Raimundo Castro

Biochemist ❧ PhD Student

[Joe Merrick @JoeMerrick]

Happy anniversary to the last new Pokémon Mystery Dungeon game.

Happy it has been so long since a brand new one. Let's see how long this streak lasts.

[D U N E @AchoDune]

Unpopular opinion:

Heroes of the Storm es mejor juego que League of Legends.

[Raimundo Castro @Ra1m0nd_CL]

@Freya5842 If I remember correctly, it was a shiny tentacool back in Silver when I was 8-9yo.
And if we don't count it since it couldn't be transferred, a Zubat back in Sapphire, in Shoal Cave.

[Flavio Salazar Onfray @DrFSalazar]

TRIMELVax, una vacuna antitumoral desarrollada en Chile es segura e inmunogénica en pacientes con melanoma refractario. Un avance poco frecuente en Latinoamérica es publicado en BJC: ciencia fruto de un esfuerzo multidisciplinario.
#CancerImmunotherapy #Melanoma #Chile #uchile

[Raimundo Castro @Ra1m0nd_CL]

@StarRailVerse1 Castorice 🦋

[William A. Wallace, Ph.D. @WilliamWallace]

B12 maintains myelin through two separate pathways. Both fail at the same time when B12 drops.

Pathway one: B12 converts homocysteine into methionine, which becomes SAMe. SAMe builds the lipid components myelin is made of. No B12, no SAMe, lipid synthesis stalls.

Pathway two: B12 clears a metabolic byproduct called methylmalonic acid. Without it, abnormal fatty acids get incorporated into the myelin sheath itself. The structure degrades from the inside.

Here is what makes this dangerous. In the Lindenbaum 1988 NEJM study, 28% of patients with neuropsychiatric symptoms from B12 deficiency had completely normal blood counts. No anemia. No macrocytosis. The myelin was already degrading with nothing on the CBC to flag it.

Caught early, repletion can reverse it. Caught late, the demyelination can be permanent.

A normal B12 blood test does not rule this out. MMA is the more sensitive marker.

Scalabrino, Prog Neurobiol, 2009.
Lindenbaum et al., NEJM, 1988.

[Raimundo Castro @Ra1m0nd_CL]

@AboutNodKrai Arapet ❧

[Raimundo Castro @Ra1m0nd_CL]

I'm Nyx, and I earned the Grand Master's recognition in the trial! Come give it a try!

#GenshinImpact #ChallengeVarka #Varka #VarkaTheLegend
@GenshinImpact
https://t.co/Wp39MRLH9G

[Genshin Impact @GenshinImpact]

🎁Now Live: Challenge Varka — Come and Face the Grand Master's Trial!

⚔️ Participate in the event and share it to receive Varka's Primogem gift in your notifications!

#GenshinImpact #ChallengeVarka #Varka #VarkaTheLegend

[Tim Cook @tim_cook]

Happy Year of the Horse to everyone celebrating!

[Reads with Ravi @readswithravi]

The Paradox of Knowledge:

[Science Magazine @ScienceMagazine]

"In the end, I have come to realize that being authentic at work is not a weakness, but rather a strength." #ScienceWorkingLife https://t.co/aoNnrvLywh

[NEJM @NEJM]

Influenza remains an important cause of illness and death. In a phase 3 trial, a nucleoside-modified mRNA (modRNA) quadrivalent vaccine was found to be superior to a standard quadrivalent vaccine in preventing influenza illness. Full trial results and Research Summary: https://t.co/abDJHVnne3

[Lung Cancer Europe @LungCancerEu]

There’s a lot of misleading advice online about “cutting out sugar” or going keto for cancer.

A new Cell study shows the biology is far more complex. When glucose is heavily restricted, tumours can release signals that weaken the immune cells that normally protect the lungs, making it easier for cancer cells to settle there.

Nutrition in cancer care is nuanced & should be guided by qualified professionals - not social media. #LCSM https://t.co/GMefBtOYIK

[🌸panda🌸 @navvyia]

🌸GIVEAWAY🌸

HONKAI STAR RAIL

GUARANTEED CYRENE AND LIGHT CONE
(or any character of your choice)

REPOST, LIKE AND FOLLOW

🌸GOOD LUCK MY LOVELY🌸

[Science Magazine @ScienceMagazine]

In a new Science study, researchers show that lysosomes, degradative organelles activated by food limitation, stimulate epigenetic changes that contribute to transgenerational longevity in C. elegans.

📄: https://t.co/XoUpycVY1H
#SciencePerspective: https://t.co/o2rjQdO1zB

[Dr Rishabh Jain @DrRishabhOnco]

🎗️ Nobel Prize 2025: When immune tolerance met tumor escape!
Mary Brunkow, Fred Ramsdell & Shimon Sakaguchi win for discovering regulatory T cells (Tregs) - the body’s immune “brakes.”

🔬 In oncology, these same brakes often shield tumors from immune attack.
Their discovery paved the way for:
✅ Checkpoint inhibitors
✅ CAR-T refinements
✅ Treg-depleting strategies

💡 From autoimmunity to cancer therapy- the same cells hold both keys!

#NobelPrize #OncoTwitter #Immunotherapy #CancerResearch @OncoAlert @NobelPrize @myESMO @ASCO

[Asimov Press @AsimovPress]

Some fun numbers about the "speeds" of cells:

1. Sugar molecules move at ~250 mph in a cell, about 2x the speed of a Cessna 172 plane.
2. Every protein is hit by ten trillion water molecules each second.
3. ATP synthase (which makes ATP) spins around 8,040 times per minute.

[Raimundo Castro @Ra1m0nd_CL]

@CyreneDaily I did begin at 1.0, then I thought it was boring. Later when I saw Fugue I returned (end of 2.6), lol