Here GRK-biased β2AR partial agonists are identified as promising oral alternatives to injectable incretin mimetics used in the treatment of type 2 #diabetes and #obesity@CellCellPress https://t.co/8wyCuKvDTz
Biased adrenergic agonists – a novel treatment for diabetes! Amazing paper in Cell from a project led by @ProfBengtsson (Stockholm Uni) and Shane Wright (Karolinska Inst):
https://t.co/OZLcwTCRRc
Great work by my student Nour Kahlous, who performed simulations of the compounds.
Some journeys are long. This one took 15 years!
Our new @CellCellPress paper details a new class of GRK-biased agonists that reshape body composition by reducing fat while sparing muscle, offering a solution to the #GLP1 challenge.
With a strong safety profile confirmed in our first-in-human trial, we are now advancing to a larger Phase 2 study.
My deepest gratitude to every co-author, our partners, and the team at @AtrogiAB for making this vision a reality.
@Stockholm_Uni@karolinskainst@uppsalauni@UniofNottingham@MonashUni@UCPH_Research
This is a great snapshot of the current non-peptide #GLP1R agonist pipeline. The development of a convenient oral pill could be a game changer for treating #T2D and #obesity
Individuals with class 3 obesity (BMI > 40) have up to 17 years of lower life expectancy.
Compare this to smokers who have 8.9 years of lower life expectancy to non-smokers.
#ADA2024#ADASciSessions
Presented at #ADASciSessions:
In the REDEFINE 1 phase 3a trial, semaglutide at a dose of 2.4 mg with cagrilintide at a dose of 2.4 mg led to significant body-weight reduction in adults without diabetes and with overweight or obesity. Full trial results: https://t.co/4ApXFlhZP1
@ADA_DiabetesPro
Hi #AcademicTwitter ! I have a fully funded PhD position available in the Department of Molecular Biosciences at Stockholm University. 🧪🥼🔍
Read more 👇
https://t.co/DNpf2lFPsp
Application deadline: 07/01/2023
#physiology#sciencetwitter#PhDposition
#Exercise is good for everyone, but not everyone responds the same🚴♀️. People with type 2 #diabetes have enhanced #inflammation in skeletal #muscle after acute exercise. Check our publication in @ScienceAdvances! https://t.co/2f4QAvojbo Image credits: @Csilph
▪️Ketogenic diet has been the top diet over the last 5 years
▪️Obesity has risen to unprecedented heights over the last 5 years
🤔 @DrNadolsky @JohnSpeakman4
A timely reminder by my fabulous colleague @YongguoLi and myself: "Uncoupling Protein 1 Does Not Produce Heat without Activation" - https://t.co/dwNrM5ziBt
Idag är det #WomenInScienceDay
Lyssna till ett nytt avsnitt av podden Insights to Science där 5 kvinnliga forskare vid @Stockholms_univ intervjuas av @cloudcyclist om hur de blev forskare och ger råd till unga forskare. #WomenInScience#scicomm#forskkom https://t.co/8QWZjUVmt5
For the next three weeks, we will take you through the mitochondria to show you how it works. Let's start by zooming in to this awesome organelle. #3D#biology#mitochondria#ATP#animations
Nytt nummer av SU:s nyhetsbrev. Med forskning om #hedersvåld 20 år efter mordet på Fadime Sahindal, rymdteleskopet James Webb #JWST, om #diabetes, att farlig #PFAS slungas upp på land från havet, en ny supernova, #entreprenörskap mm Läs o prenumerera: https://t.co/gYlhe220kY