ImmunoInformatics
👇
Scifer: an R/Bioconductor package for large-scale integration of Sanger sequencing and flow cytometry data of index-sorted single cells https://t.co/Udc3AeaJB9

[Rodrigo Arcoverde Cerveira @CerveiraRodrigo]

4/ Highly customizable and open-source, scifer is available on Bioconductor and GitHub. Fine-tune it for new applications, leverage parallel processing, and enjoy efficient, streamlined workflows. Contributions are welcome on GitHub issues! #OpenScience #Bioinformatics

[Paul Novosad @paulnovosad]

What kind of childhood makes a top scientist? Is it enough to have all the right traits (brilliance, grit, etc) or do you need the right family too?

And why should we care? A 🧵 on our paper on the Nobel Laureates.

A teaser: the income distribution of the laureates' fathers.1/N

[JCI insight @JCI_insight]

Modulation of innate immune response to mRNA vaccination after SARS-CoV-2 infection or sequential vaccination in humans: https://t.co/cm3pjY8xzk

@karolinskainst
#Immunology #Vaccines

[Prof. Stefan Rahmstorf 🌏 🦣 @rahmstorf]

The chart shows the planetary boundaries. 6 of 9 have already been transgressed. Humanity has left the safe space (green) and entered high risk territory. https://t.co/nrXcHxIp9g

[NEJM @NEJM]

Dengue outbreaks can affect 390 million persons yearly. In a trial involving 16,235 persons in Brazil, the live, attenuated, tetravalent Butantan vaccine was efficacious in all age groups at 2 years. Read the full trial results: https://t.co/YY0iRP2Xqb

[Science Magazine @ScienceMagazine]

A dense system of pre-Hispanic urban centers, characterized by constructed platforms and plazas and connected by large, straight roads, has been discovered in the upper Amazon.

Learn more in the latest issue of Science: https://t.co/TrQ3NDDLnc

[Human Immunome Project @ImmunomePro]

"The next moonshot in life sciences is decoding the human immune system."

Learn why modeling the immune system can transform global health, and how we plan to do it, in this must read from @janemetcalfe in @TheAtlantic: https://t.co/qwgrHY42VJ

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

[Rodrigo Arcoverde Cerveira @CerveiraRodrigo]

Glad I could contribute to these findings!

[Sebastian Ols @sebbeols]

Happy to share our latest publication @ImmunityCP: Multivalent antigen display on nanoparticle immunogens increases B cell clonotype diversity and neutralization breadth to pneumoviruses
https://t.co/vQteifxPcT

[Oxford Protein Informatics Group (OPIG) @OPIGlets]

Bora Guloglu's article on how VL domain identity can influence CDRH3 structure and dynamics has just been published in @FrontImmunol!

https://t.co/rBLr7WtFRT

[Nature Communications @NatureComms]

mRNA rabies vaccine induces durable immune response in macaques

@doc_brown79 @CerveiraRodrigo

#rabies #vaccines #immunology #virology

https://t.co/oeMZOGJNiq

[Rodrigo Arcoverde Cerveira @CerveiraRodrigo]

10/10 This was collaborative work with the help of many collaborators. Including @CureVacRNA, @Loeffler_News , @NillaKH. This study was conducted in Karin Loré group, at @karolinskainst , by Fredrika Hellgren, @doc_brown79 , and myself.

[Rodrigo Arcoverde Cerveira @CerveiraRodrigo]

1/10 Have you ever thought about comparing the immune response of a new mRNA vaccine platform with a traditional inactivated vaccine? We have done that for a #rabies vaccine and evaluated in detail its elicited immune responses.
https://t.co/5jsl92tcD6

[Rodrigo Arcoverde Cerveira @CerveiraRodrigo]

9/10 Finally, the polyclonal responses and high antibody titers were also translatable to higher cross-neutralization to other lyssaviruses.