Jian-Hua Chen

Soft x-ray tomography/Bio-imaging/3D Tomography/Correlated cryo-light and SXT Staff Scientist at NCXT/LBNL/UCSF

[CryoCapCell @CryoCapCell]

You can find our technologies in China! Martin is there with our new machine for Freeze substitution❄️ without liquid N2! (please see the second and third photos). Can't wait to deliver it to you! #EM #CLEM #electronmicroscope @AcadSinica

[Stephanie Moon @smslmoon]

Max’s review, “Stress granules as causes and consequences of translation suppression” is online!

#stress #RNA #translation @maxbaymiller

Access on our website: https://t.co/LqdBs3Dja2

[Mark Pownall @MarkPownall5]

Our work describing Chromatin Expansion Microscopy is now out in @ScienceMagazine https://t.co/ysL8Q1xmqA Check out how we were able to visualize transcription, chromatin, and TFs with molecular resolution in developing zebrafish embryos to understand gene regulation!

[Soft X-Ray Imaging @SiriusXT_Ltd]

Three #PhD positions open
@ucddublin to demonstrate benefits of #SXT in Correlative Imaging #CLEXM for disease research and drug delivery. The project is funded by #MSCA Doctoral Networks. Apply via https://t.co/hcaiBxzwG9 #PhDposition 🙏Please retweet

[Nature Cell Biology @NatureCellBio]

Read also the N&Vs article on the study written by Simon Alberti & Serena Carra.
https://t.co/Yvp6gREzen
https://t.co/4VK3rByEER

[Nature Cell Biology @NatureCellBio]

☕️NEW: @FrydmanLab @EmSontagMU @FaboPolanco & co show that nuclear & juxtanuclear misfolded proteins converge to opposite nuclear envelope sides, proximal to nuclear–vacuolar junctions for ESCRT-dependent egress to the vacuole.
https://t.co/DdNfaP1LNf https://t.co/EGfd9dKtuP

[Frydman Lab @FrydmanLab]

Out today at Nature Cell Biology our exciting story defining the coordination between cytoplasmic and nuclear spatial protein quality control: https://t.co/m5SgoEtZk9. Congratulations to @EmSontagMU and @FaboPolanco !!!

[EmSontagMU @EmSontagMU]

It could! We see cytoplasmic misfolded protein compartments interacting with vacuoles and deforming the vacuolar membrane, almost like they are being pulled in to the vacuole. #proteinclearance #autophagy #vacuole 5/12

[EmSontagMU @EmSontagMU]

IT'S FINALLY HERE! A story years in the making about how cells handle misfolded proteins in the nucleus and cytoplasm 1/12
#proteostasis #proteinfolding https://t.co/2F6cRe7Yti

[Volodymyr Nechyporuk-Zloy @vnzloy]

"Cellpose: A generalist deep learning algorithm for cell and nucleus segmentation
https://t.co/lBsRk5hxba"

[Viruses MDPI @VirusesMDPI]

Soft X-ray #Tomography Reveals #HSV-1-Induced Remodeling of Human B Cells

Chen et al. demonstrate the power of #SXT imaging for scouting #virus-induced changes in infected cells and understanding the orchestration of virus-host remodeling quantitatively

https://t.co/8q2Y2vNg6U

[Kamal Nahas @KLNahas]

Excited to share our new preprint is out! We're exploring the utility of X-ray tomography for virus research 🦠🧪. Collab between @AtomicVirology, @B24Light and the Colin Crump Lab.
A tweetorial (1/12)
https://t.co/XCachAh8dh

[Jian-Hua Chen @Goebernan]

@DrHorrell

[Serena Sanulli @seresanu]

Our protocols for in vitro phase separation assays are out! Check it out 👀👀👀

[brangwynnelab @brangwynnelab]

Excited to see our SARS-CoV-2 syncytia paper finally out in eLife. Congrats to @DavidWSanders2 @LeventalLab @PlossLab and all our amazing collaborators: https://t.co/HFS53ze3Et

[Nature Plants @NaturePlants]

An exciting collection on Phase Separation in Biology from our colleagues at @NatRevMCB . And it includes one of our papers: "The Structural Basis of Rubisco Phase Separation in the Pyrenoid" from @JonikasLab

https://t.co/q1VCkKryYn

[Hotamışlıgil Lab @gshlab]

New paper on a groundbreaking study of stress response in liver cells is out in @Cell_Metabolism Congratulations to Gökhan S. Hotamışlıgil, Amir Tirosh, Gürol Tunçman, Ediz Calay, and others for their wonderful work. ⁦@ghotamis @MET_HSPH @HarvardChanSPH
https://t.co/IfCyKb5gsp

[Gökhan Hotamışlıgil @ghotamis]

After years of hard work, Güneş @gparlakgul & Ana @apsarruda have successfully produced spectacular resolution of the inner architecture of liver cells, compared lean/obese liver tissue, & demonstrated the impact of architecture on metabolic function.https://t.co/MuaYlCbmxF

[Julie Faitg, Ph.D. @JuFaitg]

Excited to share the Preprint in collaboration with @MitoPsychoBio «3D Neuronal Mitochondrial Morphology in Axons, Dendrites, and Somata of the Aging Mouse Hippocampus» https://t.co/J4jQ9QaDCZ
@MitoResearch @mitomusclelab @EMRSncl

[Alister Burt @AlisterBurt]

Optimal cryo-ET and subtomogram averaging workflows can be a pain - we put together a little toolkit which simplifies working between Warp-RELION-M and Dynamo, providing automation where possible and more flexibility if needed! 1/n https://t.co/1lFQ4XGlvc