Marcela Moncada-Velez

Scientist @CasanovaLab working in human genetics, immunology and molecular biology of primary immunodeficiencies (PID)

[Marcela Moncada-Velez @Marce_MoncadaV]

Thrilled to share our new @JExpMed paper: Autoantibodies against type I IFN were the hidden killer in the first US H5N1 fatality (a 71-year-old man from Louisiana). Turns out the deadliest part of bird flu can be our own immune system going rogue. https://t.co/CFDTLDLmG5

[Casanova Lab @casanova_lab]

1/ A year ago, a 71-year-old Louisiana man died from H5N1, marking the first avian flu death in the US. Now we report in @JExpMed that the cause of his death is rogue autoantibodies neutralizing type I IFN (AutoAb-IFN). https://t.co/L3COz2taJR

[Marcela Moncada-Velez @Marce_MoncadaV]

@MBarricarteLab @VUMC_VCI @JanetMarkle Y la estudiante más pequeña a cual laboratorio pertenece ? Está hermosa 🤩

[Marcela Moncada-Velez @Marce_MoncadaV]

@alexyema @casanova_lab @vanessabryantoz @SatoshiOkada3 @BogunovicLab @prandocarolina @XiaofeiKong1 @BoissonDupuis Great picture, nice to see you together…and yes, great memories from Myco group 😃!!!

[Alexandre Bolze @alexbolze]

What is the cause of RARE cases of myocarditis following COVID-19 mRNA vaccination?

Read our hypothesis & our plan to answer the Q: https://t.co/ta841zMoqT

Thankful to work with a great team of scientists & physicians from all over the world.

Details in 🧵

[Marcela Moncada-Velez @Marce_MoncadaV]

@JExpMed @MasatoOgishi @ryangrui @BoissonDupuis @casanova_lab @RockefellerUniv @AriasAAS

[Casanova Lab @casanova_lab]

1/ Free registration is still open for this week's 29th Annual Henry Kunkel Society virtual meeting on "Innate Immunity: from basic biology to human disease" chaired by @BogunovicLab of @IcahnMountSinai, and in partnership with
@JExpMed! Register here: https://t.co/JkuIgeprAv

[Rockefeller University @RockefellerUniv]

Paul Bastard of the @casanova_lab and @Inserm has won the @MichelsonPhils & @ScienceMagazine Prize for Immunology for revealing factors that underlie varied susceptibilities to #COVID19. Congratulations!

Learn more about his work here: https://t.co/FaNi8yVLrW

[Marcela Moncada-Velez @Marce_MoncadaV]

Great review!!!

[Casanova Lab @casanova_lab]

1/ Here is a review in @Nature by the https://t.co/vuxFKEuYEs of the human #genetic and immunological determinants of life-threatening #COVID-19 (https://t.co/LsIIRmZPdb).

[Marcela Moncada-Velez @Marce_MoncadaV]

Congratulations Jean-Laurent @casanova_lab, very well deserved!!!!

[The Abarca Prize @AbarcaPrize]

📣 Prof. Jean-Laurent Casanova (@casanova_lab), researcher at @RockefellerUniv, has been chosen as winner of the @AbarcaPrize for his study of #infectiousdiseases, including Covid-19, and for solving the “infection enigma”.

Details of the statement: ⬇
https://t.co/ObUU8v45OH

[Marcela Moncada-Velez @Marce_MoncadaV]

Second great research from our group with the help of many scientists, physicians and patients!!!

[Casanova Lab @casanova_lab]

1/ In this 2nd @SciImmunology paper (https://t.co/EMZrAkMNM1), we show pre-existing auto-Abs neutralizing low physiological concentrations of type I IFNs account for 15% of critical COVID-19 cases, including 20% of critical cases in patients >80 yrs and 20% of deaths across ages.

[Marcela Moncada-Velez @Marce_MoncadaV]

Happy and honored to be part of this great research!!! Huge effort not only of people like me were doing experiments but also from physicians and patients around the world.

[Casanova Lab @casanova_lab]

1/ In this first @SciImmunology paper (https://t.co/1uTHUO7w9c), we show that at least 1% of men younger than 60 years with life-threatening COVID-19 are sick because of X-linked recessive (XR) TLR7 deficiency.

[Marcela Moncada-Velez @Marce_MoncadaV]

@ALNeehus @casanova_lab @JExpMed Great work Anna-Lena, congratulation to you and the team!!!

[Anna-Lena Neehus @ALNeehus]

Happy to share my first PhD paper investigating the mechanism by which human PKCD deficiency underlies susceptibility to infectious disease. Published today in @JExpMed https://t.co/byf9TIO3u8 @casanova_lab

[Bustamante Jacinta @BustamanteJaci1]

Genetic, Immunological, and Clinical Features of 32 Patients with Autosomal Recessive STAT1 Deficiency https://t.co/R6Jl2rxiFE

[Bustamante Jacinta @BustamanteJaci1]

Congratulations to Tom Le Voyer for his important contribution in the first international cohort of patients with autosomal recessive STAT1 deficiency. Thanks so much to all collaborators in the world. https://t.co/R6Jl2rxiFE

[Shen-Ying Zhang @ShenYingZhang1]

Officially published too! Again, TLR3, type I IFN, and the central nervous system. :)

[Bustamante Jacinta @BustamanteJaci1]

Our new work about Gata2 defiency & mycobacterial infectious diseases is online at J Clin Imm
https://t.co/v7R44rlrEa
Excellent international collaboration with many friends in the world.

[Marcela Moncada-Velez @Marce_MoncadaV]

Now Live:
https://t.co/4WbAlalnmN

[Marcela Moncada-Velez @Marce_MoncadaV]

No se lo pierdan/ don’t miss it !!!
@casanova_lab @GIDPudea @AriasAAS

[Universidad de Antioquia @UdeA]

🦠 Te esperamos en una sesión más del Foro Reflexiones #COVID19.
—Hablaremos sobre "Inmunidad de interferón (IFN) tipo I deteriorada en pacientes con COVID-19 potencialmente mortal" con el Dr. Jean-Laurent Casanova y el Dr. José Luis Franco.

🔴 https://t.co/SuuO1N4vfI

[Rockefeller University @RockefellerUniv]

Just how sick we get from #COVID19 depends on genetic variations, including ones that sabotage immune molecules called interferons. Check out this @KnowableMag piece from @timvernimmen on the @casanova_lab's work to better understand why: https://t.co/xECSXQZFok