Hamza Bokhari

Executive Director - Preclinical Strategy & Business Development at Atrogi AB | PhD

[Nick @renegadesilicon]

Please, don't get sucked into pretty diagrams. The method here is as banal as possible, has been around forever, and if you swapped PCA for some other nonlinear method or changed the target dimension or used a different interplolator, you would recover a different manifold and, thus, all the steering paths would be different.

Claims like "the model thinks in exactly this geometric shape!" is downstream of the human methodological choice; nothing to see here.

Carry on.

[Sam Bowman @sleepinyourhat]

(I encountered an uneasy surprise when I got an email from an instance of Mythos Preview while eating a sandwich in a park. That instance wasn't supposed to have access to the internet.)

[Daniel Litt @littmath]

Here at [famous scientist’s name].ai, we’re developing tools to accelerate science. Unlike academia, which has stifled the production of high quality scientific work by demanding it be correct, here at [fsn].ai, we know that you can just do (wrong) things.

[Hamza Bokhari @hamzbok]

@davidmbudden @ratimics_ai @chowell2000 @plain_simon Mr @davidmbudden .

Vibe it out, I have faith.

[Hamza Bokhari @hamzbok]

@Sauers_ Try using MCP

[Harsharan Bhatia @HarsharanBhatia]

Thrilled to share our work on DISCO-seq, which combines RNA-preserving tissue clearing with whole-organ 3D imaging to enable anatomically unbiased single-cell transcriptomics, with applications in cancer & infection biology.
#SpatialBiology #SingleCell #Transcriptomics #DISCOseq

[K-Dense @k_dense_ai]

We're honored to be recognized by Anthropic for our contribution to the Skills ecosystem through Claude Scientific Skills. The biggest and most capable scientific capabilities you can provide an agentic system. https://t.co/9ZfdZPV2UI

[atul deshmukh @atul_deshmukh1]

Check out our recent collaborative work with @morten_hostrup. We performed muscle proteome analysis in female across menstrual phase and reveal phase-specific adaptations to sprint interval training.

https://t.co/H63hzcweL9

[Tore Bengtsson @ProfBengtsson]

Our recent work was highlighted in @NatRevDrugDisc !

Read more at:
https://t.co/xuhUOWM3R2

[Hamza Bokhari @hamzbok]

RT @ProfBengtsson: Some journeys are long. This one took 15 years!

Our new @CellCellPress paper details a new class of GRK-biased agonist…

[Cell @CellCellPress]

Now online! GRK-biased adrenergic agonists for the treatment of type 2 diabetes and obesity https://t.co/AEPCqM6Fzg

[atul deshmukh @atul_deshmukh1]

New publication in @CellRepMed

We mapped the phosphoproteomic landscape of insulin & exercise in human skeletal muscle (same individuals) and discovered REPS1 as a new regulator of muscle glucose uptake.

https://t.co/yCx72YmAkx

@morten_hostrup @JeppeKjrgaard @Metabolcenter

[atul deshmukh @atul_deshmukh1]

Thrilled to share that our preprint mapping proteomic & phosphoproteomic signatures of NGT, T2D, males & females — before and after hyperinsulinemic-euglycemic clamp — is now accepted in Cell.

Thank you to everyone involved!

https://t.co/XBpQAHAd6m

[Daniel J Drucker @DanielJDrucker]

A greater risk of progression to hip and knee OA among obese and non-obese diabetic GLP-1-RA users Biology vs. Greater activity? https://t.co/UeLL2qWimN

[Martin. Jastroch @MartinJastroch]

Kudos to Kathy Grabek and Ryan Sprenger for nicely highlighting our work in The evolution of thermogenesis in mammals | Science https://t.co/BQKlvVtuw8
https://t.co/QN3uUiKJyv

[Daniel J Drucker @DanielJDrucker]

The authors position ATR-127 as a highly effective, novel β2- and β3-ARs agonist that increases BAT thermogenesis, holding great therapeutic promise for the treatment of #obesity and its comorbidities @MolMetab
https://t.co/LuJ15ot05V

[Martin. Jastroch @MartinJastroch]

Scrutinizing claims on functional UCP1 in elephant seals: Why the big fellas have lost it and the little guys didn’t…
Terrestrial birth and body size tune UCP1 functionality in seals https://t.co/dBCvQmb0GW

[Lee Mordechai @LeeMordechai]

1/ I’m an Israeli academic. My community is too silent about the ongoing war in Gaza. Here is how I see things based on reading hundreds of articles and watching thousands of videos and images about the war. This tweet chain contains my conclusions as a sort of executive summary.

[James L. Nuzzo, PhD @JamesLNuzzo]

NEW: We updated the REPS-%1RM table that has been printed in the NSCA textbook for ~20 years

One table for leg press
One table for bench press
One table for all other exercises

Published #OpenAccess @SportsMedicineJ
Authors:@MatheusdPinto @JamesSteeleII
https://t.co/zBqPMudWIM

[Novo Nordisk Foundation @novonordiskfond]

People of South Asian descent have a higher risk of developing type 2 diabetes, but a lack of research means we don’t understand why. Shivani Misra, this year’s winner of the Precision Diabetes Medicine Award, given jointly by the European Foundation for the Study of Diabetes and the Novo Nordisk Foundation, is trying to change that.

#EASD2023 @EASDnews @ShivaniM_KC

https://t.co/BFeUhsywnl