Penn Center for Genome Integrity

PCGI's mission is to integrate cutting-edge research in basic and clinical sciences to advance our understanding of genome integrity.

[Penn Center for Genome Integrity @PennGenomeInteg]

We're thrilled to announce PCGI Postdoc, Arindam Datta (Greenberg Lab), has published work showing that the BRCA1-A complex blocks replication fork reversal to restrict DNA end resection, defining the molecular basis of chemotherapy response in ATM-mutated cancers:

[Roger Greenberg @RogerRogergr]

Congratulations to Arindam Datta @arindam_datta1 on publication of “The BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells”. https://t.co/LtamRWHjB9

[Penn Center for Genome Integrity @PennGenomeInteg]

Congratulations to one of our PCGI trainees, Haoyang Jiang!

[Roger Greenberg @RogerRogergr]

Thrilled to announce that postdoc, Haoyang Jiang, has been awarded an NCI Pathway to Independence Award (K99/R00) for his project, "BLM-Driven Recombination at Alternative Lengthening of Telomeres and Non-Telomeric Sites." Congratulations Haoyang on this well deserved award!

[Penn Center for Genome Integrity @PennGenomeInteg]

Looking forward to the next PCGI Mini Symposium session on "Single Molecule Approaches to Genome Stability" on Monday, May 11, featuring Drs. Eric Greene (Columbia), Michelle Wang (Cornell), and Johannes Walter (Harvard) in the Gaulton Auditorium. https://t.co/2yKch8ZFdf

[Penn Center for Genome Integrity @PennGenomeInteg]

Yesterday, we enjoyed a wonderful round of talks by guests John Maciejowski, @J_Maciejowski, Sergei Mirkin (Tufts), with colleague Kavitha Sarma @sarma_lab, plus Piero Lamelza & Abby Hwang, at PCGI’s Mini Symposium on “Unusual DNA Structures." Our thanks to all who attended!

[Penn Center for Genome Integrity @PennGenomeInteg]

Congrats to PCGI Core Faculty Drs. Mia Levine and Mike Lampson for their paper in @CurrentBiology showing how telomere length is inherited, opening new possibilities for aging and cancer research; featured in Penn Today:
https://t.co/URcBkth1qm

[Penn Center for Genome Integrity @PennGenomeInteg]

We are thrilled to announce PCGI Core Faculty Member Dr. Dennis Discher has been elected to the American Academy of Arts & Sciences @americanacad, please join us in sending him a huge congratulations! https://t.co/iXFy1KojX4

[Penn Center for Genome Integrity @PennGenomeInteg]

Session topic was “Pressures to genome integrity during development & regeneration." This PCGI Mini Symposium was our last this year, we'd like to thank everyone who participated & attended for a wonderful series. We'll post what comes next to our website: https://t.co/2yKch8ZFdf

[Penn Center for Genome Integrity @PennGenomeInteg]

Had a fantastic round of talks yesterday thanks to guest speakers Drs. Yukiko Yamashita (MIT), Zuzana Tothova (Broad Institute), & Tony Huang (NYU), with Drs. Hongjun Song (Neuroscience @UPenn_SongMing), Daria Babushok (Med/Pediatrics @BabushokLab), & Hiroki Akizawa (Plachta Lab)

[Penn Center for Genome Integrity @PennGenomeInteg]

Enjoyed a terrific round of talks yesterday by Drs. Paula Cohen (Cornell), Scott Keeney (MSKCC) & Srinivas Viswanathan @srviswanathan, with trainees @damian_dudka & Cara Brand for our PCGI Mini Symposium on Sex Chromosomes and Meiosis

[Penn Center for Genome Integrity @PennGenomeInteg]

We are excited to report work from PCGI Director @RogerRogergr together with Elton Zeqiraj and Joe Salvino on the discovery of BIRSC deubiquitinating enzyme inhibitors for inflammatory indications https://t.co/g5sfYWJqPA.

