Sandoz Patrick

Assistant Professor at SciLifeLab / Uppsala University. Interested in immune cell signaling, microphysiological systems and biophysics.

[Quirin Hammer @QuirinHammer]

Happy to share the final work from my post-doc with @MalmbergLab published in @CellStemCell today https://t.co/ZcC8Q32kts
extensive 15-post-🧵 below

[Taras Kreslavsky @TKreslavsky]

Happy to see our story on tolerance to inflammation antigens @NatImmunol https://t.co/DvEZswDvKO It grew from a naive question I had at my first immunology class: if some self molecules are only induced by pathogen how does immune system distinguish them from foreign antigens?1/n

[Erdinc Sezgin @Sciezgin]

⚡️New preprint out! #Immunology #biophysics
1/ We show hidden functional immune cell states based on collective membrane properties, which are not directly visible via cell surface markers.
https://t.co/Y4F9tUve0F

[VDG Lab @ EPFL @VDGLab]

Our paper is now out! Cell damage regulates expression of lipid-modifying enzymes via alternative transcription. @SARSCoV2 exploits this to boost Spike #acylation #palmitoylation and generate more infectious #virions! @FS_Mesquita @AbramiLaurence
https://t.co/1vGgyz6uiW

[Sandoz Patrick @PatrickSandoz]

An important limitation for serial killing is the low amount of perforin available and the lack of synergy between granzyme B and perforin. The γδ T cells that generated higher co-occurrence of granzyme B with perforin in the lytic vesicles correlated with longer killing series.

[Sandoz Patrick @PatrickSandoz]

Wonderful to see our work finally published @NatureComms! Big congratulations to all the collaborators @onfeltlab, @MalmbergLab, @ealici and especially to Kyra for her first Ph.D. article! @scilifelab @KTHuniversity https://t.co/ONkralrgNh

[Sandoz Patrick @PatrickSandoz]

Interestingly, their lytic potential is higher on the 3rd/4th day rather than after a 14-day expansion which corresponds with the granzyme B expression peak.

[Sandoz Patrick @PatrickSandoz]

@QuirinHammer Thank you Quirin! :)

[Taras Kreslavsky @TKreslavsky]

We are desperately looking for IL17RA-/- mice in Europe for a really cool gdT cell project. Would anyone know who might have them?

[SciLifeLab @scilifelab]

“Women today still have to fight in an arena with unspoken rules and an agenda that are set by men” says Ylva Engström, Chair of the SciLifeLab board & Professor at @stockholmuniversity.

#EmbraceEquity #IWD2023 #InternationalWomensDay

[Sandoz Patrick @PatrickSandoz]

Very excited to see our work from my time as a PhD @VDGLab finally published! Big congratulations to the entire team for such a resilience! @gvdgoot @Vassily_13 @FS_Mesquita @homotopykat @labriataphd @AbramiLaurence
#organelle #Endoplasmic_Reticulum #ER #acylation

[Erdinc Sezgin @Sciezgin]

can't stop watching this! A fascinating example of dynamism inside a cell #microtubules

[Sarahi L. Garcia @sarilog]

My friend @DelemotteLab is preparing for a class on data-driven life sciences. The main aim is to teach how to read quantitative biology. Do you have a suggestion where large datasets are analyzed using some modeling/machine learning. A plus if the data/code is openly accessible

[Taras Kreslavsky @TKreslavsky]

We are looking for a postdoc bioinformatician for very exciting single cell multiomics projects. Please spread the word. https://t.co/ZAwZGGpa10

[Erdinc Sezgin @Sciezgin]

With @LeventalLab , we are organizing a special issue for @BiophysJ "Membranes in Focus" open for microscopic, spectroscopic, and computational investigation of biomembranes. If you are at #bps2022 catch @LeventalLab to discuss.
Submit your work by June 30th.

[Erdinc Sezgin @Sciezgin]

A short review on cell-derived giant plasma membrane vesicles (GPMVs).. their recent applications on phase separation, lipidomics, drug delivery, lipid-protein interactions and membrane dynamics.. their limitations and potential future developments..
https://t.co/0RaQQSjJ1t

[Li Tang @Tang_Lab_EPFL]

Our lab's new paper (https://t.co/rlaQP5YZPe) is now out at @NatBME. We discovered that cancer cells lower their cortical stiffness, which impedes T cell-mediated cytotoxicity by decreasing T cell force at the immune synapse (https://t.co/S7Yom3S3vu) (1/)

[Sandoz Patrick @PatrickSandoz]

@neilemccarthy @forum_gd Thank you very much Neil!