Why does PD-1 #immunotherapy sometimes accelerate the progression of #melanoma?
Studying mice and patients, the @hanks_lab identifies an #inflammasome axis that contributes to melanoma metastasis but can be targeted pharmacologically. @DukeCancer https://t.co/Hw3DL2NdvF
Countdown to a new star ⏳
Hidden in the neck of this “hourglass” of light are the very beginnings of a new star — a protostar. The clouds of dust and gas within this region are only visible in infrared light, the wavelengths that Webb specializes in: https://t.co/DtazblATMW
Very excited to share a new story from @kipnislab led by @Drieu_Antoine in collaboration with many others from within&outside our lab on parenchymal border macrophages (PBMs) in regulation of CSF flow with implications to aging and Alzheimer's disease || https://t.co/CbBWljpT2D
I am happy to share our recent work @CellReports. We uncover #Obesity enhances antiviral immunity in the genital mucosa through a #microbiota-mediated effect on #γδTcells.
Excellent work from @janghyun_park, @kangin1203, @HCEricKim!
https://t.co/lmjZDsUDW8
(1/15) My thesis work is out in @NatureComms (https://t.co/B7s7zlC1sM)!
We found that neuronal CaMKK2 causes checkpoint blockade resistance and reduces survival in preclinical glioblastoma (GBM), indicating that CaMKK2 may be a therapeutic target in #GBM.
Online now: Brain tumor cells can form a blood-tumor barrier (BTB) that limits drug penetration. In their paper, Chen & coll. show Piezo2 in tumor cells is involved in BTB formation and can be targeted to improve chemotherapy efficacy in mice.
https://t.co/Rb8awBrwvf
There has never been a better time to trust your gut feeling👀Two studies in Cell report that gut-innervating pain #neurons sense #bacterial presence to both shape the constituents of the gut microbiome and protect against excessive inflammation🦠 https://t.co/iW1MjTMHw6
#NatMetabPicks | In @Cell_Metabolism, the @AranyLab (@PennMedicine) use in vivo isotope tracing to show that cardiac branched chain amino acid (BCAA) oxidation increases in heart failure by lowering vascular resistance. #metabolism
https://t.co/uuWFZovLN7
The functions of oligodendrocyte precursor cells (OPCs) are not limited to oligodendrogenesis: OPCs engulf synapses during circuit remodeling in mice. https://t.co/T6hOWBDI7A
A new study in mice finds that colonization with S. aureus on the skin worsens systemic lupus erythematosus (SLE) by affecting #neutrophil behavior. @TohokuUniPR
Read more: https://t.co/FI8laHtArd
Kudos to @IdoAmitLab for the important new @NatureCancer work, in continuing our @Sys_Immunology@WeizmannScience journey to decode, understand and implement cancer immunotherapy for the benefit of humanity! https://t.co/AdAbnHOvXL