Jane Lowe Meisel, MD

Medical oncologist @WinshipAtEmory specializing in treatment of and research to improve the care of patients with breast and gynecologic cancers. #bcsm #gynsm

[Jane Lowe Meisel, MD @jane_meisel]

@MPishvaian @JohnEbbenMDPhD @quirogad @TumorBoardTues @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @MammaMiaMagazin @FerMosele Probably so - and membrane permeability also playing a role. Maybe you just need a tiny bit of HER2 expression to have an effect.

[Jane Lowe Meisel, MD @jane_meisel]

@amybeumer @raffcolo @quirogad @TumorBoardTues @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @hoperugo @stolaney1 Very true, very true.

[Jane Lowe Meisel, MD @jane_meisel]

@JaniceTNBCmets @MPishvaian @quirogad @TumorBoardTues @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @sardesai_sagar @CarmenCriscit @JavierCortesMD @nlinmd I don't think we know yet - but it certainly makes sense that it could!
I think this is where trials like SERENA-6 will play a role. Also trials now looking at SERDs as first-line.

[Jane Lowe Meisel, MD @jane_meisel]

@MPishvaian @quirogad @TumorBoardTues @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @sardesai_sagar @CarmenCriscit @JavierCortesMD @nlinmd @angela_toss Good question. SERENA-6 and other trials out there (camizestrant) are in the works and will try to help answer this! So important.

[Jane Lowe Meisel, MD @jane_meisel]

@MPishvaian @quirogad @TumorBoardTues @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @MammaMiaMagazin @FerMosele I agree: probably low levels of HER2 perhaps hard to detect - but membrane permeability and other features also play a role.

[Jane Lowe Meisel, MD @jane_meisel]

@quirogad @TumorBoardTues @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @hoperugo @RimapatelMD @jsparano As long as the #research stays ahead of the disease, we can help people live well for a very long time. Exciting times ahead for sure.

[Jane Lowe Meisel, MD @jane_meisel]

@quirogad @TumorBoardTues @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @hoperugo @stolaney1 #TumorBoardTuesday @PTarantinoMD Tropion-Breast01 announcement for #ESMO23 https://t.co/lm60jkImh3

[Paolo Tarantino @PTarantinoMD]

After being announced to be positive, the TROPION-Breast01 phase 3 trial officially joins the already stellar list of abstracts planned to be presented at #ESMO23! #bcsm @myESMO

[Jane Lowe Meisel, MD @jane_meisel]

@quirogad @TumorBoardTues @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @hoperugo @stolaney1 @PTarantinoMD #hotoffthepresses
https://t.co/UbWbeMemX6

[Jane Lowe Meisel, MD @jane_meisel]

@quirogad @TumorBoardTues @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @hoperugo @stolaney1 #TumorBoardTuesday @MartaPerachino
https://t.co/IqDjUDmxpy

[Marta Perachino @MartaPerachino]

🌍TROPiCS-02🌍
HR+ mBC endocrine-R ⚠️ highly pretreated ❗️unmet need 🚦
✅OS 14·4 mo vs 11·2 mo HR 0·79 (irresp Trop-2 exp)
✅ORR Saci vs CT ➡️OR 1·63
✅TTD and QoL 4·3 mo vs 3·0 mo ➡️HR 0·75 and fatigue 2·2 mo vs 1·4 mo➡️HR 0·73
@Oncoalert #OncoalertAF

https://t.co/G4C9IlPiN4

[Jane Lowe Meisel, MD @jane_meisel]

@stage4kelly @quirogad @TumorBoardTues @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @MammaMiaMagazin @AmericanCancer @stage4kelly - very exciting!
But yes- the 💲💲considerations are so real. That's part of optimizing #communication too - we have to make sure patients feel comfortable sharing concerns about #financialtoxicity just like any other tox!

[Jane Lowe Meisel, MD @jane_meisel]

@amybeumer @stage4kelly @TumorBoardTues @quirogad @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @MammaMiaMagazin @AmericanCancer I have some patients that do IV fluids/antiemetics on day 4 and day 7 and it helps make the second two weeks of the cycle much more pleasant.

[Jane Lowe Meisel, MD @jane_meisel]

@stage4kelly @TumorBoardTues @quirogad @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @MammaMiaMagazin @AmericanCancer So true. Dose reductions, spacing out treatment, and fluids/antiemetics can help - but there's no denying it is not a walk in the park.

[Jane Lowe Meisel, MD @jane_meisel]

@JohnEbbenMDPhD @RenoHemonc @MPishvaian @quirogad @TumorBoardTues @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @sardesai_sagar @CarmenCriscit @JavierCortesMD SO challenging - though the field moving fast is a good problem to have. Makes real world data that much more important!

[Jane Lowe Meisel, MD @jane_meisel]

@esrajustesra @quirogad @amybeumer @TumorBoardTues We don't know a lot about this, because MAINTAIN was mostly ribo after palbo - but in the right patient with slow progression, it would not be unreasonable in my mind to do this and watch closely!

[Jane Lowe Meisel, MD @jane_meisel]

@MPishvaian @quirogad @TumorBoardTues @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @sardesai_sagar @CarmenCriscit @JavierCortesMD A total of 165 patients received fulvestrant, and 73 received an aromatase inhibitor - so the majority received fulvestrant but it was a mix!

[Jane Lowe Meisel, MD @jane_meisel]

@quirogad @TumorBoardTues @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @MammaMiaMagazin @AmericanCancer You can imagine there may come a time when T-Dxd could be an option for all patients, regardless of HER2 status...

[Jane Lowe Meisel, MD @jane_meisel]

@quirogad @TumorBoardTues @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @MammaMiaMagazin @AmericanCancer #TumorBoardTuesday @hoperugo #ESMO21: https://t.co/B1Fi8VV2q8

[Hope Rugo @hoperugo]

A new treatment paradigm for metastatic HER2+ BC. Nice discussion of destiny breast 04 by Shanu Modi. ⁦@OncoAlert⁩ ⁦@myESMO⁩ #esmo2021

[Jane Lowe Meisel, MD @jane_meisel]

@stage4kelly @quirogad @TumorBoardTues @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @MammaMiaMagazin @AmericanCancer So important, @stage4kelly: thank you for highlighting this!

[Jane Lowe Meisel, MD @jane_meisel]

@quirogad @TumorBoardTues @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @MammaMiaMagazin @AmericanCancer https://t.co/BYu8wCBhgt

[Jane Lowe Meisel, MD @jane_meisel]

@quirogad @TumorBoardTues @MPishvaian @JohnEbbenMDPhD @marisirico @DSoldatoMD @Erman_Akkus @FAndreMD @dradityabardia @MeganTesch @JAMouabbi @DrGattiMays @drsarahsam @JasmineSukumar @StoverLab @parikhm @hdagli @RobertoBoreaMD @FlaviaJacobs_ @z_veitch @PiotrOkupski @Dr_RShatsky @ESchattner @RMJesel @DrWGradishar @Lucarecco @JHXII_13 @nardin_simone @IlanaSchlam @elmayermd @puglisi_fabio @BianchiniGP @prarthnavb @RenoHemonc @jesusanampa @nerealiamd @DenizCanGuven1 @amybeumer @tmprowell @aftimosp @pb61 @jackel626 @4RiseUp @awolff @brunovalsi @fumikochino @stage4kelly @MammaMiaMagazin @AmericanCancer SO important. Honest conversations between patient and doctor can almost always get you to the right decision for that moment in time.