I’m excited to share a new preprint from some of my work in the lab of @todd_macfarlan ! 😄
We dived into young KZFP gene clusters in different mouse strains and species to uncover mechanisms that facilitated their evolution and diversification in mice
Finally out! We present EXTRA-seq, a new EXTended Reporter Assay to quantify endogenous enhancer-promoter communication at kb scale!
https://t.co/FCZccqJQSt
A 🧵about what it can do:
Find out how genome loci are anchored to the nucleolus!
Exciting preprint @Trono_Lab shows that ZNF274 competes with CTCF to keep H3K9me3 silenced genome at the nucleolus periphery, fine-tuning cell-specific gene expression.
preLight: @Silviacamoeira ⬇️
https://t.co/e5ozAKW0oX
Le Dr Claire Rougeulle, @CRougeulle, est nommée directrice du Centre de recherche de l’@institut_curie. Sa nomination le 3 juillet 2024 par le Directoire de l'Institut Curie, marque le début d'un mandat de 5 ans.
➡️ https://t.co/Ks7rZNqz7y
Excited to share our effort to understand mechanisms underlying the potential for gastruloids self-organisation! #Gastruloids#InNumberWeTrust#EMT
https://t.co/cb6QQ7LIZ9
1/11
Our paper is now out! Cell damage regulates expression of lipid-modifying enzymes via alternative transcription. @SARSCoV2 exploits this to boost Spike #acylation#palmitoylation and generate more infectious #virions! @FS_Mesquita@AbramiLaurence
https://t.co/1vGgyz6uiW
How does the segmentation clock instruct cells to form a somite boundary? Read our new pre-print “Clock driven waves of Tbx6 expression prefigure somite boundaries”, by @Olivier_Venzin and colleagues, to find out.
https://t.co/23LwXR3aUT
Summary thread below: 1/15
Check this out: #lncRNA genes may exert their function through distinct mechanisms in different species. Thanks @JeffOui94@ORSPF@Huret_C and all for your efforts. Stimulating collaboration with @RuggGunnLab and @heard_lab
https://t.co/epnMQSV0gk
SO HAPPY that this paper is finally out. Congrats to all involved (especially @ORSPF, @CRougeulle) for this career changing endeavour! After several attempts, I'm delighted that this has found a welcoming home in @NAR_Open (🙏 review process)
#lncRNA
1/
https://t.co/3qW6TUjaUG
Express delivery from the @jbloom_lab arrived today!
Thank you very much @khdcrawford for sharing your plasmids for #SARSCoV2 neutralization assays from your recent @biorxivpreprint with us - we really appreciate it!
https://t.co/VHeVuBmITs
Let the pseudotyping begin...
Working from home has reached a whole new level! Steve Henikoff is superexcited running his experiments using the CUT&Tag@home setup (PC: Jorja Henikoff). If you want to set this up, here is the link to CUT&Tag@home protocol
https://t.co/wxnsfc5fc2
1/3 We had this recent #bioRxiv preprint from @todd_macfarlan and @Trono_Lab at our first Zoom-JC: https://t.co/DzeJkgVVrE. Very interesting study! Highlights include: large-scale ChIP-seq analysis of young KRAB-ZFPs in mouse followed by megabase CRISPR-deletion of KZFP clusters.
Didier Trono, a professor at @EPFL_en ’s Laboratory of Virology and Genetics, answers some common questions about SARS CoV-2 and the disease it causes, #COVID19.
https://t.co/v2bznGioKU
Day 1 of remote working due to #coronavirus.
Well done @EPFL_en for taking the right measures and sending everyone to work from home - I hope other institutions across Europe do the same!
Let's all work together and do our part to #FlattenTheCurve of #COVID19