Jon Epstein Lab

News from Jonathan A. Epstein's lab at the University of Pennsylvania @PennMedicine. Tweets by lab members.

[karen @karenwong1013]

still don’t think I’ve fully processed the last few days but i got a PhD, isn’t that wild

so much gratitude in my heart for everyone who has been a part of the ride, and esp @jonepstein1 who shaped me into the scientist that i am today and for many years of mentorship and care

[Jon Epstein Lab @JonEpsteinLab]

And, @karenwong1013 defends on Friday!

@CAMBUpenn @pennbgs

[Jon Epstein Lab @JonEpsteinLab]

New paper out of the lab today from @karenwong1013 - we show that a subset of growth factor-responsive gene activation requires the nuclear kinase MSK2, which phosphorylates H3K9me2S10 at enhancers of these responsive genes prior to their transcription.

https://t.co/4fwLzsixX9

[Penn Medicine CSO @PennMedCSO]

Congratulations to Faith Karanja (@JonEpsteinLab/ @PennCDB) & Jeffrey Rosa (@KayserLab/ @PennPsych) on being named 2023 @LSRFdtn early-career postdoctoral researcher awardees!🎉 @PennBPP https://t.co/ocHPWEVueB

[Jon Epstein Lab @JonEpsteinLab]

Graduate student @DevBioAcademic defends his thesis 3 weeks from today! Contact him for the zoom link if you'd like to attend remotely. @CAMBUpenn

[PennCVI @PennCVI]

Great talk by Dr. Jon Epstein on In Vivo CAR T Cells for Cardiac Fibrosis during Day 2 of the Symposium! @StanfordCVI @PennMedEVDCSO @jonepstein1

[Sean M Wu, MD PhD @SeanM_Wu]

Winners of Poster Award Competition @PennCVI @stanfordcvi symposium from @Prosser_Lab @jonepstein1 and @MarguliesLab . Congratulations!!

[Margulies Lab @MarguliesLab]

Last session of the @PennCVI / @StanfordCVI symposium starting with @jonepstein1 @JonEpsteinLab

[Dr. Marisa Bartolomei @Marisa_S_B]

@aimeejuan3 epic thesis work is out--a new developmentally unveiled and allele-specific CTCF insulator & DMR regulates imprinted expression of Grb10 and Ddc isoforms in mesoderm. TY collaborators @JonEpsteinLab @DevBioAcademic
https://t.co/sq9S3EXnEJ

[Andrew Modzelewski 🧬🐁🔬 @TheModzLab]

Hey Everyone! The ModzLab has room for one more PostDoc! We have a few exciting projects that look at Retrotransposons in Development and Disease, with a bit of CRISPR sprinkled here and there. Please Re-Tweet!

Post Doctoral Researcher https://t.co/uzB11sS271

[Jon Epstein Lab @JonEpsteinLab]

We continue to explore how heterochromatin is organized at the nuclear periphery! Check out our new exciting work available on @biorxivpreprint.
PRR14 organizes H3K9me3-modifed heterochromatin at the nuclear lamina https://t.co/4wdPVlLPUk

[Hannah Billig @Hannah_Billig_]

#sciencesunday

Fighting cardiac fibrosis🔥🫀@DevBioAcademic and colleagues used mRNA containing lipid nanoparticles to generate CAR T cells in vivo, reducing fibrosis & restoring cardiac function.

Published in @ScienceMagazine
@JonEpsteinLab @YoungDgk
https://t.co/rdrodD6biW

[CAMB Graduate Group @CAMBUpenn]

Today we celebrate Ricardo Linares-Saldana from the Epstein @JonEpsteinLab @jonepstein1 and Jain labs #BGSgraduation2022 1/9

[Jon Epstein Lab @JonEpsteinLab]

Congrats to our rockstar postbac @PedroOMndezFer1 who was accepted into Penn's MD/PhD program this week, celebrating with tahini shakes from Goldie! We are soooo proud of you!!

[Ron Vagnozzi @VagnozziRJ]

Merging RNA technology and #cardioimmunology to tackle heart fibrosis - some thoughts from @McKinseyLab and us on this exciting new approach by @JonEpsteinLab & colleagues. Check out the full paper at https://t.co/CL5yb7ujWh #CardioTwitter

[Jon Epstein Lab @JonEpsteinLab]

“CAR-based therapies: opportunities for immuno-medicine beyond cancer”

Haig Aghajanian (@Haig_A), Joel Rurik (@DevBioAcademic) and @JonEpsteinLab offer their perspective on this rapidly growing area:

https://t.co/Xa2KD0rAwf

[CAMB Graduate Group @CAMBUpenn]

Our lab (and BGS/CAMB) is full of great people! @JonEpsteinLab is interested broadly in heart development. Much of our lab (including fellow DSRB student, friend, & excellent human @karenwong1013) studies how gene programs are epigenetically regulated at the nuclear periphery.

[CAMB Graduate Group @CAMBUpenn]

Good morning! I’m Joel Rurik (@DevBioAcademic) delighted to do the first CAMB twitter takeover of 2022! As a 4th yr DSRB PhD candidate in @JonEpsteinLab, I study the injured heart and develop exciting mRNA-based immuno-medicine therapies.

[Seth Thomas Scanlon @ImmunoEditor]

In this week's @ScienceMagazine cover story, @DevBioAcademic, @Haig_Ag, @WeissmanLab, Parhiz, @JonEpsteinLab, & al. use CD5-targeted lipid #nanoparticles to generate therapeutic #CARTcells in vivo!

https://t.co/H4v842s8Kq

w/ PS by Gao & Chen:

https://t.co/mOGC8NhuXA

[Eric Topol @EricTopol]

You may have missed this exciting report @ScienceMagazine for the potential of mRNA/nanoparticle -> engineer T cells to treat cardiac injury, heart failure and other fibrotic disorders
https://t.co/ioLjOgoTYY
@JonEpsteinLab @ScienceVisuals @cbickel27