Emere Demir

RNA biotechnology, Iowa Hawkeyes

[Emere Demir @EmereDemir]

@Morning_Joe @JoeNBC : it might be good to just visit Columbia University! Your description is wrong. The focus is one two things: divestment and ceasefire, not antisemitism. These are activities that Columbia and USA are involved in. Other wars do not involve Columbia/USA

[Emere Demir @EmereDemir]

Nice data which helps resolve m6A modifications in HIV genomic RNA: https://t.co/aCFzSu5lAL

[Stirling Churchman @fiddle]

Ever had a list of gene hits and not known what to do? Maybe GO enrichment left you wondering what your favorite gene is doing in your experiment? Check out GeneWalk, our #ML method that determines the relevant functions for each gene @robertietswaart (1/4)https://t.co/UpbAr96laM

[The Gilbert Lab @GilbertLabRNA]

mRNA structure is necessary and sufficient for mRNA modification with pseudouridine: https://t.co/BRU9iZfmgC Carlile et al. @NatureChemBio So, how are the mRNA structures themselves regulated..? We're seeking new students and postdocs to find out!

[Emere Demir @EmereDemir]

@RonBreaker @snmalkowski @YaleChem @RNAJournal I wonder if ATP or ADP is the endogenous regulator...based on the EC50’s it seems like a lot of potential ligands are present at the right concentration to control this riboswitch. Could it function to integrate a host of adenosine metabolites, rather than just one?

[Emere Demir @EmereDemir]

@yegracechen @HowardYChang Really interesting story, but hard to reconcile w/ Anderson paper saying that contaminants are the cause of immune responses. But still cool to see m6A can suppress immune responses in foreign circular (not linear) RNA. https://t.co/ZjWOkUJfr7

[Emere Demir @EmereDemir]

@Noncodarnia @rassobar @emboreports Interesting! I would have thought that RNA had a much more prominent role in establishing TAD boundaries.

[Emere Demir @EmereDemir]

Great paper which finally reveals binding preferences of eIF4E, the main cap-binding protein. https://t.co/cLA4E1JkPJ

[Wiley Interdisciplinary Reviews @WIREs_Reviews]

How do you identify RNA molecules that are subcellularly localized? This #WIREs RNA review by @JMTali summarizes classical and modern methods: https://t.co/Ah2S2HzUmK @rnabioco

[Ronald Breaker @RonBreaker]

Twisters! Litke and @SamieJaffrey describe in @NatureBiotech (https://t.co/GRS48nkjsx) how to make circular #RNA in cells using the "Tornado" method - a good #SynBio use for twister #ribozyme motifs. Now, why are there so many natural twisters? Image from Eiler et al., 2014.

[Ronald Breaker @RonBreaker]

Whiteley et al. @Nature paper on enzymes making new cyclic dinucleotides (https://t.co/ZsEnv3ImcC) forces an update to the possible #RNAWorld language list. Image from (https://t.co/T8kVoVRrdX) shows all possible standard c-di-NMPs; red means strong evidence of bio-relevance.

[Emere Demir @EmereDemir]

Can’t wait to read this and learn whether codon optimality is relevant in mammalian cells, and how it differs from zebrafish and yeast! High expectations, I know... https://t.co/JCXmZBJzy4

[Arrakis Therapeutics @ArrakisTx]

Scientists Take Aim at Disease-Causing RNAs Using Small-Molecule Drugs https://t.co/dmaFMS2PGH

[Emere Demir @EmereDemir]

Ingenious approach for expressing RNA aptamers (and shRNA, gRNA, mRNA, etc.) at high levels in cells! This expression method is a game changer. https://t.co/bbLZmOA46p

[Taekjip Ha @taekjip]

single molecule and structural biology collaboration on G quadruplex and helicase by Sua and Adrian's labs. https://t.co/CMwlqxnyWZ

[Emere Demir @EmereDemir]

@RNApreprints Certain codons are rare in E. coli and their presence is used to signal the presence of a viral invader and its RNA. So I think the RNA toxicity may be part of this defense mechanism.

[Chaolin Zhang @chaolinzhang]

Thank @james_gagnon for the nice preview, based on the preprint of the paper. https://t.co/QMmcu9X4ud

[WBUR @WBUR]

Startups are an engine driving the Boston area's #biotech boom.

And failures vastly exceed successes: https://t.co/S9XvVsfFio

[Emere Demir @EmereDemir]

@btnaughton @CarolynBertozzi Who would think a protein is bigger than the mRNA that encodes it? Seems obviously wrong. But I love the picture.

[Chaolin Zhang @chaolinzhang]

Glad to announce the release of CTK v1.0.8, a major update with various improvement, including improved stability and simplification of pipeline. Also features step-by-step tutorials for several major #CLIP protocols. #proteinrnainteractions, #CLIP, #CTK https://t.co/K5bP9JvswX