Huan Edmonds

Postdoc in the Zhang lab at @broadinstitute and @MIT. Previously @ElowitzLab at @Caltech. Used to go by Grace Chow. 🧬 I luv SynBio!

[Huan Edmonds @HuanEdmonds]

Can we use RNA to insert kilobases of DNA into the human genome, opening up a new way to engineer cells or treat disease?

Excited to share our latest work turning a retrotransposon (a “jumping gene” with an RNA intermediate) from songbirds into a genome editing tool. 🧵 (1/7)

[Katie Galloway @GallowayLabMIT]

Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)

[Michael Baym @baym]

Hot off the press! Our latest paper led by @fernpizza , understanding how plasmids evolve inside individual cells. These small pieces of self-replicating DNA live inside bacteria and can transfer antibiotic resistance genes, but they also compete with one another to replicate. 1/

[Max Wilkinson @maxewilkinson]

The Wilkinson Lab is open for science! @MSKCancerCenter

🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬

[Katie Galloway @GallowayLabMIT]

🚨New paper alert!🚨 Cells integrate signals into decision-making. But how do levels of signaling influence cell-fate transitions? Is more always better? Or is there an “optimal” level for cell-fate programming? If we could tune signaling, could optimize production of neurons? Read on! (1/n)🧵

[Huan Edmonds @HuanEdmonds]

@AkankshaThawani @Columbia Congrats Akanksha!!

[Huan Edmonds @HuanEdmonds]

@Akash_Guru_ Akaaaash! Thank you!

[Huan Edmonds @HuanEdmonds]

@KalliKappel Thank you Kalli!!

[Huan Edmonds @HuanEdmonds]

@WangXiaoLab Thank you so much Xiao! And for the fun and helpful discussions along the way!

[Huan Edmonds @HuanEdmonds]

Can we use RNA to insert kilobases of DNA into the human genome, opening up a new way to engineer cells or treat disease?

Excited to share our latest work turning a retrotransposon (a “jumping gene” with an RNA intermediate) from songbirds into a genome editing tool. 🧵 (1/7)

[Huan Edmonds @HuanEdmonds]

@GallowayLabMIT Thank you so much Katie!!

[Huan Edmonds @HuanEdmonds]

Full story here! https://t.co/Z5CPbS3Ett

We hope this expands the toolkit of retrotransposon-based gene editors. Also, don’t miss related work from others like @CollinsRNPLab, who have also illuminated how R2 can be used for mammalian genome engineering. (7/7)

[Huan Edmonds @HuanEdmonds]

This project was a huge team effort. Shoutouts to:
@maxewilkinson: structure + biochemistry + birb animation 🐦‍⬛🥚
@HongyuChenChem and @LDangliang: RNA chemistry
@zhangf: incredible mentorship
… and all the amazing authors that worked tirelessly to make this possible. (6/7)

[Kalli Kappel @KalliKappel]

In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput method to measure nuclear condensate formation & applied it to ~14000 IDPs to find out
https://t.co/qfa8jtvFOp

[Huan Edmonds @HuanEdmonds]

@xinjin Congratulations Xin!!

[Cell @CellCellPress]

In the latest issue! Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxins https://t.co/K28mhsVQzH

[Huan Edmonds @HuanEdmonds]

The amount of bizarre political advertisements on my feed is getting out of hand 😳 is it finally time to swap platforms? I am https://t.co/xtgwr0YJuM, I’ll try to re-add people there too (this feels like getting a new phone in the 2000s).