What does pseudouridine (ψ) actually do to protein production? It’s been studied for years — but its impact on translation has remained surprisingly unclear.
We were excited to tackle this directly in our latest NAR paper: https://t.co/wyHTH4Y9ps
Years in the making: a detailed aging gene signature in mice and rats. >30 tissues, high Ns, multi-time points throughout the lifespan. >5000 samples in total. The data is accessible, so you check to see if your favorite gene is age-regulated.
https://t.co/5heN6ixvt1
ERC-funded positions now open❗️❕❗️
Join the @GiuntaLab to understand human DNA evolution through the study of satellite repeats 🧬🧫🔬
APPLY here:
https://t.co/8cUYCV8YET
Pls RT 🔄🗨️🙏
The David Sinclair (@davidasinclair) $720,000,000 Resveratrol Train Wreck
Video shoutouts:
- Prof. Matt Kaeberlein (@mkaeberlein)
- Prof. Brian Kennedy (@BKennedy_aging)
- Dr. Peter Attia (@PeterAttiaMD)
- Prof. Richard Miller
- Prof. Jeffery Flier (@jflier)
Excited to share this work exploring the profile of senolytic CAR T cells in physiological aging. Great collaboration with Inés Fernández-Maestre, that started @MSKCC and bore fruit @amor_lab@CSHL
https://t.co/syjiHEaQmw
Very saddened to hear of Judy’s passing. I had the incredible opportunity to collaborate with Judy during my PhD. Judy was nothing short of an extraordinary scientist that shaped the field of aging & senescence to be what it is today. A true pioneer and champion in science.
I'm deeply saddened to share that we have lost a remarkable friend, a wonderful mentor and esteemed colleague, Judith Campisi. Judith's impact on those around her was profound and lasting. Her legacy will continue to inspire us all. Rest in peace, Judy. You will be greatly missed
A reminder that the abundance of 'house keeping' proteins varies significantly across cells and tissues.
GAPDH (glyceraldehyde-3-phosphate
dehydrogenase) is often slandered a 'house keeping' protein, and its abundance varies significantly across human tissues.
Writing a manuscript (or two 😉) from pure scratch after a few years… needless to say I’ve taken quite a few walks around the lab and campus to ummm… think (procrastinate).
Anyways, stay tuned 📊📈💻
Check out our latest review | LINE-1 retrotransposition and its deregulation in cancers: implications for therapeutic opportunities by @CarlosMendezPhD.
Our thanks to @GenesDev.
https://t.co/AvA0taf9Wf
@NYCMayorsOffice@NYCMayor Now go after Stonehenge NYC, notoriously gouging tenants and leaving large swaths of apts open in their buildings to drive prices higher.
🐭🧬Our paper on locus-specific mouse L1 activity and regulation, led by the indomitable @Patricia_Grds is out @genomeresearch!🧬🐭
This study evolved from a simple question: what defines the mutagenic potential of a new L1 copy in vivo?
https://t.co/Xoa7FGh1rJ
A thread:
1/n