Kuvera Sikhakhane, MD 🍁

FM physician. Husband. South African/Canadian. Based in Oregon.

[George Galloway @georgegalloway]

The Butcher of Kyiv in her own words

[George Galloway @georgegalloway]

The EU is funding this

[Kim Dotcom @KimDotcom]

This is the heartfelt video message sent by Vladimir Putin to the American people after 9/11. Actions followed words and Russia helped the US to fight international terrorism. The US Govt thanked Russia by staging a coup in Ukraine to start a proxy war.

[Max Blumenthal @MaxBlumenthal]

Middle aged Ukrainian men chained and shipped to the front so Beltway neocons can have another "year of offense"

[Aleksey The Great 🇷🇺🎖 @aleksthgrt]

Ukraine is the only country in the world where soldiers are sent to war with their hands handcuffed. Why ? Because they are ruled by a terrorist regime.

[Kelly Haughton, MD @kidneydoctorpa]

AKI guidelines hadn’t been updated since 2012.
The KDIGO 2026 AKI/AKD Public Review Draft just dropped and it changes how we define, diagnose, and follow up after acute kidney injury.
Here’s what every nephrologist, intensivist, and internist needs to know 🧵
⚠️ Public review draft only · Not yet final guidelines

[Kuvera Sikhakhane, MD 🍁 @KuveraSiK]

@drabdulhameed07 B

[Laura Vater, MD, MPH @doclauravater]

In med school, I learned that Huntington's disease was one of the most devastating inherited conditions. It caused progressive neurological decline, starting around age 30. There was no treatment. Now, Huntington's has been treated for first time.

This is why we fund science.

[Muthu Vaduganathan @mvaduganathan]

2025 HF RCT Landscape 💊💉

HFpEF
GLP1/GIP: #MARITIME
sMRA: #SPIRRIT #SPIRITHF
nsMRA: #REDEFINE
ASi: #EASiHFPreserved
IL6i: #HERMES

HFrEF
nsMRA: #FINALITY
ASi: #EASiHFReduced
Myosin Activator: #COMET
Dig: #DECISION
IV Fe: #ICONICHF

All LVEF
nsMRA: #CONFIRMATION
MRmod: #BalanceD

[Kuvera Sikhakhane, MD 🍁 @KuveraSiK]

Unpopular opinion, but govt health ministers should be Physicians. There is no other substitute.

[Kuvera Sikhakhane, MD 🍁 @KuveraSiK]

@DrRajeshG1 Pericardial cyst

[Neil Stone @DrNeilStone]

Robert F Kennedy Jr is an anti vaxxer

He's against all vaccines

Always has been

Always will be

Which makes him an

anti vaxxer

[Kuvera Sikhakhane, MD 🍁 @KuveraSiK]

I feel like this is the most commonly shared image of pedal edema seen by all in medical training.

[CardiovascularCorner @TrackYourHeart]

Which drug will be beneficial for this patient if he is diabetic and hypertensive presented with pedal edema and breathlessness on exersion?

[Prof Omid Khaiyat M.D., PhD @Omid_HopeUni]

Sarcopenia👇🏼

✅ Resistance training 👉🏼effective strategy for treatment & prevention
✅ Aerobic exercise may boost effects of resistance training
✅ Combined nutritional & exercise👉🏼may enhance effectiveness beyond exercise alone

https://t.co/pL83WQkTP0

#sarcopenia #ageing

[Kuvera Sikhakhane, MD 🍁 @KuveraSiK]

@Doctors_GUILD @grok what's the dx?

[CKJ @CKJsocial]

Empagliflozin and fluid balance:

Results from the SiRENA project

https://t.co/obk667uAZg

[Prof Omid Khaiyat M.D., PhD @Omid_HopeUni]

Physiology of sedentary behavior👇🏼

#exercise #health #muscle

https://t.co/JLCF7ewqn6

[NEJM @NEJM]

Recent meta-analyses showed that metabolic dysfunction–associated fatty liver disease (MAFLD) is associated with an increased risk of new-onset heart failure, atrial fibrillation, chronic kidney disease (CKD), and certain extrahepatic cancers, increasing the risk of each by a factor of 1.2 to 1.5. The figure shows the relation and strength of associations between MASLD and the incidence of major adverse liver outcomes, fatal and nonfatal cardiovascular events, atrial fibrillation, type 2 diabetes, CKD, and certain extrahepatic cancers (especially extrahepatic gastrointestinal cancers).

Learn more in the Review Article “Metabolic Dysfunction–Associated Steatotic Liver Disease” by Giovanni Targher, MD, Luca Valenti, MD (@lucavalenti75), and Christopher D. Byrne, MB, ChB: https://t.co/EJhFlIcXOp

[TheLiverDoc™ @theliverdoc]

There are now two approved drugs in the world for the severest form of non-alcohol-related fatty liver disease (steatohepatitis/ now known as metabolic-dysfunction associated steatohepatitis or MASH)

1. Resmetirom (Rezdiffra)
2. Semaglutide (Ozempic)

These are based on Category A level evidence.

There are NO other drugs with this level of evidence for doctors to prescribe for severe NASH (severe form of fatty liver disease).

Vitamin E and Omega-3 only reduces liver fat & inflammation modestly, they do not affect fibrosis (liver scarring) which is most important.

Utterly useless drugs for severe fatty liver disease include:

Ursodeoxycholic acid (UDCA, Ursodiol), milk thistle or silymarin, saroglitazar, S-adenosyl methionine (SAMe)

Make no mistake, the primary treatment for severe form of fatty liver disease is treatment of metabolic disease (diabetes, low functioning thyroid, obesity, high blood pressure, high lipids) and aerobic exercise + weight training and daily calorie deficit.

[Ahmed Bennis MD 🫀 @drbennisahmed]

Transferrin Saturation Is a Better Predictor Than Ferritin of Metabolic and Hemodynamic Exercise Responses in HFpEF

In patients with HFpEF, Tsat%, but not ferritin levels, relates to more favorable overall metabolic and hemodynamic responses to exercise and better outcomes.
@mvaduganathan @gcfmd @SJGreene_md @AndrewJSauer @ankeetbhatt @dranulala @BiykemB @DrMarthaGulati @hvanspall @hfcollaboratory @CMichaelGibson @ShelleyZieroth

https://t.co/qGaUzKg4IM