@HinczewskiLab

Associate professor at @PhysicsCWRU: theoretical biophysics, statistical mechanics, random stuff (literally).

[@HinczewskiLab @hinczewskilab]

Check out our new preprint on the connections between machine learning and nonequilibrium physics: https://t.co/R6hNMOd7e5. Shishir Adhikari started this as his last PhD work, and it has grown into a fun collaboration with @AlkanKabakciog1, Alex Strang, and @denizyuret (1/n)

[efe ilker @efephys]

Beautiful story of discovery #microRNA

[Ben Kuznets-Speck @benkuznetsspeck]

My colab with @DeWeeseLab and Adri Zhong is out @PhysRevE ! https://t.co/kdHpodDP9z Here we provide the theoretical foundation for stochastic normalizing flows and show how to efficiently sample free energies with counterdiabatic driving! Retweet and check it out!

[KerryGeilerSamerotte @KSamerotte]

Is there more than one mechanism underlying resistance to an antifungal drug? How many mechanisms are there? @KaraSchmidlin and @SamApodaca_ explore these questions in their paper out today in final form at @eLife! https://t.co/lJDsNSgIso (1/9)

[@HinczewskiLab @hinczewskilab]

@UAGurkan @NatureComms Congrats to the whole team on a massive effort, particularly @utkugoreke on the experimental end and @PhysicsCWRU grad students Ayesha Gonzales (@a_idelina) and Brandon Shipley on the ML data analysis!

[Umut A. Gurkan @UAGurkan]

Thrilled to share our new paper published today in
@NatureComms: "Motion blur microscopy: in vitro imaging of cell adhesion dynamics in whole blood flow"

Motion Blur Microscopy (MBM) integrates microfluidics and light microscopy with #AI to provide a low cost, easy to implement alternative to intravital microscopy. We use MBM for visualizing cellular interactions, adhesion, and motility in whole blood flow. MBM is generalizable to studies of various diseases, including blood disorders, cancer, thrombosis, inflammatory and autoimmune diseases. MBM provides rich datasets for theoretical modeling of cellular adhesion dynamics in complex media.

Congratulations to all authors: @utkugoreke, Ayesha Gonzales, Brandon Shipley, Madeleine Tincher, @oshin_1309, @WWulftange, @YunchengMan, @RanAnPhD, @hinczewskilab

@cwru, @CaseEngineer, @CWRUartsci, @PhysicsCWRU, @CWRU_MAE
👇
https://t.co/zfrzpQxZyz

[Jake Scott @CancerConnector]

So fun! @PRX_Life chose our work for their first cover! Congrats @JeffMaltas and team!

[Jeff Maltas @JeffMaltas]

Incredibly excited that our paper examining the role of ecological interactions in preexisting drug resistance is out! We tackle the apparent paradox between the cost of resistance in the absence of treatment, and the ubiquity of preexistence. 1/20

Link: https://t.co/0rIuh1OIfx

[Jake Scott @CancerConnector]

Excited to share new paper led by postdoc @JeffMaltas (on the job market!) out today in @PRX_Life (1/4 🧵)

Frequency-Dependent Ecological Interactions Increase the Prevalence, and Shape the Distribution, of Preexisting Drug Resistance

#cancer #ecology

https://t.co/OQ8TtZFYZv

[Aykut Erbas @AykutErbas3]

1/3: Paper Alert! How does chromatin phase segregation influence nuclear morphology in eukaryotic cells??? Many genetic diseases with dominant epigenetic alterations also show nuclear-scale changes in 3D genome organization accompanied by nuclear-shape abnormalities...

[Nadir Kaplan @cnadirkaplan]

We propose that the well-known concept of colloidal diffusiophoresis can also be manifested in hydrogels, offering a way to speed up gel deformations (that can otherwise be really slooow).

https://t.co/6qricRVJFN

[Pino Strangi @PStrangi]

Check out our perspective paper on AI strategies for optimizing additive manufacturing in nanophotonics! #AI #AdditiveManufacturing #Nanophotonics

[@HinczewskiLab @hinczewskilab]

@QiweiYu2 @phybiofunc Thank you for organizing a really fun visit!

[Jake Scott @CancerConnector]

Excited to share the labs newest @PNASNews publication

Reinforcement learning informs optimal treatment strategies to limit antibiotic resistance

from @cwrumstp student (and CWRU systems biology graduate excellence award winner!) Davis Weaver & team 🧵

https://t.co/sjPv7duVzX

[@HinczewskiLab @hinczewskilab]

Thank you to @QuinnPhysics, @gstarkman, and Deyan Mihaylov for roping me into the project!

[@HinczewskiLab @hinczewskilab]

Quite fun and unexpected collaboration! A chance to do some of my favorite kinds of statistical physics (random walks and first passage calculations) at insanely different scales than I'm normally used to as a biophysicist (Planck-sized🤏black holes).

[CWRU Physics @PhysicsCWRU]

@cwrusgs student Quinn Taylor, Prof. @gstarkman, Prof. @hinczewskilab, postdoc Deyan Mihaylov, & collaborators have submitted "Extremal Kerr Black Hole Dark Matter from Hawking Evaporation" to the arXiv. 👏 Full text: https://t.co/kW8Y5KOcft

#cosmology #cwru @cwru @cwruartsci

[Felix Rico @felix_rico]

Please RT. We are looking for a motivated PhD candidate to work on the biophysics of protein condensates with high-speed atomic force microscopy 👇🏾 @FM4B_Lab in collaboration with Mauro Modesti @crcm_marseille
@univamu @Insermpacacorse @AgenceRecherche
https://t.co/ZZUEbrbw49

[Artemy Kolchinsky @artemyte]

Our paper with @JordiPinero and @ricard_sole is out! We consider the problem of finding the nonequilibrium steady state that optimizes free energy harvesting + illustrate it on the amazing photosynthetic bacteriorhodopsin system. A long time in the making ...

[Jake Scott @CancerConnector]

Eshan is on a roll! New preprint from this future #physicianscientist @cwrumstp

https://t.co/JRKplzXYeC

Ever want to do some evolutionary simulations and need to know the death rate?? It’s a hard problem - made harder because most assays are blind to it…

Thread -

[efe ilker @efephys]

How do bioenergetic costs of microRNAs depend on interaction strengths? Our work (now in PNAS) reveals an energetically optimal affinity range for microRNA-mRNA interactions (which coincides with 7 nucleotide complementarity!)-w/ @HinczewskiLab @PNASNews #Bioenergetics #microRNA

[Pino Strangi @PStrangi]

Check out the latest research project led by Flynn Zhi and Andy Lininger! They've had a blast manipulating random lasing correlations in doped liquid crystals. @PhysicsCWRU @nanoplasmc #OSA_OL https://t.co/ZiknTVvLRF #Photonics #Innovation