Renee Pepper

Post-doc at @JohnsHopkins with @EManiax
Neuroscience PhD from @UTAS_
Glia at the synapse 🧠
she/her 🏳️‍🌈

[Renee Pepper @Renpeps]

@jackie_griswold & @EManiax's text book changing paper is out🔍seeing is believing they say and here we see beautiful pearls on a string.. not just in EM but in live cells too! Proud to have contributed to this work by showing how these pearls impact physiology and plasticity 🧠

[watanabe lab 🔬 @EManiax]

Perhaps the last x tweet! Excited to share our latest findings, now published @NatureNeuro https://t.co/eISiXebEI0

We found unmyelinated axons exhibit pearls-on-a-string morphology's due to their membrane mechanical properties.

Threads will follow!

[Marine Biological Laboratory (MBL) @MBLScience]

This new study, led by Shigeki Watanabe & partially conducted in the MBL’s Neurobio course, challenges a fundamental tenet in neuroscience about the shape of axons & proposes a new model for understanding how information is transmitted in the brain. 🧪 🧠
https://t.co/amRrJrR6wu

[Nature Neuroscience @NatureNeuro]

Membrane mechanics dictate axonal pearls-on-a-string 📿 morphology and function

@EManiax @jackie_griswold @MayteBQ @Renpeps @CTLeeRes @ValentinNagerl

https://t.co/n7gqz0PIde

[ZucheroLab @ZucheroLab]

Delighted to share our latest work “Oligodendrocyte calcium signaling is required for actin-dependent myelin sheath extension” was published online today @NatureComms! Led by former grad student, @_manasi_iyer_! (1/n)

[Renee Pepper @Renpeps]

Dear twitter brains trust, I am just starting to work on a K99 application for next year. Is there anyone out there who would be willing to share their application? 🙏

[watanabe lab 🔬 @EManiax]

Please RT! We are hiring a lab technologist! If you are interested, please dm or click the link below!
https://t.co/6uzHPgBu5m
(We also have openings for postdocs!!)
https://t.co/ySiteDkles

[Renee Pepper @Renpeps]

@UnculturedTy was one of my first friends in the US. Little did we know we would be on a paper together 4 years later. Very proud of all your hard work 🎉

[watanabe lab 🔬 @EManiax]

Vesicles fuse and release signaling molecules, but how are new vesicles recruited? In this preprint, we show that Itsn1 forms condensates and keeps those vesicles close to release sites for rapid replacement. Congrats to @UnculturedTy and all authors!!

https://t.co/CMeVATKWCs

[Jackie Griswold @jackie_griswold]

My paper is now out in the world - I can't believe it! If you want to read the preview it is up on bioRxiv: Membrane mechanics dictate axonal morphology and function https://t.co/4dUHgEw5OX

[Renee Pepper @Renpeps]

Axons are even more beautiful than we ever thought. So proud to be a part of this incredible work with these amazing scientists. A reminder that the brain can still surprise us and is still our biggest mystery.

[watanabe lab 🔬 @EManiax]

Do you know how axons actually look like? With @RangamaniUCSD, we showed that axons form nano-pearls due to membrane mechanics. Neuronal activity modulates their size by mobilizing cholesterol/altering membrane fluidity, resulting in the AP plasticity. https://t.co/4FyQyZR7Go

[Brad Sutherland @BradASutherland]

Pleased to share our latest paper on microglia pericyte associations published in Glia. Great work by a great team @CathFoster_ @Jake_Cashion_ @ziebs83 @jomaree @DrLachlanSBrown and the twitterless Gary Morris & others. @WickingDementia @UTAS_MedSci #PEM https://t.co/IDVbCs1NNi

[Renee Pepper @Renpeps]

@ZacharyWhiddon1 donkeys

[Renee Pepper @Renpeps]

@AizenmanLab Ultra-fast endocytosis! But maybe I’m biased

[Renee Pepper @Renpeps]

Beautiful work, premyelinating oligos are so fascinating

[Lu Sun @SunLab19]

How is oligodendrocyte number controlled across diverse brain regions? Our preprint showed that autophagy, an evolutionarily conserved cellular process that promotes cell survival under canonical settings, collaborates with apoptosis pathways to kill premyelinating oligos (1/n).

[Renee Pepper @Renpeps]

Wow this was 7 years ago today, graduating from my honors research year. Feels like forever ago. If only baby Renee knew the wild academic ride coming. Small town first gen girl to Dr Pepper at Johns Hopkins.

[Renee Pepper @Renpeps]

@ZacharyWhiddon1 @EManiax Just for you

[Renee Pepper @Renpeps]

I have been thinking about adding my first bottle to the shelf since I joined the lab! 🍾So happy to have received a post-doc fellowship from the American Heart Association. A wonderful way to end 2022, 2023 is looking bright. 🤩Thanks @EManiax for believing in me

[Renee Pepper @Renpeps]

Wow this is amazing! @DrCarlieCullen and my paper was awarded the most significant paper in 2021 in the @AusNeuroSoc! Congratulations team, @LabGlial.

[Young Glial Research Team @LabGlial]

Congratulations to @DrCarlieCullen on her receipt of the 2022 ANS Paxinos-Watson Award for the most significant paper by a member of the Society in 2021 for our paoer 'Nodal and periaxonal plasticities modulate action potential conduction in the adult mouse brain' 😁

[Renee Pepper @Renpeps]

Glia are the answer to everything and you cannot tell me otherwise

[Manolis Kellis @manoliskellis]

This week in @Nature we present our #SingleCell dissection of #ApoE4, the strongest genetic variant for #Alzheimers.
ApoE4 impairs #cholesterol #transport, leading to #oligodendrocyte ER accumulation, decreased #myelination.
Restoring transport restores mouse cognition.
#Hope #AD

[Zachary Whiddon @ZacharyWhiddon1]

Pre-print alert before twitter dies. Please check out my exciting work. I look at taste neuron terminals in taste buds (in a living mouse) while taste cells undergo turnover. These terminals are going nuts!

https://t.co/PVa6tDsq0x

[Silvia Vicenzi @VicenziSilvia]

In a leadership development course, I was asked a very important and thoughtful question:

✨ "in what kind of environment do you thrive?" ✨

🌱 Let's reflect together as a collective 🌱