Fernando Gonzalez

MD, PhD @sahlgrenska & @goteborgsuni 🇸🇪

[JAMA Network Open @JAMANetworkOpen]

Blood total tau, phosphorylated tau, and brain-derived tau were elevated after multiple traumatic injuries, correlating with injury severity and outcome, with sustained BD-tau elevation in the acute phase. https://t.co/djEkg1fMFU

[Science Magazine @ScienceMagazine]

Monitoring markers of tau protein in the blood can predict functional outcomes in patients recovering from ischemic stroke better than MRI, according to a comprehensive study of more than 1200 patients in @ScienceTM. https://t.co/g4ZgO2CZuR

[JAMA @JAMA_current]

A recent study showed that newborns have high levels of p-tau, a biomarker for #Alzheimer disease.

Understanding how infants clear the protein could help prevent aggregation, which leads to #neurodegeneration in adults.

https://t.co/vDj5Ip4OmK

[@BrainComms @braincomms]

Gonzalez-Ortiz et al. report plasma p-tau217 measurement in newborns; levels are significantly higher in healthy newborns than in AD patients. Levels of serum p-tau217 in premature newborns remain increased up to 18 weeks post birth (https://t.co/nOjb3iamJZ)
@Rantes

[JAMA Neurology @JAMANeuro]

Differentiating between MCI subtypes in individuals attending memory clinics was associated with the diagnostic performance of blood p-tau217 models to determine brain amyloidosis in patients’ clinical management. https://t.co/MDOvCLG6b8 @Rantes_

[Samir Abu Rumeileh @s_rumeileh]

Check out our new study!
☑️p-tau 181 and 217 in blood are not as specific for AD as previously thought,
☑️they are also elevated in the blood of patients with ALS,
☑️IHC and MS analyses disclosed both p-tau species in muscle biopsies from ALS cases.
https://t.co/nhyQdQ6hms

[Nat Rev Neurology @NatRevNeurol]

Plasma p‐tau217 identifies cognitively normal older adults who will develop cognitive impairment in a 10‐year window https://t.co/g2ZEMbsr9D

[Nat Rev Neurology @NatRevNeurol]

Phospho-tau serine-262 and serine-356 as biomarkers of pre-tangle soluble tau assemblies in Alzheimer’s disease https://t.co/vpW5Abs3Mo

[JIM - Journal of Internal Medicine @JInternMed]

New article reports a strong correlation between plasma BD-tau and infarct volume in acute ischemic stroke.

➡️BD-tau adds prognostic value for clinical outcome after stroke.
➡️Could BD-tau be the troponin of the brain?

🔗https://t.co/II6XvUHLDq

#IschemicStroke #troponin

[Stroke AHA/ASA @StrokeAHA_ASA]

#STROKE: Plasma brain-derived Tau levels on admission can accurately discriminate for 90-day good outcome (mRS 0-3) among acute ischemic stroke patients after successful endovascular therapy. #AHAJournals https://t.co/fVRzWeeuoa @neuro_varela @chusaojoao @UPorto @Rantes_

[Nat Rev Neurology @NatRevNeurol]

Plasma brain-derived tau is an amyloid-associated neurodegeneration biomarker in Alzheimer’s disease https://t.co/NXPEjWma6B

[Thomas K. Karikari @TommyKakari]

In @NatureComms, we validate plasma BD-tau as AD-type N marker:

- BD-tau is amyloid driven & assoc. w/ atrophy;

- Abnormal p-tau & BD-tau confers faster cognitive decline and atrophy;

- BD-tau is less responsive to kidney fxn effects.

https://t.co/u3qvLikEaC

@Rantes_

[Neurology Journal @GreenJournal]

According to this study, brain-derived tau is a promising blood-based biomarker of ischemic stroke outcomes. Learn more: https://t.co/mVlidcnl9G

[Fernando Gonzalez @Rantes_]

We have shown the performance of plasma BD-tau as a neurodegeneration marker, but what about tracking acute neuronal injury? The results of BD-tau in the precision medicine in stroke cohort (PROMISE) are presented in this very elegant paper 👇 🧠🩸

[Fernando Gonzalez @Rantes_]

@LogarithmicDis @Ugot At the moment there’s no p-tau217 data in the QC program but it’s planned to be included early next year 😄

[Fernando Gonzalez @Rantes_]

Happy to share our first @ugot (UGOT) p-tau217 publication. We developed the first academic immunoassay for p-tau217 in blood and checked its performance focusing on preclinical and prodromal AD.

https://t.co/MvmqqFjYUb

[Fernando Gonzalez @Rantes_]

Thanks to our amazing collaborators @BarcelonaBeta and @PittADRC

[Fernando Gonzalez @Rantes_]

- Capable of identifying Aβ positive individuals, assessed either by amyloid PET or Aβ 42/40 ratio in CSF, even in early stages of the disease continuum.
- Strong correlations with blood p-tau217 measured by IP-MS
- Stronger correlation with plasma BD-tau than with plasma NfL

[Fernando Gonzalez @Rantes_]

@PittPsychiatry @LabPascoal @Pamlukasewicz @BellaverBruna @PittHealthSci @TharickAPascoal Congrats @Pamlukasewicz !

[Fernando Gonzalez @Rantes_]

Happy to share our most recent publication, where we explore the performance of plasma BD-tau and p-tau181 in Alzheimer’s disease and rapidly progressive dementias, including Creutzfeldt-Jakob disease 👇

@TommyKakari

https://t.co/yz7O4M6gFR