John Bennett

Colgate 2019
Stanford Chem 👨‍🔬🏳️‍🌈
Bogyo Lab
He/him

[preLights @preLights]

New #postLight uploaded by @goh_zhanghe 👀

He revisits work from @ChemBio_John & colleagues (from @mbogyo & @fidocklab) originally posted as a preprint and now published in @CellChemBiol

postLight = journey from #preprint to peer-reviewed paper.🛣️
https://t.co/FIRqRqyX1X

[Goh Zhang-He (he/him) (goh-zhanghe.bsky.social) @goh_zhanghe]

Congratulations on getting this published! I recall it was a pleasure to highlight this work (at @preLights) when it was still a preprint

[John Bennett @ChemBio_John]

Check it out here: https://t.co/zvgRHoGMnP

[John Bennett @ChemBio_John]

I'm excited to share our latest collaboration with @fidocklab using mixed alkyl/aryl phosphonates to identify possible drug targets in Plasmodium. Our work offers a possible method for deciphering important drug targets, mechanism of action, and mechanisms of resistance.

[Matthew Bogyo @mbogyo]

Our paper using mixed alkyl aryl phosphonates to identify serine hydrolases in Plasmodium falciparum that are potential drug targets is out. Great work from @ChemBio_John and collaborations with @fidocklab. Free Download here -https://t.co/b4SNq0PS9G

https://t.co/S6m7d0cInJ

[Matthew Bogyo @mbogyo]

Happy for these two guys who just graduated last week. They started in the lab 2 days apart and finished 1 day apart. Congrats to @FrancoFaucher and @ChemBio_John. On to many more great things as PhDs.

[preLights @preLights]

Lessons from nature for antimalarial agent discovery. 💊

@ChemBio_John & colleagues (from @mbogyo & @fidocklab) develop serine hydrolase inhibitors targeting plasmodium parasites.

Preprint highlighted by @goh_zhanghe. Includes an author response! 👀 ⬇️ https://t.co/FIRqRqypcp

[John Bennett @ChemBio_John]

This work once again shows the value of targeting serine hydrolases within the parasite with covalent molecules that prevent the rapid evolution of resistance. These types of strategies will be invaluable in the identification of novel mechanisms of action.

[John Bennett @ChemBio_John]

Check out our latest work on Plasmodium with @fidocklab where we explored a novel set of mixed alkyl/aryl phsophonates as tool compounds to identify and probe essential lipid metabolizing serine hydrolases and pathways within the parasite.

[Matthew Bogyo @mbogyo]

Our latest collaboration with @fidocklab is out. PhD student @ChemBio_John found mixed aryl/alkyl phosphonates that target essential serine hydrolases in Plasmodium falciparum. They kill parasites with low overall induced resistance. https://t.co/u35aqo43Qk

[Matthew Bogyo @mbogyo]

Our latest collaboration with @fidocklab is out. PhD student @ChemBio_John found mixed aryl/alkyl phosphonates that target essential serine hydrolases in Plasmodium falciparum. They kill parasites with low overall induced resistance. https://t.co/u35aqo43Qk

[Long Lab @longlabstanford]

Congratulations @AmandaWigg_, thesis work now in press @NatureComms. Inspired by the structure of the hypothalamic hormone TRH (pyroglu-his-pro-amide), Amanda shows “capping” defines a chemical motif present in many previously unknown bioactive peptides
https://t.co/x0MYExgURu

[Kurt Ward @micro_kiwi]

Really happy to have this work published. It's been great working with @mbogyo and @ChemBio_John on this project.

[John Bennett @ChemBio_John]

Check our most recent work highlighting the importance of covalency in overcoming resistance! Really proud to get this work out and thank you to all of our collaborators!

[Matthew Bogyo @mbogyo]

Check out our latest work targeting the malaria proteasome. Another outstanding collaboration with @fidocklab. Congrats to @ChemBio_John and the other authors! https://t.co/9kc0ZB6M8p

[Mekedlawit Setegne @MekedlawitTS]

HAYYYYY, joining the role call as a FIFTH year @StanfordUChem characterizing cholesterol protein interactome in bacterium that makes its own cholesterol 🤯🧫

A girl that wears many hats & interested in using chemical tools to probe molecular biology!

#BlackInChemRollCall

[John Bennett @ChemBio_John]

Check out our latest work on how we have used covalent macrocyclic inhibitors of the malaria proteasome to combat the growth of resistance. Big shout-out to @fidocklab @RyanKMuir and everyone else who was a part of this story!

[Matthew Bogyo @mbogyo]

It's all about covalent inhibitors! See how covalent macrocycles that target the malaria proteasome can prevent resistance. Great work from the Bogyo lab @ChemBio_John in collaboration with @fidocklab.

https://t.co/0SxP3D2NJu

[Amanda Wiggenhorn @AmandaWigg_]

Peptides with some extra flare – capped peptides! I am excited to share the preprint of my work on capped peptides. Capped peptides represent a large class of circulating molecules. (1/9) https://t.co/OWKTUtMtm7 @longlabstanford @Stanford_ChEMH @WuTsaiAlliance @StanfordPath

[Laura Keller @kellerlauraj]

So excited to finally be sharing this story!! Thank you to the many collaborators (including @taylorhnguyen in KC Huang's lab, the teams of @ajodonoghue, @MJNiphakis and Ami Bhatt, and my mentor @MLakeme) for helping me and @mbogyo bring this story to life!

[Matthew Bogyo @mbogyo]

Our first paper on our efforts mapping serine hydrolases in gut commensal bacteria is out. We identified a homolog of the human DPP4 protease in B. theta that is important for community fitness. https://t.co/24vXeHnAJ6

[Anthony Chianese @ARChianese]

Check out our latest work on ChemRxiv, where make our first entry into the catalytic hydrogenation of epoxides! This work was done by @ColgateChem students Fallyn Kirlin, Olivia Borden, @mchead12, and Sophie Kelly.

https://t.co/uCdGQm93oz

[Scott Lovell @scottlovell34]

I'm searching for a PhD student to start in my brand new lab @UniofBath in Oct 2022. The project will use phage display for covalent ligand discovery. Retweets are much appreciated. https://t.co/MYLrash30j