Jan HM 🪷

Assabentant-me de tot, sobretot del drama | 👨🏼‍🔬PhD fellow @Casanova_Acebes | 🔎 immune clones 🧫🌳 in breast cancer metastasis @CNIOStopCancer ~🇪🇸🇩🇪🇪🇺

[Jan HM 🪷 @JHXII_13]

Tant de bo estar ahí al teu costat, abraçar-te, donar-te tot l'amor que em fas sentir per la vida, en la que estem junts des de ja tant de temps i en la que romandrem fins sempre 🌸🍒

[Satchin Panda @SatchinPanda]

The testis may be one of the body's most rhythmic organs. Using single-cell sequencing, researchers found that key testicular cell types follow daily circadian programs, with germ cell development peaking at night. Disrupting circadian rhythms impaired fertility, highlighting the critical role of biological timing in reproduction. ⏰🧬 #CircadianRhythm #Fertility #Chronobiology
https://t.co/eTTVmrHYup

[Arjun Raj @arjunrajlab]

Super excited to share this paper from @O_Farrell_Aoife!

[Trends in Immunology @TrendsImmuno]

Scaling immunity: sickness as a host defense strategy https://t.co/A7G2fLi9XC

[Trends in Immunology @TrendsImmuno]

Bioelectric signaling as an emerging layer of macrophage communication https://t.co/gWAfEY9DEf #immunology

[Nancy Gillis 🆖☮️ @nancykgillis]

‼️📢Now available online ‼️
Evolution of clonal hematopoiesis during cancer treatment and its impact on outcomes https://t.co/L3AW8hkbgK

[Miriam Merad, MD, PhD @MiriamMerad]

Remarkable study from Irv Weissman and colleagues @StanfordMed showing that macrophage-mediated xenophagocytosis is a key barrier to interspecies chimerism and that blocking it enhances donor engraftment. (1/2)

[Journal of Experimental Medicine @JExpMed]

#Myeloid diversity in tumors: shaped by genes, location, and time. Review by Maria Nogales-Pons, Mariola Munárriz-Paños, Teresa Aceña-Gonzalo, & María Casanova-Acebes @Casanova_Acebes: https://t.co/jjWBCjZ9UX

📘 Part of JEM #Cancer Collection: https://t.co/YPWs2KQyqx
#EACR2026

[Dan Landau @landau_lab]

🤯 @CharlesSwanton

[Dan Landau @landau_lab]

Exciting breakthrough technology from the lab, now live in @CellCellPress ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!

[Ofir Cohn @CohnOfir]

Decades of research have revealed the intricacies of how dendritic cells (DCs) function, but fundamental questions remain about how this group of cells develops in humans and how this process goes awry in disease. A thread on our new work! (1/9)
https://t.co/9hgDt3r8n1

[Adith Arun @aditharun_]

Daraxonrasib results are fantastic but can we see results stratified by each G12 variant? Specifically, can we see what G12V and G12D, separately, looks like.

My hypothesis is that darax is not very good against G12D, which happens to be ~45% of mPDAC patients

[IdoAmitLab @IdoAmitLab]

The dark side of macrophages:
Macrophage plasticity is one of biology’s greatest strengths. And one of its greatest risks.
https://t.co/AmBFQHYPIr

[NEJM @NEJM]

Presented at #ASCO26:

Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: https://t.co/xwLWBZYRzq

@ASCO

[Maurizio Scaltriti @ScaltritiLab]

In 20 anni di congressi ho assistito a due standing ovation. La prima per un farmaco che ho contribuito a sviluppare. La seconda adesso.

[Science Immunology @SciImmunology]

A new Science #Immunology Review delves into the transcriptional and #epigenetic regulatory mechanisms that shape #macrophage identity and function in health and disease. https://t.co/MYOZv9Edxy

[Jordi Sarrión-Carbonell @sarrioncarbo_]

Los docentes valencianos van por su tercera semana de huelga indefinida consecutiva.

Si esto estuviera pasando en Madrid, no se hablaría de otra cosa en los medios.

[David Sancho @SanchoLab]

How does oxygen sensing shape alveolar #macrophage (AM) identity?
In our new @CellReports HIF-1α and HIF-2α play distinct, non-redundant roles in AM maturation & function
A #metabolic split that defines macrophage biology in the lung.
OPEN: https://t.co/1pxnHMUWgZ
@CNIC_CARDIO

[Jerzy Szablowski @JerzySzablowski]

qPCR allowed us to measure transcripts, but just once, destructively, and only in post-mortem tissues. Here, we show we can record transcript level history in vivo and recover this information with a blood test to make a "noninvasive qPCR". https://t.co/fe6yjsrdGr

[Eric Topol @EricTopol]

New @nature. Discovery of a new subtype of blood stem cells—HSC-iM—which have memory to previous inflammation, such as with Covid or aging, and prognostic significance
https://t.co/hRfp5xnJGj

[Jose Ramos Vivas @joseramosvivas]

🧬 Tu microbioma intestinal es una “película” dinámica que cambia a lo largo de toda la vida. 🎬
The Lancet Microbe analiza cómo la microbiota intestinal evoluciona desde el nacimiento hasta edades muy avanzadas. 👶➡️👵
Puntos clave:
✅ Evolución por etapas: aunque el microbioma tiende a estabilizarse alrededor de los 3 años, mantiene firmas microbianas distintas en infancia, adolescencia, adultez y vejez.
✅ Más que edad: también presenta ritmos diarios y fluctuaciones estacionales, influidas por dieta, hábitos y entorno.
✅ Envejecimiento saludable: en mayores de 60 años, un microbioma más parecido al de adultos jóvenes se ha asociado con menor riesgo cardiovascular y mayor longevidad.
✅ Factores externos: geografía, antibióticos, estilo de vida, genética y dieta moldean constantemente este ecosistema interno.
🔆Comprender estas variaciones temporales puede abrir nuevas oportunidades para estrategias personalizadas de salud a largo plazo. 📈
🔗👇🏻🦠 https://t.co/Ri51OkkA7G
#Microbiota #Microbioma #SaludIntestinal #Longevidad #Ciencia #Microbiología #MedicinaPersonalizada #Salud #Investigación @SEMicrobiologia