Sebastian Greiss

Genetic code expansion, optogenetic tools, behaviour in C. elegans at the University of Edinburgh

[Sebastian Greiss @GreissLab]

Check out our Breakthrough Article in @NAR_Open where we use a quadruplet codon to expand the genetic code of an animal. @EdinburghUni @CDBSEdinburgh @SynthSysEd @ERC_Research
#Celegans
https://t.co/ZkZq5N515K

[Kathrin Lang @klanglab]

Check out our new paper for site-specific labeling proteins and building defined Ub/Ubl-protein conjugates using a plant Asp-endopeptidase.
Great effort by @MaxFottner @jhmgrtnr @MaxGantz_ @RaMue1304 and @NkTimon! Congratulations to all!👩‍🔬👨‍🔬🤩🙌🥳

[ChemBioChem @ChemBioChem]

Generation of Photocaged Nanobodies for Intracellular Applications in an Animal Using Genetic Code Expansion and Computationally Guided Protein Engineering (Greiss) @GreissLab, @jack_oshea97 #openaccess https://t.co/LsAPBv5ypo

[Christian Froekjaer Jensen @wormbuilder]

1/7 Try our new app for optimizing transgenes for C. elegans expression (https://t.co/fFPIYVgnbB). The app uses algorithms from collaborators Henrik Bringmann (TU Dresden) and Dan Dickinson (UT Austin) - or codons from highly expressed ubiquitous genes.

[Christian Froekjaer Jensen @wormbuilder]

1/5 Our paper is out as a bioRxiv preprint. @sonia_elmouridi and @FaisalMAlkhaldi Like MosSCI, just better. Targeted single-copy and array integration synthesizing new and gradual improvements from the past 15 years across many labs. https://t.co/sgjevIiLfs

[Stephen Wallace @Dr_StephenW]

Come and join us @Wallace_Lab @SBSatEd for your PhD in #biotechnology, investigating the use of #microbes to produce industrial chemicals from sustainable feedstocks and waste with @LubrizolCorp. Fully-funded studentship to start Oct '22 @SynthSysEd

https://t.co/YuITGL25a5

[Kathrin Lang @klanglab]

Now in its final format and online as a hot paper 🔥😀
A great collaboration with the @SieberLab to profile the substrate scope of hClpP via genetic code expansion, photocrosslinking and proteomics!
Congrats Anh, Thomas, Timon and everyone involved!! 🙌

[Stephen Wallace @Dr_StephenW]

The Funding Elves have been good to @Wallace_Lab in December 🎁 We'll be advertising for 5 PDRAs (1 with @JoSadler10) and 1 fully-funded PhD at the start of 2022. DM or email me with a cover letter and CV if you're interested in joining us @SBSatEd @SynthSysEd 🧫🧬🧪

[Sebastian Greiss @GreissLab]

Then we use the quadruplet to incorporate photocaged cysteine into a caspase for light induced ablation of C. elegans neurons.

[Sebastian Greiss @GreissLab]

Check out our Breakthrough Article in @NAR_Open where we use a quadruplet codon to expand the genetic code of an animal. @EdinburghUni @CDBSEdinburgh @SynthSysEd @ERC_Research
#Celegans
https://t.co/ZkZq5N515K

[Sebastian Greiss @GreissLab]

We use photocaged lysine to express photocaged Cre recombinase for optical control of gene expression. Here the UAGA quadruplet works as efficiently as a UAG triplet.

[Maria Doitsidou @Doitsidou_lab]

Interdisciplinary EASTBIO PhD project available on drug resistance and human fungal pathogens combining #Calbicans, #Celegans, and #Bioinformatics
@Makrantoni_lab
@r0bah0lic
@EdinburghUni
Only few days left to apply!! Deadline Dec 15.

https://t.co/BN03CoCTo5

[Gram Hansen Lab @gram_lab]

PhD studies? Come join us!
@EdinUni_MeetCIR @EdinUni_IRR.
https://t.co/3llAWyYS1D
🔬🧫🧪🧬

[Kathrin Lang @klanglab]

Check out the early view of our new article in @angew_chem!
A fantastic collaboration with the @SieberLab to profile the substrate scope of mitochondrial caseinolytic protease P via site-specific photocrosslinking 🧪💡🧫🧑‍🔬🧑‍💼
Congrats to Anh and Thomas! 🙌
https://t.co/wnAMiE58kD

[Abhishek Chatterjee @AChemSynBio]

Excited to share this new preprint! We optimized a directed evolution strategy to engineer E. coli tyrosyl-tRNA synthetase for genetically encoding new unnatural amino acids in mammalian cells, including a nonhydrolyzable phosphotyrosine mimic https://t.co/eLH4nrbpQY

[Vasso Makrantoni @Makrantoni_lab]

Interested in drug resistance and human fungal pathogens? Apply for our interdisciplinary EASTBIO PhD project to join us at @UoE_IM. Co-supervisors @Doitsidou_lab @r0bah0lic. Fully-funded, international applicants. Please RT! #Calbicans #Celegans
https://t.co/hQywTXmvDc

[Kathrin Lang @klanglab]

Playing Lego with ubiquitin: 🧱🧪🧬 Building complex Ub/Ubl chains using orthogonal sortases.
Great work led by @MaxFottner 👏 with help from @mariaweyh and Dominic! Many thanks to Stefan and @Michael13120606 for the NMR-collaboration! 🥳🥂@ERC_Research
https://t.co/WyohCFH8dW

[Stephen Wallace @Dr_StephenW]

Check out our recent work with @lehorsfall on the use of microbial Pd nanoparticles and membrane-bound micelles for chemical synthesis. Microbes are amazing chemists! @SynthSysEd @SBSatEd @EdinburghChem https://t.co/ukt5yd0gPN

[Sebastian Greiss @GreissLab]

Our paper on improved genetic code expansion and using a laser to control gene expression in C.elegans is out. Congrats to lab members Lloyd Davis @aggelikigoutou @AilishTynan Kieran Baxter, Zhiyan Xi @jack_oshea97
@EdinburghUni @CDBSEdinburgh @SynthSysEd
https://t.co/Xu0LF9haid