Jim Ray

Director of the Neurodegeneration Consortium at MD Anderson. Drug discovery for Alzheimer's disease is what we do. My tweets are my own views.

[Edoardo Marcora @marcora]

I am grateful to the Belfer family and the entire team at the Neurodegeneration Consortium for driving and supporting the target identification and drug discovery efforts of such an outstanding and innovative group of researchers, all united in the fight against #Alzheimers

[Jim Ray @JimRayNDC]

Blown away by the generosity and vision
Belfer family’s $20 million donation invigorates neurodegeneration research at MD Anderson https://t.co/mB4n7zJbyn

[Shane Liddelow 🍊 @LiddelowSA]

please RT

!!WE'RE HIRING!!

our growing group at @nyugrossman in #NYC is in need of a research technician (preferred) with animal (mouse and rat) expertise

read more about us and what we do here - https://t.co/tutcPz7XNz

reach out with questions (link in lab website)

[Manolis Kellis @manoliskellis]

Immensely proud to share our four papers on #SingleCell dissection of #Alzheimers Disease coming out in @CellCellPress today, reporting 2.3M #scRNA profiles and 850k #scATAC profiles across 427 post-mortem human brain samples from AD and non-AD donors in a wonderful #interdisciplinary collaboration with @DrLiHueiTsai between @MIT @MIT_Picower @MIT_CSAIL @BroadInstitute @RushUniversity
Paper 1: scRNA + vulnerability + resilience https://t.co/I7cmizyj9C
Paper 2: scATAC + GWAS + Epigenome Erosion https://t.co/bdtlu9bWDr
Paper 3: Microglia States + reprogramming https://t.co/NzEJF1wY3t
Paper 4: DNA damage + gene fusions https://t.co/hIY1tMMhLo
MIT News: https://t.co/oLDuBBb45S
Issue: https://t.co/Mup3orjhcl
News & Views: https://t.co/xQk5mepDqz

[MIT Picower Institute @MIT_Picower]

Four (!) papers in Cell today co-led by the lab of @DrLiHueiTsai offer the most detailed picture yet of the genetic and molecular underpinnings of Alzheimer’s. https://t.co/etjAnULESl @ScienceMIT @mitbrainandcog #alzheimers #neuroscience

[Gan Lab @LiGanLab]

Very excited to see that our collaborative work with @YinShenLab is out in @NatureGenet. Using a systematic approach, this study functionally characterized 308 previously unreported AD risk variants at 181 cCREs in microglia. #Genetics #ADResearch https://t.co/tfvmhJIAXf

[Alec Walker @AlecJWalker]

I’m thrilled to share the results of a phenomenal collaboration with Lasse Dissing-Olesen in the @stevens1lab. If you’re hungry for microglial biology and looking for a new set of utensils with which to dig in, please read on.

https://t.co/DcCb0rtEfN 1/n

[Shane Liddelow 🍊 @LiddelowSA]

https://t.co/o3aMgdWHdp
updated look... same data
new QoL improvements:
1. datset downloads
2. orthologs - hello swimmers & squirmers!
3. modern design, still mobile friendly

new APP coming soon - FREE for all - share your RNAseq data with only a spreadsheet and 20 minutes

[Jim Ray @JimRayNDC]

Great new paper from the macrobiologists Philip and Shane. Wow https://t.co/4RQ3wBtUgc

[Edoardo Marcora @marcora]

Lipid/lipoprotein metabolism and innate immunity/microglia are taking the stage in #Alzheimers research.

Healthy CSF Teems with Diverse Lipoproteins https://t.co/Sylicg4gEC

Lipid-Laden, Sluggish Microglia? Blame Aβ. https://t.co/TNBbwBPAAD

[Jim Ray @JimRayNDC]

Describe the feeling of watching your 18 year old give her first scientific presentation in 140 characters…

[Jim Ray @JimRayNDC]

So proud of our amazing summer student Isa Rodriguez and we’re sad to see her go! Isa is going to be a force watch out everybody…

[Edoardo Marcora @marcora]

This is also true for biomedical research and the social sciences https://t.co/Doend6gVRK

[UT MD Anderson @UTMDAnderson]

MD Anderson is again #1 in the nation for cancer care in @USNews’ “Best Hospitals” ranking: https://t.co/DpQfLjSt2G

Thanks to all who make this possible: our faculty, employees, trainees, students, volunteers, donors, advocates, partners, patients and caregivers. #BestHospitals #EndCancer

[Jim Ray @JimRayNDC]

@slavov_n Non-statistician question (don’t laugh) would it be possible to do a Monte Carlo style randomization of your data to derive a pvalue for the probability that a cluster arose by chance??

[Jim Ray @JimRayNDC]

@LasagnaLab @alzassociation @pbmartinc @PatelHenika @NurJury @EChimalJ @jmartinezbq @NeurosciStark @IUMedSchool It was an inspiring and humble talk congrats Christian and great job!

[Lasagna-Reeves Lab @LasagnaLab]

It was an honor to receive the Grundke-Iqbal Award. Thank you @alzassociation for this recognition. Grateful to work with a great team @pbmartinc @PatelHenika @NurJury @EChimalJ @jmartinezbq and thankful to be part of @NeurosciStark @IUMedSchool
https://t.co/KaNGzH6oEw

[Graham Heimberg @gheimberg]

Ever analyze a scRNAseq dataset and wonder if a specific cell state has been seen before? And if so, where in the human body? Under what conditions? Well, now you can use our lightning fast SCimilarity search and foundational model for that! ⚡️🔎🧬 https://t.co/t8L1xFOffd (1/11)

[Carmen Romero @CarmenRomM]

Learning from the best! @JimRayNDC

[Yaíma Lightfoot @YaimaLightfoot]

Back at it today! #AAIC2023 #microglia #ALZ