Karan Kathuria

Working on cell-cell interactions in the immune system.

[Noel Johnson @noeldjohnson]

🧵1/ The half-life of a grudge. Britain crushed the 1857 revolt (Sepoy Rebellion) in northern India with mass reprisals centered on Lucknow. For decades after, districts closer to that violence vaccinated their children less against smallpox and the effect faded almost exactly as the generation that lived through 1857 died off.

[Karan Kathuria @KaranRKathuria]

Contrasting with prior work, this wonderful talk shows the dementia-protective shingles vaccine signal does not replicate in a large UK cohort.

Watch to see a thoughtful analysis of possible explanations.

https://t.co/zhylfh6wSt

[george davey smith @mendel_random]

How strong is the evidence that live shingles vaccination prevents the risk of dementia? A talk yesterday @oxprimarycare
on this available here https://t.co/08C7O9bhrR

[Matthew Taliaferro @JMTali]

New paper! How do RNAs "know" where to go inside a cell? We dug into the sequence elements that route RNAs to the right place. It turns out that, in mammals, they're surprisingly massive (>200 nt), multipartite, and wonderfully complicated. 🧵

[Daniel Dan Liu @Daniel_D_Liu]

Our new study, “Modeling glioma intratumoral heterogeneity with primary human neural stem and progenitor cells,” is online now at @stemcellreports! Spearheaded by our talented undergrad @DanTheFACSMan. A thread on the study: 1/
https://t.co/3maDQiXED9

[The Agami Lab @AgamiLab]

Please have a look to our new publication in Immunity. https://t.co/i4sNOpBN4l (@ImmunityCP )!

[Karan Kathuria @KaranRKathuria]

https://t.co/B8qFe1BrL1

[Karan Kathuria @KaranRKathuria]

Generation of public neoantigens by tumor exposure to IFNg -> tryptophan shortage -> ribosomal frameshifts that make W>F mutations. Cool result from proteomics by @AgamiLab!
What other co-translational mods impact anti-tumor T cell responses?
🔗Link below ->

[Karan Kathuria @KaranRKathuria]

Beautiful work from @DjenetBousbaine and @mfgrp characterizing the immune response to a human skin commensal and its utility as a vaccination platform.

Remarkable antibody response kinetics worthy of an entirely new study.

[Michael Fischbach @mfgrp]

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55

[Karan Kathuria @KaranRKathuria]

A motivating excerpt:
"Creativity comes from hard work. You have to be able to completely devote yourself to the task. When you do so, then your subconscious mind is starved from thinking about anything except the problem."

Happy reading: https://t.co/VhmCwKIaTb

[Karan Kathuria @KaranRKathuria]

Enjoyed this weekend's reading - an interview with @Eric_Betzig. Had fun learning about the beginnings of super-resolution, his consistency in trying out new ideas, and the shift from analyzing biological snapshots to continuously imaging these dynamic processes. 1/2

[Karan Kathuria @KaranRKathuria]

Kazuki is an excellent scientist and a kind person. He has a new perspective on how to study the intersection of our microbiome & immunity. This is a great (and early) opportunity to join a lab that’s sure to enrich our understanding of this important field in the coming years.

[Kazuki Nagashima @MicrobiomeTcell]

The Nagashima lab @MCB_Harvard seeks an ambitious postdoc in immunology, microbiome and diet. Apply here👇 if you want to work on T cell biology in an incredible environment. https://t.co/Djf9C44kEI
@Harvard #immunology #microbiome #postdoc

[Mohammad S. Esfahani @mohamshah]

I'm seeking a computational postdoc for my team @StanfordRadOnc! We're building ML tools to crack genomic data for enhancing early cancer detection (and more). Join us!🧬💻 Please RT!
https://t.co/gAkkBKZJzh

[Karan Kathuria @KaranRKathuria]

A significant advance in solving the TCR-antigen prediction problem that demonstrates the power of improving data quality/quantity and models in parallel. The generative model in Fig. 7 is a peek into the future of this field. Incredible work by Binbin, Ethan, and Manjima!

[Binbin Chen @DrBinSquared]

Excited to share our work on TAPIR, a generalizable ML model that can predict TCR-target interaction!

T-cell receptors (TCRs) are involved in most diseases, but linking their sequences with targets is an unsolved grand challenge in the field.

https://t.co/TYLO873Flx

[Daniel Dan Liu @Daniel_D_Liu]

Excited to share my PhD work, out today in @CellCellPress! Thankful for a great team and my mentor Irv Weissman. A rundown of the study: "Purification and characterization of human neural stem and progenitor cells." 1/
https://t.co/KTKIoNDQGw

[Vamsee_Mallajosyula @VMallajosyula]

Excited to share our work on antigen-specific #tcell responses post #mRNA #COVID19 #vaccine using the new #spheromer technology!
Out now in @ImmunityCP @Jodi___G
https://t.co/42AhFf2HRB (1/n)

[Wei Luo @luoweicool]

Great experience collaborating with an amazing bioengineer @QianY20878657. Putting a TLR7 agonist in special nanoparticles can change the quality of GC response, leading to the generation of antibodies targeting subdominant epitopes (e.g stem of HA).

https://t.co/SYrpSqb6OM

[Ash Alizadeh, MD/PhD 🇺🇸 @AshAlizadeh]

Very excited to share our new study on determinants of resistance to anti-CD19 CAR T-cells (CART19) in large B-cell lymphomas (LBCLs)! Out today in @Cancer_Cell /1

https://t.co/1Dw9GbIEN0

[Jiefu Li @JiefuBiol]

We are hiring @HHMIJanelia!
systems cell surface biology, neuro, immune, method development...
https://t.co/6dSbsB1uiQ

[Tobias Lanz @TobiasLanz]

Very happy to see our study in print @NatImmunol today! BNT162b2 vaccine induces divergent B cell responses to SARS-CoV-2 S1 and S2. https://t.co/V8cYkbk7tx

[King L Hung @kinglhung]

Our paper is out in @Nature! Extrachromosomal DNA molecules huddle together in cancer cells to activate oncogene expression (which we call ecDNA hubs). A great collaboration with @KatieEYost, @HowardYChang, @549nm, Zhe Liu, and others. (1/10) https://t.co/FGMYDEfUmx