Excited to share our latest #PrePrint 🎉
https://t.co/vtiC8nslsO...
We wanted to understand how epithelial cell-fibroblast crosstalk is distinct in #PancreaticCancer and #Pancreatitis. This took us on a (long...) journey...have a read! Congrats to Wenlong and Munta. 💜
Going from biotech to tech was an unexpectedly humbling experience, almost an egodeath. In biotech, doing bioinformatics during a PhD or postdoc is considered highly technical, you’re the “computer person” in a world of wet-lab scientists. But in tech, that experience doesn’t carry the same weight. If you haven’t trained a billion-parameter model or built a platform from scratch, you’re not seen as “technical” enough. The shift kinda forces you to rethink what being “technical” really means. Or perhaps we're in this bay area bubble of accusing each other of not being 'technical enough' till death takes us.
We are seeking an experienced Bioinformatician to lead data analysis for a new research group.
If you have a passion for working with large-scale genomics datasets and a deep understanding of biological principles, please apply.
https://t.co/BfaS4EAucw
Uh oh: deep learning models in genomics lose badly to very simple linear models. Could they have been over-hyped? (new paper by @s_anders_m@const_ae and Wolfgang Huber) https://t.co/NerMDHCMzv
For biological data, if you don't have deep expertise in this low value work called data cleaning, u r lacking a fundamental understanding of the idiosyncrasies of the data. Without this knowledge, it is impossible to seriously model data.
🎉Huge congratulations to @Debi_Mukh@BiffiGiulia Group @CRUK_CI for being awarded the @MSCActions Postdoctoral Fellowship! She will explore how cancer-associated fibroblasts (CAFs) contribute to #Cachexia in #PancreaticCancer.
Read more👉https://t.co/O7S33iaZZq
🎉 Scanpy 1.11.0 is out! 🎉 just after reaching 2000 stars on GitHub!
- sc.pp.sample replaces subsample with many new features
- Sparse Dask support pca
- session-info2 package for more reproducible notebooks
See the release notes: https://t.co/jRDHHlf9kX
A review to get you talking! 💬
@Pris_Cheng, Marta Zaccaria, and Dr. @BiffiGiulia discuss recently identified functional interactions of #CAF subtypes with immune cells, and other stromal cells in primary tumors and metastases. @CRUK_CI
📚 https://t.co/KwwYO0pyZf
A really comprehensive fibroblast review in primary and metastatic cancers! In @trendscancer from @BiffiGiulia@marta_zaccaria_@Pris_Cheng
Wonderful job!
Illustrations below highlighting
(A) Cues that contribute to fibroblast heterogeneity in cancer
(B) Fibroblast Cancer cell crosstalk
(C) Fibroblast Immune cell crosstalk
(D) Fibroblast Stromal cell crosstalk
Link to manuscript below.
@CR_UK@CRUKresearch
Do you have experience analyzing scRNA-seq and an interest in working with (extremely) lovely people to help analyze their data? Come and join us then ...
🚨We are 👀 for our next #Bioinformagician🚨
Do you have (preferably lots of) hands-on experience with single-cell/single-nuclei RNA-sequencing? Want to analyze our lab’s pancreatic cancer (and more) datasets?
Join us @CRUK_CI!
Please RT 👇🏼 https://t.co/jJnIYaHMXG