Rishi J Desai

Faculty at Harvard | Operations lead FDA Sentinel Innovation Center

[Rishi J Desai @Rishidesai11]

Time to ask the question- are your observational studies PRINCIPLED?

At Sentinel, we are setting the bar high for ourselves and hope the community will follow suit!

Check out @bmj_latest describing our process

[The BMJ @bmj_latest]

A five step process guide to help ask and answer a causal question regarding drug treatment effects using healthcare data
@Rishidesai11 https://t.co/aFKeDWXUBc

[Rishi J Desai @Rishidesai11]

Very pleased to see this out in @jmirpub - can we extract timely mortality information from public sources to bridge the gap in capture of death in EHRs for research applications? Promising findings...

https://t.co/6THM3bQUX1

[Rishi J Desai @Rishidesai11]

So to summarize, 5 tests played over 25 days, run fests, tense chases, fifers, handshakes (or lack thereof), sendoffs, blokes showing up on one working foot or with one working arm, and yeah, no winner, still nobody complaining!

A series for the ages #ENGvIND

[Omkar Mankame @Oam_16]

This should be framed. What a capture!
(Via @collinsadam)

[Rishi J Desai @Rishidesai11]

In a world filled with madness and uncertainty, I’m glad we have the purity and serenity of test cricket to hold on to! Skill, determination, belief on full display in London. A cracking opening session on day 4 on the cards tomorrow..

[Proteas Men @ProteasMenCSA]

A phenomenal day for the Proteas, an outstanding all-round performance! 💪🔥

They closed out Day 3 on 213/2, just 69 runs away from securing the World Test Championship Mace. 🏆🇿🇦

Dominant with the ball, composed and clinical with the bat. South Africa stands on the brink of history. 👏🏏

#WTCFinal #WozaNawe #ProteasWTCFinal

[Muthu Vaduganathan @mvaduganathan]

#VICTORIA demonstrated benefits of sGC stimulator vericiguat in recent worsening HF & led to its #FDA approval in '21

New @JACCJournals nationwide analysis finds use thus far has been limited
https://t.co/ZjKkDIkg6G

Will #VICTOR (no recent worsening HF) support its broader use?

[Rishi J Desai @Rishidesai11]

Vericiguat Adherence for Heart Failure With Reduced Ejection Fraction in Routine Clinical Care in the U.S

New RL @JACCJournals Heart Failure, led by star med student Naira Ikram

@mvaduganathan @ankeetbhatt

https://t.co/GtkxhuLJkZ

[Rishi J Desai @Rishidesai11]

Excited to share our latest paper in @AmJEpi led by Janick Weberpals

We introduce high-dimensional multiple imputations (hdMI) to handle MNAR through data-driven identification of auxiliary covariates and show that this approach outperforms standard MI

https://t.co/uds9iGUDMh

[Rishi J Desai @Rishidesai11]

In a study @npjDigitalMed led by Bowen Gu and @JieHealthAI, we find that LLMs struggle to convey uncertainty and can be overly confident in their answer even when it is wrong. Imp area for research and improvement for detection of hallucinations..

https://t.co/Edjr8V5jwP

[Rishi J Desai @Rishidesai11]

@haiderwarraich @US_FDA @ARPA_H Congrats Haider on a highly productive stint at the FDA and all the best for your new role!

[Brigham and Women’s Research @BrighamResearch]

In 2019, the @US_FDA requested a team of investigators to create a new data infrastructure to improve drug safety surveillance research studies. 5 years later, @Rishidesai11 and the team introduce the Real-World Evidence Data Enterprise.

Read more:https://t.co/XN4Jytk3Ry

[Rishi J Desai @Rishidesai11]

@MichaelEMatheny So grateful to have you as a partner in this Michael!

[Rishi J Desai @Rishidesai11]

Thrilled to share that the vision we described 4 years ago is now realized with unveiling of the RWE DE- a fully functional system of 25+ mil individuals with linked EHR and claims data ready to serve the FDA for post marketing surveillance of drugs!

https://t.co/kL8AuWcD0M

[Rishi J Desai @Rishidesai11]

** New paper **

Our vision for integrating large scale EHRs with insurance claims to enhance capabilities of the FDA Sentinel system

https://t.co/xFP5PFGRjT

Working with an exceptional group of investigators who are committed to achieving this goal has been a true privilege

[Rishi J Desai @Rishidesai11]

@noah_greifer Noah I’m curious about your thoughts regarding bag of little bootstraps since you mentioned speed..

[Rishi J Desai @Rishidesai11]

@Michael_Harhay @TheLancet @ecgoligher @UofT @uoftmedicine @UHN @UofT_dlsph Looks fantastic, congrats Michael

[STAT @statnews]

Researchers suggest FDA could use artificial intelligence to enhance Sentinel, the agency's safety surveillance system for drugs and devices. https://t.co/v2U1Kd6Ttv

[Michael Matheny @MichaelEMatheny]

It has been tremendously fun and rewarding to be a part of the FDA's Sentinel Innovation Center, and to work with @Rishidesai11 and a great coauthor group on this thought piece. @CWalshMD @AliAlgaradi @Sharon_E_Davis @dfabbri @kbjohnsonmd

[Rishi J Desai @Rishidesai11]

LLMs are undoubtedly going to be used increasingly in extracting and synthesizing information from free-text EHRs and other sources of data. Very glad share some considerations published in @JAMANetworkOpen led by @MichaelEMatheny..

https://t.co/Ybz45201VR

[Rishi J Desai @Rishidesai11]

@mvaduganathan @scottdsolomon @PSJhund @ValleAlfonso @AndrewJSauer @MkosiborodMD @P_Rossing @brendonneuen @HanCardiomd @ShelleyZieroth @kidney_boy @NMHheartdoc @gcfmd Fantastic news for the patients! Congratulations Muthu

[Rishi J Desai @Rishidesai11]

@FralickMike @JACCJournals @ankeetbhatt @mvaduganathan Thanks Mike, even the “high use” counties per our definition (quintile 5) had use ranging from 20-55%. So much room for improvement here to get patients on these cheap generic life saving meds..

[Rishi J Desai @Rishidesai11]

Very glad to have this paper out in @JACCJournals showing suboptimal local use patterns of triple GDMT for HFrEF correlating with indicators of socioeconomic disadvantage..

https://t.co/f8UjPaaJvr

Shout out to a great team @ankeetbhatt @mvaduganathan

[Rishi J Desai @Rishidesai11]

@prieto_alhambra @HDR_UK @BotnarOxford @UniofOxford @OHDSI Congratulations Dani!