SheriHarari

[Burstein lab @BursteinLab]

Imagine you’re a plasmid conjugating into a recipient cell. How would you overcome CRISPR-Cas and other bacterial defense systems? Encoding anti-defense mechanisms is one obvious way.

But where? And how? @BruriaSamuel set out to explore! 🧵 1/6

https://t.co/dsf3U0bsjs

[Bloom Lab @jbloom_lab]

Contrast below Tweet w one in tweet 22 of same thread by @veeslerlab

XBB.1 only has ~4-fold decrease in antibody *binding* to RBD but ~100+ fold decrease in *neutralization*

Underscores how SARS-CoV-2 preferentially evolving to escape antibody neutralization rather than binding

[Nextstrain @nextstrain]

We're happy to announce that https://t.co/V6wjsrjajZ now has weekly updated #RSV analyses:

https://t.co/7B4a5NXogU

Thanks to Laura Urbanska at @unibasel_en, who has set up a full genome analysis, as well as analyses focusing on the genes G and F for RSV A & B.
[1/3]

[Richard Neher @richardneher]

too bad this study wasn't posted on a preprint server -- the community would have had an opportunity to discuss the data and give feedback to the authors before it ends up in final form in a journal. 5/5

[Dr Emma Hodcroft @firefoxx66]

Huge congrats to @richardneher for receiving the 3rd Symposium for Emerging Viral Diseases @gcevd Award! So well deserved for tireless hard work during the pandemic and on @nextstrain!
For his award lecture he will speak on adaptive evolution in #influenza & #SARSCoV2.

[Bloom Lab @jbloom_lab]

In new study, we examine evolution of #SARSCoV2 mutation spectrum. https://t.co/KkcVh7UUEg

TLDR: There have been changes in relative rates of mutations during SARSCoV2’s evolution, & mutation spectrum is becoming more similar to other sarbecoviruses.

Thread below.

[Dr Emma Hodcroft @firefoxx66]

🎉Coming in 2023: The Hodcroft Lab!!🎉
I'm so so excited to announce that my @snsf_ch Starting Grant was funded!
I'll be focusing on the amazing world of #Enteroviruses at the fantastic @SwissTPH as an Assistant Prof!
💰👩🏻‍🎓🦠🧬

Schweiz, ich bleibe! 🇨🇭❤️

1/3

[SternLab @sternadi.bsky.social @SternLab]

האם נכנסנו לשלב ה״אנדמי״ של המגיפה (מושג מורכב בפני עצמו)?כן ולא. סיכום קצר שלי, שווה לקרוא את כל הטקטס למטה. אחוזי התמותה צנחו תודות לחיסונים והדבקות קודמות. מצד שני, הדעיכה של ההגנה גורמת למספר הדבקות עצום בכל גל ולכן עדיין יהיה מספר רב של חולים קשים וגם מקרי מוות.

[Dr Emma Hodcroft @firefoxx66]

🎉The new and improved https://t.co/wVE7ucgcg6 is here! 🎉

We're hoping to make this a one-stop location to track not only the 'headline' variants, but many different #SARSCoV2 mutations & variants that scientists are keeping an eye on.

Let's take a tour of the site!

1/12

[Bloom Lab @jbloom_lab]

Paper by @gonzalezreiche Sordillo @VivianaSimonLab van Bakel et al showing onward transmission of highly mutated #SARSCoV2 variant that evolved in chronic infection. This may be first explicitly documented example of transmission from chronic infection https://t.co/5nNqqG0z5j

[Trevor Bedford @trvrb]

We're now starting to see the evolution of new potentially impactful sublineages of Omicron with particular focus on mutations at spike residue 452. Here, I'd like to highlight lineages B.2.12.1 in New York, as well as BA.4 and BA.5 in South Africa. 1/17

[SheriHarari @HarariSheri]

@SternLab החלמה מהירה לכולכם, שיעבור בקלות♥️

[SheriHarari @HarariSheri]

I was very lucky to take a part in this amazing project, if you what to know what makes a new variant of concern- take a quick look😊

[SternLab @sternadi.bsky.social @SternLab]

Where do variants of concern come from?
In a study led by @SheriHarari we compared mutations across 27 chronic infections, 🧵 below :
https://t.co/4BflURlHKK. TL;DR: we think a trade-off between immune evasion and transmissibility constrains evolution in chronic infection.

[Arad Nir @arad_nir]

הערב הבאנו את תוצאות הריצוף הגנטי שביצעה ⁦@SternLab⁩ לנגיף הקורונה בישראל.
70% מההדבקות בישראל מקורן ⁦⁩בארה״ב! 30% מאירופה. הנגיף הגיע בסוף ינואר ולהערכתה לא יותר מ-1% מהישראלים נחשפו לCovid-19.

https://t.co/bwKtcQAnYr

[SternLab @sternadi.bsky.social @SternLab]

Great work Guy and @Daniellemlrs with @ras_nielsen now out: https://t.co/3iME9xzS5j

[SternLab @sternadi.bsky.social @SternLab]

we are on a biorxiv spree.... check this out, cool & super easy method to find real mutations from MinION sequencing, with @ugophna :
https://t.co/bPzlQu1COt

[SternLab @sternadi.bsky.social @SternLab]

Take a look at Tal's cool new paper!! https://t.co/LYfq2Jk6wB

[SternLab @sternadi.bsky.social @SternLab]

Happy Purim from the Stern Lab!! #Purim

[SternLab @sternadi.bsky.social @SternLab]

@SternLab Fun Day! with our best two favorites - wine and chocolate!