Nan Xu

PhD student @studerl lab | @GSKGradSchool

[Developmental Cell @Dev_Cell]

Online now: Environmental and genetic risk factors of depression converge on neuronal dysfunction driven by changes in cholesterol homeostasis https://t.co/sRiwOOYc68

[Lydia Finley @lydfinley]

Things I wish more people knew about doing science in the US (thread):

[Arianna Baggiolini @BaggioliniA]

📢📢📢How can we obtain a robust outer radial glia (oRG) population in 🧠organoids from guided differentiation? Exogenous LIF does the trick.
Our new paper shows that cortical pericytes are among the cell types secreting LIF. Adding pericytes to cortical organoids recapitulates oRG emergence, highlighting the importance of the microenvironment in shaping the diversity and differentiation of neural progenitor cells.

[Gabriele Ciceri @gabriele_ciceri]

Excited to share that our paper on an epigenetic barrier setting timing of maturation in human neurons is finally out @Nature! https://t.co/uTfZXiEJki.

[Lorenz @studerl]

Excited to share initial press release @BlueRockTx on promising results of Phase 1 trial in 12 PD patients https://t.co/zWrWIVjE78. A major milestone on a 20+ year journey. Amazing leadership by @TabarViviane, @MSKCancerCenter & @BlueRockTx (@bigosi, Mark Tomishima & many more).

[Science Magazine @ScienceMagazine]

The @ZoonomiaProject’s sequencing of more than 240 mammal genomes is paving new roads for understanding mammalian diversity and evolution and ourselves.

Learn more in a new special issue of Science: https://t.co/s4N159JW7o #Zoonomia

[James Briscoe @briscoejames]

Fascinating results from @mwdorr & co & nice use of scRNAseq

Increased temperature accelerates development of different zebrafish cell types by different amounts

Cell types with high protein expression demand more sensitive to temp

https://t.co/hagE7xRzbi

[Gabriele Ciceri @gabriele_ciceri]

Why human neurons mature so slow?
Is it possible to accelerate their maturation?
Excited to share our work as a preprint. We tackled this question using human pluripotent stem cells (hPSC). Thanks to everybody involved in this work @studerl 1/8

https://t.co/uP9SGaSDsc

[Nan Xu @NanXu4]

@TommyVierbuchen oh no

[Alex Cagan @ATJCagan]

Incredibly excited to share our paper ‘Somatic mutation rates scale with lifespan across mammals’ now published @nature.
https://t.co/a68IkkTt33
An illustrated & updated tweetorial… [1/24]

[Molecular Cell @MolecularCell]

Online Now: Protein degradation on the global scale https://t.co/D2S3cNWSCy

[Nan Xu @NanXu4]

@BriannaNaizir congrats !!!

[Katajisto Lab @KatajistoLab]

Happy to present our latest findings on metabolic bias induced by asymmetric apportioning of aged mitochondria, leading to changes in cell fate and stemness, out in @NatureCellBio https://t.co/U3MyYVDVBr @MetaStem_Center @HiLIFE_helsinki @helsinkiuni @karolinskainst A 🧵1/10

[Zhigang Suo @zhigangsuo]

A statement by Gang Chen posted on his MIT website. https://t.co/ThAfelC3GO

[Bruna Paulsen @bruna_paulsen]

Our new paper is out in @Nature today! In this massive work, we described cell-type-specific neurodevelopmental abnormalities that are shared across 3 top ASD-risk genes. #brainorganoids
@AKedaigle @SilviaM_Velasco @Pigoni_Martina @ArlottaLab @jzlevin Aviv Regev & others 🧵👇

[Brunet Lab @BrunetLab]

Excited to report that our paper on single-cell based 'aging clocks' for regenerative regions of the brain is on bioRxiv!

HUGE congrats to Matt @MatttBuckley and Eric @EricDSun and to our fantastic collaborators at Baylor, UCLA, and Stanford! 🎉

A 🧵

https://t.co/uWosVkG445

[Kevin Stein @KevinCStein]

Fruition of a lot of fun and hard work with the @FrydmanLab! Some new insight into why proteins misfold and aggregate during aging to cause a variety of diseases. @Nature

https://t.co/zCl5fJQgHn

[Juan [email protected] @JuanAlvarezDom]

Are your cells mature? Does it matter? In our latest @CellCellPress, we review Cell maturation: Hallmarks, triggers, and manipulation. We discuss a new framework, based on cell plasticity, to understand how cells become specialized.. @PennCDB @IRM_UPenn
https://t.co/j3owXhlw6b

[Alex Trapp @AlexandreTrapp]

Last week, on the cover of @NatureAging, we published the first computational framework for epigenetic age estimation at single-cell resolution.

A fantastic collaboration with @CsabaKerepesi and @VadimGladyshev in the @gladyshev_lab @harvardmed!

https://t.co/2QXfmVqXh4

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