Chase Feiger, M.D.

AI, Robotics, Life Sciences, Healthcare

[OpenEvidence @EvidenceOpen]

Rigorous evaluation of medical AI is good for everyone, and we welcome it. Counter to a half-dozen independent studies from institutions such as the Mayo Clinic that were highly positive on OpenEvidence—a lone paper now purports to show that generalized AI beats specialized clinical AI (@UpToDate, @EvidenceOpen). The paper has a massive undisclosed conflict of interest and irredeemable methodological flaws.

Behind the scenes: The study authors run a competing in-house medical AI at their hospital, and asked OpenEvidence for an API to power it — including rights to build a "competing product" with OpenEvidence's own API. OpenEvidence declined. Then, this paper coincidentally appeared.

Point-by-point, looking closely at the datasets used in the study, the disingenuous and fatal flaws become immediately apparent 🧵.

[Chase Feiger, M.D. @ChaseFeiger]

I never would have guessed that one of @ostrohealth early failures would end up memorialized in @Entrepreneur.

If you’d asked me in 2020, I would’ve assumed that story stayed buried in a notebook somewhere.

But here we are...

https://t.co/GdpwuQ7B6N

[Chase Feiger, M.D. @ChaseFeiger]

@ValerieAnne1970 @ValerieAnne1970 - I urge you to stop spreading misinformation about LDL-C and statins. What is more concerning is the number of educated, high health literate individuals who are watching this and believing it to be true. This demonstrates a much larger health literacy issue.

[David Sacks @DavidSacks]

As a response to socialism, Miami will replace NYC as the finance capital and Austin will replace SF as the tech capital.

[Joe Lonsdale @JTLonsdale]

Please do NOT come work for any company I have founded or am investing in if this LMT pro-mediocracy ad appeals to you.

We are deterring our adversaries to save millions of lives, and reshoring to build the next American century. Not whatever this is.

[Elon Musk @elonmusk]

Move to Austin! It gets better very year.

So many cool, world-class people are moving to Austin from SF, LA, NY, London and many other parts of the world!

Austin++

[Joe Lonsdale @JTLonsdale]

Flying home to Austin, TX.

American Renaissance city.

Great food & music; and lots of my favorite people live in town. Many are building stadiums, clubs or other fun places.

@uaustinorg, @Saronic, @neuralink, @basepowerco, @MeritFirstUS, and dozens of others bringing in stars.

[Joe Gebbia @jgebbia]

Moved to ATX five years ago and found boomtown energy with bright people. Only gotten better since. Long on Austin.

[Chase Feiger, M.D. @ChaseFeiger]

Game changer. Incredible work @OpenAI team! cc: @ChrisCamillo https://t.co/jjEsYOKSkU

[Chase Feiger, M.D. @ChaseFeiger]

@dottkhan good time! 🤣

[Imran Khan @dottkhan]

I learned a new financial metric tonight. It’s EBITDACC (Earnings before interest tax depreciation amortization and cost of compute). We are looking for EBITDACC positive companies. DM is open.

[Chase Feiger, M.D. @ChaseFeiger]

@dottkhan Yes!

[Patrick Collison @patrickc]

We have three cool announcements today:

(1) @OpenAI is launching commerce in ChatGPT. Their new Instant Checkout is powered by @stripe.
(2) We're releasing the Agentic Commerce Protocol, codeveloped by Stripe and OpenAI.
(3) @stripe is launching an API for agentic payments, called Shared Payment Tokens.

It's clear that internet purchasing modalities are going to change a lot, and we're excited to start to lay some of the foundations.

Links below!

[tobi lutke @tobi]

Shopify merchants will be able to sell directly in ChatGPT.

We’ve been working with @OpenAI for quite some time so people can search and buy products in chat, and it’s something we’ve had a hard time keeping quiet.

Rollout is coming very very soon.

[Satya Nadella @satyanadella]

It’s been a few weeks since we brought GPT-5 to Microsoft 365 Copilot, and it’s quickly become part of my everyday workflow, adding a new layer of intelligence spanning all my apps.

Here are 5 prompts that show what’s now possible:

[Sam Altman @sama]

i can't think of a non-cliche way to say this, but everyone who says having a kid is the best thing in the world is both correct and still somehow understating it.

[Chris Camillo @ChrisCamillo]

.@sama The world badly needs a Google Trends equivalent for AI queries. Marketers + investors, share + RT if you agree.

[Chase Feiger, M.D. @ChaseFeiger]

The correction will come.
The long-term value? Undeniable.

Thanks to @Fortune for including my perspective.

https://t.co/vchiGwa2Yp

[Chase Feiger, M.D. @ChaseFeiger]

@FortuneMagazine asked me about the so-called “AI bubble.”

My take: volatility is part of every major tech cycle, but in healthcare, AI’s impact is already tangible.

Cc: @ChrisCamillo @ostrohealth @AhmedElsayyad_

https://t.co/vchiGwa2Yp

[Chase Feiger, M.D. @ChaseFeiger]

But that doesn’t mean AI is overhyped. It means the winners will be the ones who prove AI can deliver durable outcomes in complex, regulated industries.