Jonathan Nelson (He/Him)

Kidney Scientist at USC. INFJ. Astrophotography Enthusiast. Vinyl lover. Neo-classical Music Apologist. @ me your favorite Sufjan song and why.

[Zhongwei Li @LiLab_Kidney]

Thank you @ScienceMagazine for highlighting our research progress in this news article.

Scientists make most authentic kidney replicas so far | Science | AAAS https://t.co/S1awdk0f6Z

[Jonathan Nelson (He/Him) @JWNdothelium]

@CterminiPhD @organizolife I was wondering if you’ve created a spreadsheet (or other system) to keep track of progress of your mentees? Something to help guide and focus 1:1 meetings and make sure tasks don’t fall through the cracks (for both mentee and mentor).

[Nature Protocols @NatureProtocols]

New Article! Expansion of human pluripotent stem cell–induced nephron progenitor cells (iNPCs) and the generation of nephron organoids from iNPCs https://t.co/skqWKgm4eW

[Afaf Saliba @Afaf_Saliba]

Excited to share that our latest study on Methylthioadenosine Phosphorylase (MTAP) inhibition in acute kidney injury has just been published at @AJPRenal !

During my PhD and postdoc in Dr. Kumar Sharma’s lab, we discovered that inhibiting MTAP offers significant protection against experimental AKI. Our findings show reduced renal injury, decreased inflammation, and preserved pathways related to proximal tubule adaptive repair post-injury.

In addition, we analyzed human single cell RNA sequencing data available from the @KPMProject, revealing that MTAP is highly expressed in kidney injury marker-positive adaptive proximal tubule cells, showing its association to key players in AKI and potential to serve as a therapeutic target for promoting kidney repair.

A huge thank you to my amazing collaborators and advisors Dr. Yidong Chen, Dr. @JWNdothelium, Abhinav Vetcha (my mentee), Wei Wei Wang, Dr. Li Kang, Dr. NAGARJUNACHARY RAGI, Dr. Soumya Maity, Dr. Hamid Rabb, Dr. Brian Reeves, and Dr. Kumar Sharma (my mentor) and the entire Center for Precision Medicine for their support @UTHealthSA @UTHSAResearch!

And stay tuned for Part 2 of this project, super exciting new discoveries are on the way!

https://t.co/CYv1BIKHgP

[Jonathan Nelson (He/Him) @JWNdothelium]

Congrats @MARIACASTABU, @GermanRick95 , @gerardo_gamba, and @dhekidney

[Gerardo Gamba @gerardo_gamba]

I am very proud to share the publication of our group by German Magaña-Ávila @GermanRick95 commanded by María Castañeda-Bueno @MARIACASTABU, showing the role of NRBP1 and TSC22D in WNK body formation and WNK4-NCC activation. Kudos María!

https://t.co/p9bKiuRiqv

[Gerardo Gamba @gerardo_gamba]

I am very proud to share the publication of our group by German Magaña-Ávila @GermanRick95 commanded by María Castañeda-Bueno @MARIACASTABU, showing the role of NRBP1 and TSC22D in WNK body formation and WNK4-NCC activation. Kudos María!

https://t.co/p9bKiuRiqv

[Jonathan Nelson (He/Him) @JWNdothelium]

@TheChungLab The Jacaranda bloom makes me feel like I’m in a Dr. Seuss storybook!

[Jess Bahena @JessBahena12]

📰 Just published in @JCI_insight
https://t.co/OL7TIX30mF
TL;DR: A new Thick Ascending Limb (TAL) cell classification shows this segment independently regulates:
🔷 Monovalent (Na⁺, K⁺)
🔶 Divalent (Ca²⁺, Mg²⁺)
👀 Fresh lens on TAL 👇

[Jonathan Nelson (He/Him) @JWNdothelium]

@Catherineoscopy Is the James Beard Award a good sign…or no? I could see it going either way.

[Jonathan Nelson (He/Him) @JWNdothelium]

@Catherineoscopy Ha…calling HEK cells “fibroblasts” is an insult to resident tissue fibroblasts 😜

[Jonathan Nelson (He/Him) @JWNdothelium]

@dr_alphalyrae https://t.co/Rbf6op8r7c

[Jonathan Nelson (He/Him) @JWNdothelium]

@Scholar_Melinda It’s so important to celebrate the submissions!

Cocktails/Mocktails with your institutional peers or cheerleaders?

[Jonathan Nelson (He/Him) @JWNdothelium]

@Catherineoscopy Reminds me when they made mice “like giraffes” (cool study with implications about blood pressure effects on the vascular).

Interesting “mammoth mice” weren’t funded by NIH…at least directly. It was a biotech company…that might have used some indirect NIH resources at UTSW.

[Jonathan Nelson (He/Him) @JWNdothelium]

@dr_alphalyrae https://t.co/HxuAZX4ZqM

[Keck School of Medicine of USC @KECKSchool_USC]

Unveiling the secrets of our body's functions, one layer at a time. Learn about wonders of multi-omics - a game-changing approach in #biotechnology. https://t.co/1UqPrbefId

[Jonathan Nelson (He/Him) @JWNdothelium]

@imyourNephBro @OHSUNephrology @dhekidney @imyourNephBro bringing the scRNAseq memes! So proud! Wish I could have been there to cheer you on!

[American Physiological Society @APSPhysiology]

Meet our opening keynote speaker for #APS2025, #NobelLaureate James Rothman! His 2013 #NobelPrize is for groundbreaking research on vesicle trafficking. Rothman will be in Baltimore to kick off the Summit on 4/24/25. Learn more: https://t.co/nNUIYaiQKG

[Keck School of Medicine of USC @KECKSchool_USC]

Study from @uscpphs found a link between between PFAS (forever chemicals) and kidney damage may be tied to dysregulation of the gut microbiome. @JesseAGoodrich @ResearchAtUSC https://t.co/rZT7Dr4cuP

[Greg Duncan @GregDuncs]

https://t.co/C2wLRnCv0m

I am excited to announce our work on how myelin loss culminates in neurodegeneration has been published at Nature Communications. While I have previously covered our findings as a preprint in more detail below, our key findings are: