LDCruz-Zaragoza

A biochemist with an interest in the interception where chemical entities organize and become biology. Postdoc researcher specialized in organelle biogenesis.

[LDCruz-Zaragoza @LDCruz10]

@RyanLab_MBU @tcdTBSI @tcddublin Congrats @RyanLab_MBU

[Cell Biology J-Club @cell_club]

Silencing mitochondrial gene expression in living cells | Science https://t.co/3MDGBybCfV

[RehlingLab @RehlingLab]

Silencing mitochondrial gene expression in living cells | Science https://t.co/wRDoCKbFzT - Now available in new Science issue. Thanks again to all colleagues for a wonderful collaboration. Awesome work of LD Cruz-Zaragoza!

[Hana Antonicka @HAntonicka]

A great collaboration between clinical and research teams to describe mutations in FASTKD5 in patients with Leigh syndrome. Thank you all!

[LDCruz-Zaragoza @LDCruz10]

Interesting tool @MickLab . Nice work!

[Mick lab @MickLab]

Proud to share our work by a fantastic team, spear-headed by PhD student @Kainerox with major contributions by #xenopus expert @RosiFeistel.

We developed an improved iAPEX-based #ProximityLabeling method for #massspec based subcellular #proteomics.

https://t.co/0jDlrlkK7M

[Dimova Lab now at @DimovaLab.bsky.social @DimovaLab]

Still looking 👀 for a suitable candidate. Please retweet

[LDCruz-Zaragoza @LDCruz10]

Thanks to all that helped at the bench: Mirjam Breuer, Dairovys Anner Jimenez Fundora, and Oliver Urbach

[LDCruz-Zaragoza @LDCruz10]

Thrilled to see our publication online! Big thanks to all authors, collaborators, and all who contributed to this work. @RehlingLab, Henning Urlaub, @RizzoliSilvio, @RDennerlein_Lab, @DavidPacheu
🎉https://t.co/oNnX08ffZW

[LDCruz-Zaragoza @LDCruz10]

Saying goodbye to a successful 2024, and looking forward to the New Year 2025! 🎉

[LDCruz-Zaragoza @LDCruz10]

Great work by the Schuldiner's lab!

[Journal of Cell Biology @JCellBiol]

A proteome-wide yeast degron collection for the dynamic study of protein function. New tool developed by Rosario Valenti, Yotam David, Maya Schuldiner and colleagues @WeizmannScience: https://t.co/4MQzXDLfjA

#CellCycle #CellDivision #Technology #CellMetabolism

[Aging Science News @AgingBiology]

Aged neurons don’t register energy need
https://t.co/SZwnQTrzXT

[LDCruz-Zaragoza @LDCruz10]

Impressive work

[Alice Ting @aliceyting]

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from transgene expression and real-time fluorescence to modulation of innate cell behavior (excitation or inhibition of neurons, induction of cell migration, etc.)?

Today we report in Nature a new technology platform that provides a step in that direction: PAGERs, for Programmable Antigen-gated G protein-coupled Engineered Receptors, convert recognition of extracellular soluble or cell-attached antigens into diverse user-selected responses. PAGERs are based on G-protein coupled receptors (GPCRs), which themselves are not structurally modular, but we were able to build in modular antigen gating by fusing an antagonist peptide to the extracellular N-terminal end, and then gating the antagonist with a fused antigen-binding nanobody.  When antigen binds, it sterically interferes with the antagonist, leading to relief of receptor inhibition. Drug or agonist can then turn on PAGER.

https://t.co/Clt8yjyk2y

[LDCruz-Zaragoza @LDCruz10]

A fantastic opportunity to advance mitochondrial research with Anna @WredenbergLab!

[WredenbergLab @WredenbergLab]

We have 1-2 PostDoc positions for enthusiastic researchers interested in mitochondrial biology. Apply here. #mitochondria #mitojobs
https://t.co/tOv2e05PHF

[Oscar Vargas Rodriguez @OSENVARO]

Perfect timing! our latest paper on #tRNA engineering is now published, coinciding with the ongoing #tRNA2024 conference. This publication is the result of a phenomenal team effort with @jeffery_tharp

https://t.co/2vMYCPvFrZ

[LDCruz-Zaragoza @LDCruz10]

Congrats!

[Edel Pérez-López @Edel_PLopez]

Honoré de rejoindre le comité scientifique consultatif du @FRQ_NT ! Hâte de contribuer à l’excellence en recherche, à l’interdisciplinarité et à l’innovation durable au Québec 👏 - @universitelaval

https://t.co/OIIpCIuuAy

[Edel Pérez-López @Edel_PLopez]

Honoré de rejoindre le comité scientifique consultatif du @FRQ_NT ! Hâte de contribuer à l’excellence en recherche, à l’interdisciplinarité et à l’innovation durable au Québec 👏 - @universitelaval

https://t.co/OIIpCIuuAy

[LDCruz-Zaragoza @LDCruz10]

@OdedRechavi Adding the functional relevance to the manuscript's last figure 😂

[Johannes Herrmann @Herrmann_lab]

There is still the chance to register for the webinar with Nils Wiedemann, Agnieszka Chacinska, Toni Barrientos, Jan Riemer and myself next Tuesday! 250 mitochondria lovers already signed up! @Riemerlab @A_Chacinska @Antonio41949078 @Mito_News

[LDCruz-Zaragoza @LDCruz10]

@Edel_PLopez @moniquejrivera @kelseytobin_ Socio, y la dieta? 😂

[LDCruz-Zaragoza @LDCruz10]

@OdedRechavi Or the used tip in the Kit's buffer.