George Watase

Postdoc with @yamashitaflylab at @WhiteheadInst studying how vulnerable but essential rDNA repeats are maintained across generations.

[George Watase @GeorgeWatase]

Our paper with @J0Nelson and @yamashitaflylab is finally out from @ScienceAdvances! We show that nonrandom sister chromatid segregation functions in rDNA copy number maintenance in germline, contributing to “germline immortality”! https://t.co/wlZtIqtcRC

[George Watase @GeorgeWatase]

I’m very proud of my student, Taichi Hyodo, for receiving the excellent poster award at the annual meeting of the Japanese Society of Developmental Biologists. Congrats, Taichi!

[HHMI @hhmi_science]

HHMI Investigator Yukiko Yamashita’s (@yamashitaflylab) work in fruit flies has brought a fresh perspective to a longstanding question in stem cell biology. The work offers a new look into how stem cells stay immortal.

Read more at the link below! https://t.co/FAbVRxTp3x

[George Watase @GeorgeWatase]

@TatsuKono たつさん、身に余るお言葉をいただき、大変恐縮です。これからもたつさんの近くで色々と交流していきたいと思っています。これからもよろしくお願いいたします。

[George Watase @GeorgeWatase]

@CameronWBerry Thank you, @CameronWBerry

[King L Hung @kinglhung]

Thrilled to share our paper in @NatureGenet! Cancer cells often amplify oncogenes outside chromosomes. We can now isolate and profile these large circular extrachromosomal DNA (ecDNA) molecules using a method called CRISPR-CATCH. 1/10
https://t.co/8BdOY4DL4G

[George Watase @GeorgeWatase]

@zz_zhaozhang @yamashitaflylab Thank you!!

[Lasker Foundation @LaskerFDN]

Indra, a previously uncharacterized zinc finger protein, binds to rDNA to mediate nonrandom sister chromatid segregation (NRSS). This is the first evidence that NRSS is directed by a specific chromosome region. https://t.co/4PcDMEqI4x
@yamashitaflylab @GeorgeWatase

[George Watase @GeorgeWatase]

@LabSantoro @J0Nelson @yamashitaflylab @ScienceAdvances Thank you!

[George Watase @GeorgeWatase]

Our paper with @J0Nelson and @yamashitaflylab is finally out from @ScienceAdvances! We show that nonrandom sister chromatid segregation functions in rDNA copy number maintenance in germline, contributing to “germline immortality”! https://t.co/wlZtIqtcRC

[George Watase @GeorgeWatase]

@suehammoud1 @ollie_rando @J0Nelson @yamashitaflylab @ScienceAdvances Thank you, Sue!

[George Watase @GeorgeWatase]

@MaikoKitaoka @J0Nelson @yamashitaflylab @ScienceAdvances Thank you, Maiko!! Almost 3 and half years have passed since you wrote wonderful preLight highlight on our first version of preprint.

[George Watase @GeorgeWatase]

@FlyJagannathan Thanks, Madhav!!

[George Watase @GeorgeWatase]

@JoseTelesReis @J0Nelson @yamashitaflylab @ScienceAdvances By interfering the process, germline is not able to recover the copy number and continuously loses rDNA copy number over generations, leading to extinction of the lineage. Hope this explanation would help for you! 4/4

[George Watase @GeorgeWatase]

@JoseTelesReis @J0Nelson @yamashitaflylab @ScienceAdvances sister chromatid with increased rDNA copy number generated by unequal sister chromatid exchange is preferentially retained by daughter germline stem cell (GSC) in asymmetric GSC division. 3/4

[George Watase @GeorgeWatase]

@mayuinaba0317 @J0Nelson @yamashitaflylab @ScienceAdvances Thank you, Mayu-San! It was long long journey!

[George Watase @GeorgeWatase]

@nwarsingerpepe @J0Nelson @yamashitaflylab @ScienceAdvances Thank you, Natalie!!

[George Watase @GeorgeWatase]

@peiwei_chen @yamashitaflylab @J0Nelson @ScienceAdvances Thank you, Peiwei!

[George Watase @GeorgeWatase]

@TakashiAkera @yamashitaflylab Thank you, Takashi!

[George Watase @GeorgeWatase]

@OdedRechavi @J0Nelson @yamashitaflylab @ScienceAdvances Thank you!