[Roger Greenberg @RogerRogergr]

Please see our discovery of first-in-class BRISC deubiquitylating enzyme inhibitors https://t.co/OXmr1CGra8. A great journey with Elton Zeqiraj, Francesca Chandler, Joe Salvino. High-throughput screens, cryo-EM structure and ontarget activity to reduce inflammatory signals.

[Penn Center for Genome Integrity @PennGenomeInteg]

We enjoyed a great round of talks by @CicciaAlberto (Columbia), @LeeZou8 (Duke), Dr. Agnel Sfeir (MSKCC), and @ranjitbindra (Yale), plus our trainees @arindam_datta1 and Azrin Jamalruddin at yesterday’s PCGI Mini Symposium on "Targeting the Damage Response"

[Roger Greenberg @RogerRogergr]

Check out fascinating new work from PCGI leadership Ben Black and Mike Lampson on the role of sequence dependent satellite DNA shape and packaging in female meiosis. https://t.co/ES3pPpMP1u

[Penn Center for Genome Integrity @PennGenomeInteg]

Congratulations to PCGI Core member Kathy Liu on her recent papers on DDX3X RNA helicase in Nature Communications and Current Biology!

[Liu Lab (Dr. Kathy F. Liu) @LiuFange]

In the spirit of Thanksgiving, we're serving up some science! Thrilled to share our new work on sex chromosome homologous proteins DDX3X and DDX3Y, — now published in Nature Communications! https://t.co/SB7Vbk8cqs

[Liu Lab (Dr. Kathy F. Liu) @LiuFange]

The second Thanksgiving science dish we’re serving up is here, excited to share our new work on sex chromosome homologous proteins DDX3X and DDX3Y, titled “RNA helicases DDX3X and DDX3Y form nanometer-scale RNA-protein clusters that support catalytic activity” in Current Biology!

[Penn Center for Genome Integrity @PennGenomeInteg]

We thoroughly enjoyed talks yesterday at our PCGI mini symposium on “Double-stranded RNA recognition & signaling”, a special thanks to speakers Qin Li @QinA2I, Katalin Susztak @KSusztak, Jie Chen @JieChen_Z (Greenberg Lab) and Hyojeong Abby Hwang (Liu Lab)!

[Penn Center for Genome Integrity @PennGenomeInteg]

Congratulations to PCGI Core Faculty member Andrew Modzelewski for his Packard Fellowship Award!

[Andrew Modzelewski 🧬🐁🔬 @TheModzLab]

I’m honored and grateful to be part of the #PackardFellows class of 2024!🐁🧬🔬🎉😭With the help of the Packard Foundation’s funding, I look forward to researching new ways to study retrotransposon reactivation in development and disease @pennvet @PennCDB https://t.co/Dv8jZpVNkm

[Hannah Trost @HannahTrost1]

Grad students and postdocs!!

Please join us at the 2025 @GordonConf
GRS on Mammalian DNA Repair on Feb 1-2 with @LabLegube as our keynote speaker!

Talks selected from submitted abstracts

Register here: https://t.co/onutGLpBfA

[Penn Center for Genome Integrity @PennGenomeInteg]

We’re proud to share a member of the PCGI, Kohli Lab postdoc Dr. Noa Erlitzki, has been named a Doctors For America 2024/25 Copello Health Advocacy Fellow. Congrats, Noa! @KohliLab @NoaErlitzki @drsforamerica

[Penn Medicine CSO @PennMedCSO]

Congratulations to Ben Black (@BB_UPenn/ @PennGenomeInteg/ @PennEpiInst) on being named to the shortlist for @Falling_Walls #ScienceBreakthrough of the Year 2024! https://t.co/A19a7ct6l6 Learn more about Dr. Black & his research➡️ https://t.co/PNIXL9KHaU

[Penn Center for Genome Integrity @PennGenomeInteg]

Congrats to the Bernstein Lab in PCGI for their pub in @NatureComms!