Epigeneticsfan

For those who love Epigenetics, we salute you

[Jonathan Weissman's Lab @JswLab]

Have you ever wondered exactly what happens when Cas9 creates a double-strand break? We're excited to share Repair-seq, an approach for screening how thousands of genetic perturbations change the mutations that cells make when they repair DNA damage. https://t.co/bZvLLlLCSP

[Mick W@tson ↙️ @BioMickWatson]

The human genome

[Epigenetic Hulk @epigenetichulk]

TAD! OCT4! PLURIPOTENCY! PHASE SEPARATION! REPROGRAMMING! THIS WIN EPIGENETIC BINGO! https://t.co/Nc7n7IEpO0

[Patrick Cramer @mpgpresident]

Nuclear condensation of transcription factor NELF drives downregulation of genes upon stress.
Great collaboration of Marc Boehning @mpibpc with @rawatravans and Ritwick Sawarkar @mpi_ie @MRC_TU
Now online: https://t.co/UT1q4ao1Hh

[Gene Regulation @generegulation]

Evidence of widespread, independent sequence signature for transcription factor cobinding https://t.co/mSsZUOOtzr
Motifs associated with TF-TF co-binding:
(1) TF-pair specific (see table)
(2) TF-specific (see table)
(3) TF-generic (e.g. GABPA, JUND, TAF1, and HNF4A)
#TFbinding

[Gene Regulation @generegulation]

Two papers show that depletion of H1 histones decreases H3K27me3, increases H3K36me3, affects Hi-C, shifts B-to-A compartments

Willcockson et al., H1 and the epigenetic landscape
https://t.co/eBumyYyDz3

Yusufova et al, H1 and 3D chromatin in lymphoma https://t.co/or1dfvYhDP

[Manuel Irimia @mirimiam]

Our first pre-print on early development and splicing! A developmentally programmed splicing failure attenuates the DNA damage response during mammalian zygotic genome activation. https://t.co/q5Z8GMfqaL. By @Wyatt1Chris, @BPernaute et al (@bogdanoviclab). @CRGenomica. Summary👇

[Feng Yue @yuefeng_1]

Our work on zebrafish epigneome/3D genome/sex chromosome is available @nature. Transcriptome, methylome, ATAC-Seq, candidate enhancer/silencer across 11 tissues. Great collaboration with @twang5,@rosshardison,Topczewski/Kai Wang/Glenn Gerhard/Keith Cheng. https://t.co/CGY1pyCOim

[Victor Corces @CorcesVictor]

Interesting paper and technique

HiCAR: a robust and sensitive multi-omic co-assay for simultaneous measurement of transcriptome, chromatin accessibility, and cis-regulatory chromatin contacts https://t.co/nhJzbCBjsl

[Nature Genetics @NatureGenet]

Remembering José Luis Gómez-Skarmeta @jlgomska, by @bogdanoviclab
and @mirimiam https://t.co/gwbhTSgOZG

[SEBD @SEBiolDev]

Jose Luis Gómez-Skarmeta was a great mentor for his lab fellows and many of them play today leading roles in Developmental Biology. In his recognition and memory, the SEBD will name its award for junior scientists after him. Aply at https://t.co/YmUWvOHNMM before Oct 1st

[@dariloops.bsky.social @Dariloops]

Words cannot describe the painful loss of @jlgomska

Inspiration, mentor and role model for young scientists. Pioneer in science and a GOOD MAN.

I thank life for the oportunity of meeting him as friend and collaborator. Science will never be the same without you, José...

[Manuel Collado @mcollado_CIMUS]

Really sad to hear about the passing of JL Gómez-Skarmeta. One of the most original and innovative scientists, always leading the most provocative and advanced science projects. A great loss for science

[Neil Shubin @NeilShubin]

With crushing sadness: my colleague and dear friend. Far too soon. RIP José Luis Gómez Skarmeta.

[Victor Corces @CorcesVictor]

I'm devastated to learn that Jose Luis Gomez-Skarmeta passed away today. One of the most imaginative scientists I've known. His sense of humor and perpetual smile made me happy every time I saw him. We will always miss you, Jefe!😭

[Raquel @Raquel_riera]

Challenge #WearAMask by @WHO accepted! Nominada por @nuriapelaez y reto a @Juditpvalero @visetta82 @martaclotet0 @Marta_Soler_ @AuriaAB. Aquí a la ofi us espero compis 🔥 (a algunes 😉)

[Shiv Grewal @grewalsh]

“Heterochromatin for stress adaptation”
Additional evidence showing that facultative heterochromatin promotes adaptive genome control in response to unfavorable growth conditions, as also reported previously in https://t.co/NYLSZmV71T

[Ben Lehner @BenLehner]

The age at which you can first have sex is controlled by what your mom smelt. @MfPez @francemirko @CRGenomica
https://t.co/ImSyQHMEWY

[Fran Supek @FranSupek]

David's @davidmasp cool paper is out in @NatureGenet!

We identified a pattern of #mutation clustering in cancer #genomes, distinct from the known 'mutation showers'⛈️

We think one cause of such 'mutation fog'🌫️is DNA repair + APOBEC3A activity

read more https://t.co/dpdYOE45OR