Ragusa Lab

Research laboratory @DartmouthChem utilizing structural biology, biochemistry and cell biology to investigate the molecular mechanisms of selective autophagy.

[Ragusa Lab @RagusaLab]

The RagusaLab is now on Bluesky. Come check us out at https://t.co/RF0sBUsWAa

[Dominik Hrebik @F4ustus]

Our new preprint is out: we solved the structures of HIV-1 matrix (MA) from intact virions by SPA. The structure led us to a surprising discovery resolving a long mystery in HIV-1 biology – peptide SP2 regulates the maturation of the HIV-1 matrix. 🧵1/x
https://t.co/oBuTqvsdTN

[Ragusa Lab @RagusaLab]

We get so focused on research it can be hard to take a step back and listen to other peoples stories. Check out @dartmouth postdoc @SukrutKamerkar's excellent perspective on supporting one another, published in @ScienceMagazine .

https://t.co/toJzKHOQmk

[Wade Zeno @ZenoResearch]

It's known that anionic lipid charge enhances alpha-synuclein's ability to bind membranes. But did you know that alpha-synuclein can preferentially bind to neutral membranes when they are full of packing defects?

Read about it in our latest preprint!

[Dartmouth Postbac Research Education Program @DrtmouthPostbac]

Come check us out at booth 1131 for a research-immersive trainee-focused postbac program with an emphasis on wellbeing! @ABRCMS!! #ABRCMS

[Alex Agrotis @aagrotis]

Pleased to see our paper now published in Autophagy Reports!

Great work from all involved to discover more about how "protein ATG8ylation" works.

The big question is still "why?"

"ATG5 is dispensable for ATG8ylation of cellular proteins"
https://t.co/tnHRZiSsTT

[Katherine Mirica 🇺🇦 @KMirica]

Come be my colleague! @DartmouthChem has an opening for an Associate/Full Professor in Materials Chemistry:

https://t.co/GZADHj3ICI

[Ragusa Lab @RagusaLab]

Our work on the biochemical reconstitution of mitophagy initiation led by @Devika_An has been updated on bioRxiv. You can check it out at https://t.co/zcWQSHK28n

[Ragusa Lab @RagusaLab]

Can you reconstitute tethering using three-color imagining to monitor protein localization at tethering sites in vitro? Yes!

Can you distinguish between membrane binding and tethering with a single assay? Yes!

Can you monitor tethering in real-time? Yes!

[Ragusa Lab @RagusaLab]

New paper up on bioRxiv https://t.co/VqNKaWeO9g
Awesome work from @Devika_An demonstrating what types of tethering you can reconstitute with GUVs and liposomes in vitro.
She also shows that Atg11 can bind some membranes and recruit them to Atg32 coated GUVs.

[Ragusa Lab @RagusaLab]

@jmdelgado_ @embojournal Congrats Jose! It's been fantastic getting to see this work evolve over the years.

[Viola Nähse @ViolaNahse]

I am very happy our DFCP1 story is out! Since many years, DFCP1 has been used as an omegasome marker, but its function was totally unknown. Here we show that DFCP1 is an ATPase required for selective autophagy.
Here are the main points of the paper:
1/8

[Ragusa Lab @RagusaLab]

@chemgonzalezlab @DartmouthChem Welcome Miguel! Looking forward to seeing you around Burke. Also just checked out your lab website and it looks awesome.

[Gonzalez Lab @chemgonzalezlab]

Excited to announce that the Gonzalez Lab (https://t.co/O0R88PNTd9) will open its doors when I join @DartmouthChem as an Assistant Professor of Chemistry in Fall 2023! (1/3)

[Sharon Tooze @sharontooze01]

Very happy to see our paper now online. Great work from Wenxin, Taki and our fantastic colleagues #autophagy #crick @wencyzh @Sci_Lipi
https://t.co/pgbKkoSHZ7 @eLife

[Ragusa Lab @RagusaLab]

Huge congratulations to these three awesome Ragusa Lab Ph.D. students who all returned to Hanover to participate in graduation last weekend. Congratulations Dr. Bauer, Dr. Leary and Dr. Reinhart!

[Jacquelyne Read @JacquelyneRead]

Have a Ph.D. in organic chemistry but want to gain experience applying data science to reaction development? The Read Lab @DartmouthChem is hiring a postdoc! See https://t.co/mNPUrb5e9m for more info. Please RT. #chempostdoc

[Kevin John U. Butay @Gagamboy18]

Our paper is out! Congratulations to @Cassandra_Hayne @TheHayneLab @RobinStanleyLab at @NIEHS ! I had fun image processing this project! https://t.co/rz8kfsQhWs

[The Kettenbach Lab @KettenbachLab]

Super excited to share a review article by @Nguyen_T_Hieu and myself on Substrate and phosphorylation site selection by PPPs! https://t.co/tnhn0z5Nar

[Journal of Cell Biology @JCellBiol]

.@tjolivas, Yumei Wu, @shenliang_yu, @TJ_MeliaLab et al. @YaleCellBio show that ATG9 vesicles are the membrane seed for mammalian autophagosomes using nanodisc technology https://t.co/5LwAuDcYaN

@PDClab
@GuptaLab1
@1in_1uan
@em_guinn
@ShantaNag1

#autophagy