Anu Lala (Anuradha Lala-Trindade)

Mother/wife/daughter. 💜Function cardiologist. @JCardFail Co-EIC. HF Fellowship PD @MountSinaiNYC; #IntegrativeMedicine; in pursuit of more #SelfAwareness

[Anu Lala (Anuradha Lala-Trindade) @dranulala]

Dear #FunctionNotFailure community,

Thank you for the gift of being apart of this remarkable family. 💜 Onwards we go, focusing on community, science, impact, perseverance and innovation. 📈

@HFSA @robmentz @ShashankSinhaMD @DrMarthaGulati @j_alvarezgarcia @EMDeFilippisMD @SantosGallegoMD @AndrewJSauer @noshreza @JasonKatzMD @KSharmaMD @mpsotka @orlyvardeny @ngilotraMD @heartofthemater

[Journal of Cardiac Failure @JCardFail]

We are proud of the progress reflected in this year’s Impact Factor of 9.9, but even more proud of what all of this represents.

A heartfelt THANK YOU to our entire JCF Family. Your engagement as authors, reviewers, readers, and mentors continues to drive this collective success.

[Anu Lala (Anuradha Lala-Trindade) @dranulala]

I've been MIA on SoME fronts...taking some time to go inward & recalibrate.

Still, wanted to share our Aug Ed page @JCardFail on something I'm always working on...embracing uncertainty.

It may resonate w/our trainees waiting on interviews as well as graduating ones taking on new jobs.

Wishing everyone compassion and grace...as we all navigate the ongoing challenge of embracing uncertainty 🙏

https://t.co/lbxinhPBBI

[Gregg Fonarow MD @gcfmd]

📉 Treating high blood pressure is one of the best ways to prevent HF ❤️

✅ Standard control (<140): ~50% less HF

🚀 Intensive/SPRINT (<120): adds ~38% more

💥 Combined: ~69% ↓

🇺🇸 Nationwide, Rx and going intensive could prevent ~167,000 HF cases/year in eligible adults

[Pablo Corral MD @drpablocorral]

👉Just published in @NEJM: STAREE Trial

☝️At last, robust randomized evidence on statins for primary prevention in older adults.

🔹 9,971 adults ≥70 years, without cardiovascular disease, diabetes, or dementia
🔹 Atorvastatin 40 mg vs placebo
🔹 Median follow-up: 5.9 years
🔹 Baseline LDL-C: ~127 mg/dL NEJMoa2607314.pdf

👉Key findings:

🔹 30% reduction in major cardiovascular events
HR 0.70 (95% CI 0.61–0.82; P<0.001)
🔹 NNT = 37 over 5.9 years
🔹 MI: HR 0.57
🔹 Coronary revascularization: HR 0.57
🔹 Benefit was also observed in participants ≥75 years

👉Importantly:

🔹 No increase in dementia (HR 1.03)
🔹 No significant effect on all-cause mortality
🔹 No improvement in overall disability-free survival
🔹 Serious adverse events were similar between groups.

☝️Bottom line:
Age alone should not be a reason to withhold LDL-C lowering. Even in healthy adults ≥70 years, lowering LDL-C translates into substantial cardiovascular benefit.

@society_eas
@nationallipid

🔗https://t.co/RfJMrlWLaU

[Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 @DrMarthaGulati]

🫀 #REACT at #ESCCongress #Hotline

How early does atherosclerosis really begin?

16,808 adults, age 18–70 without known ASCVD underwent coronary, carotid & femoral imaging

🔎 Silent atherosclerosis: 57.1% overall
➡️ Already present in ~1 in 13 adults aged 18–29
➡️ ~9 in 10 by age 60–70!

💃🏻Women: steep rise during midlife, around menopausal transition; men developed atherosclerosis ~5–10 years earlier

🫀Atherosclerosis begins decades before clinical events—and often before conventional risk scores identify high risk. REACT should make us think about prevention much earlier

Next question: can imaging-guided early intervention actually prevent progression and events? Or should we just work to prevent CVD in everyone?

📄 @NEJM
https://t.co/rcQrmJz8Er

#ASCVD #Prevention #WomensHeartHealth #CVPrev

[Anu Lala (Anuradha Lala-Trindade) @dranulala]

@mchonig @DrMarthaGulati @pnatarajanmd Incredible!

[Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 @DrMarthaGulati]

This is simply outstanding! What wonderful mentors @mchonig @pnatarajanmd 👏🏽👏🏽👏🏽 to let a medical student present and she was outstanding!

[Eric Topol @EricTopol]

Of the major age-related diseases (cardiovascular, cancer, neurodegenerative) heart is the most preventable with lifestyle factors and medications.
It's about to become far more preventable!
@Drroxmehran and I teamed up for this @JACCJournals perspective
A "once-in-a-generation opportunity"
https://t.co/2KifJd2mfF

[Eric Topol @EricTopol]

To understand the biology of aging, extending healthspan and promoting longevity, females should be prioritized for research. The reproduction resilience hypothesis @CellCellPress @BuckInstitute
https://t.co/I4BbH9G3ig

[Anu Lala (Anuradha Lala-Trindade) @dranulala]

@JasonKatzMD @ShashankSinhaMD @HFSA @robmentz @noshreza I do!!!! Simply the best!

[Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 @DrMarthaGulati]

Thank you @DrHelenECollin1 for including me on this important paper. Understanding the impact of sleep disruptions on the cardiometabolic health of pregnant women provides insights to potential CV changes and need to be further studied
#cardioobstetrics @TheLancet @HMethodistCV @valeriaduarteMD @khurramn1 @WilliamZoghbi

[Journal of Cardiac Failure @JCardFail]

Hear from the guest editors leading The New Frontier of Heart Function in Women as they share their excitement for this upcoming focus issue.

📅 Submissions open through Sept. 15th: https://t.co/ReM9Vfry5W

#WomensHeartHealth #HeartFailure #CallForPapers

[Dr. Martha Gulati ♥️🫀❤️‍🩹🇨🇦 @DrMarthaGulati]

What’s in name?

#PMOS 🆚 PCOS: should translate into recognizing this is not a gynecological condition but rather affecting the cardio metabolic health of the women it affects &amp; translate into improved treatment

[Ankeet S. Bhatt, MD, MBA, ScM @ankeetbhatt]

New from the @ACCinTouch:2026 ACC Clinical Guidance on Adult Immunizations as Part of CV Care. Honored to serve as Vice Chair of this effort. Evidence growing that vaccines influence CV risk reduction not just infection prevention. In press @JACCJournals https://t.co/5emXtjAuie

[Journal of Cardiac Failure @JCardFail]

New science alert! Do AF, diabetes, or obesity change the benefits of aspirin withdrawal after HM3 LVAD?💖

This ARIES-HM3 analysis says no. Bleeding decreased without increases in stroke or thrombosis, even in these higher-risk subgroups.🩸

🔗https://t.co/sblfM10zbg

[Robert Mentz, MD @robmentz]

New HFpEF consensus pathway lays out clear approach:
💠SGLT2i + (ns)MRA, unless contraindicated
💠+GLP1, if obese
💠Consider ARNI
💠AVOID BB as able
CKM GL give framework in context of comorbidities.
🚨Need to make sure we don't delay effective therapies down the decision tree!🚨

[Mount Sinai Department of Medicine @DOMSinaiNYC]

In a recent @forbeshealth feature, Roxana Mehran, MD,shares her expert perspective on the FDA's approval of Lipfendrahis and what it means for patients, their cholesterol management, and why individualized treatment decisions remain essential.
Read more: https://t.co/L0FGnBCCBB

[Mount Sinai Department of Medicine @DOMSinaiNYC]

Department of Medicine's @dranulala, shares expert insight in Vogue on cortisol and the healthy habits that support overall wellness. Read more: https://t.co/cYeS1r6KcZ

[Anu Lala (Anuradha Lala-Trindade) @dranulala]

@ShashankSinhaMD @JCFINT @EdanZitelny @JasonKatzMD @noshreza @robmentz @ElliottMillerMD @BalimSenmanMD @aniket_rali @RanLeeMD @AndrewHigginsMD @AnnGageMD @jameshorowitzmd @carlosalviar Love this!

[John P Erwin III MD MBA MACC (#BigPoppy ) @HeartOTXHeartMD]

Amen

[Sahil Bloom @SahilBloom]

I'm convinced that real success is often quiet. It's spending less than you make. Driving the simple car. Wearing what you like. Loving the same person forever. Showing up for friends. Avoiding drama. Doing hard things. Real success doesn't shout. Quiet is seriously underrated.