David J Klein

AI technologist and neuroscientist, intelligent products for interfaces, brain health, biodiversity, and clean energy

[David J Klein @Kleinspaces]

Real world bottlenecks. Remember the 2016 'DNA sequencing soars' chart? With the same generous metric (WGS+WES, sample-level), 2025 seems to land at ~3–4M genomes, far below the 100M from 18-mo doubling (the slowest curve). Real doubling appears to happening every ~6 yrs not 1.5.

[David J Klein @Kleinspaces]

“As predicted by proponents of symbolic cognitive architectures, LLMs adopt representations that are structured and modular, both in activation and in weights space”

[David J Klein @Kleinspaces]

Ellie Pavlick keynote #CCN2025 @Brown_NLP
Emergent compositionality in LLMs

[David J Klein @Kleinspaces]

Ellie Pavlick keynote #CCN2025 @Brown_NLP
Emergent compositionality in LLMs

[Roy E. Bahat @roybahat]

Yes, we are actively investing. In fact, today we announced @bloombergbeta has a new fund to invest – our fifth.

Startups keep evolving, faster than ever, and we know the best way we can support them is by staying steady, a constant on which they can depend. So our new fund is the same as the previous ones.

---

Though it’s our first new fund in a world after generative AI, vibe coding is everywhere, engineers keep getting faster thanks to that AI, and AI startups hit revenue records all the time...

We're doing what we've always done.

We still…
> Want to serve extraordinary founders who define the future of work.
> Put #foundersfirst.
> Invest as early as day zero, and as late as our up-to-$1M-or-so first checks allow (i.e., pre-seed and seed).
> Define the "future of work" to extend beyond productivity tools, to how work can serve everyone.
> Commit to making the startup world welcome to people of all backgrounds.
> Invest from a $75M fund.

Our three equal investing partners: @karinklein (who continues to run the "Acela corridor"), @jamescham, and me. (Well, we did recognize that @AngKMartin is a partner -- because we need operations to be great as investors.)

Modeled on Bloomberg LP, we still aspire to be the most transparent investors. And we're here whether the market goes up or down.

None of that has changed. Same as 2022, same as 2019, 2016, 2013.

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What’s different is… well… we’ve got more evidence we’re right where we like to be:
> 93 founders we’ve backed have become millionaires — and 24 of those have made $10M or more
> Founders we’ve backed have gone on to raise more than $10B
> 10 startups we’ve backed are worth more than $1B (Flexport, Replit, MasterClass to name a few!)
> Startups we back outperform — worth $24M more at next round

We’ve backed extraordinary founders like @Replit’s @amasad and @HayaOdeh and @Flexport’s @typesfast, where we were the first VC to say yes to both companies, along with companies like @AirspaceIntel, @CampusGrad, @MadeWithCapsule, @LambdaAPI, @LaunchDarkly, @MasterClass, @Netlify, @ShieldAITech, @weights_biases (just acquired by @Coreweave), and more.

We’ve also been busy since last time, but since X (in which we are small shareholders after they acquired Laskie) may penalize me for links, I won't tell you that here :) Go look at the one named after a color and what's in the air for that one.

Our firm is more than our partners and today, our team includes @AngKMartin, @loriberenberg, @amytam01, @KB2o22, @moraaonyonka (and assists from @megmbolger!).

We of course remain close with those who have worked on our team, including @shivon @strickland_dan @theamberyang @minney_cat @harleysugarman @sydneyjtiedt @lisawehden @ShainaConners @morganpolotan @cody_mccauley among others!

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And we’re forever grateful to @MikeBloomberg, a founder backing us so we can back more founders. Cycles continue!

We want to be the first text for early-stage companies, partners through your journey, working with winners.

If you know a founder who’s a great fit for us, please share this! "Yes, we're actively investing."

[David J Klein @Kleinspaces]

@Miles_Brundage Sometimes bad is bad

[David J Klein @Kleinspaces]

https://t.co/lBTaATr1wJ

[David J Klein @Kleinspaces]

😅

[David J Klein @Kleinspaces]

@KordingLab @CIFAR_News Doctor Cifarious ⚡️

[David J Klein @Kleinspaces]

Preach Stevie
https://t.co/4pWbAbp8dq

[Christopher Rozell @crozSciTech]

Excited that Georgia Tech just got final approval for a new and unique interdisciplinary PhD program in "Neuroscience and Neurotechnology". Looking forward to advancing research, innovation and workforce development for next gen brain science and health.

https://t.co/WS5vsgzAZ7

[David J Klein @Kleinspaces]

@mark_riedl It's come a long way

[David J Klein @Kleinspaces]

@crozSciTech @BWJones +1 on Covid observation

[Shivon Zilis @shivon]

Let’s not forget that there’s this one cute little fleet of *millions* of terrestrial robots out navigating the world and collecting visual inputs on the daily… and rumor has it that their bipedal robot friends will join their explorations soon. 😇

[David J Klein @Kleinspaces]

How long there really is left in a software update is one of the remaining grand challenges of science.

[David J Klein @Kleinspaces]

@crozSciTech 🎉going today!

[David J Klein @Kleinspaces]

Thank you Los Altos.

When I started having success developing AI for biodiversity conservation, government policy was the missing piece for me.

I learned a lot. Overall it was very humbling. I might have done a little good.

[Kording Lab 🦖 @KordingLab]

Georgia Tech is hiring in Bioengineering with a focus on neuroscience. Should be interesting for a lot of people in the broad Neuro/engineering/tech/society space. https://t.co/KfgKo5k72a (background here: https://t.co/xk2O52RUAF)

[David J Klein @Kleinspaces]

How do I close this

[Christopher Rozell @crozSciTech]

Excited to share this paper using new neurotech and explainable AI to advance DBS for treatment resistant #depression (TRD). Team effort including @HelenMaybergMD, @sankar_alagapan and Patricio Riva-Posse. Summary thread!

https://t.co/7REq1gasDQ
@nature

PC: Mike Halerz