Eti Sinha

Creating software that ultimately improves patient outcomes

@CornellBME PhD’24 alum | @UCSDBE alum

[Alejo Rodriguez-Fraticelli @AlejoFraticelli]

Absolutely thrilled to share with you the final version of EPIclone, out now (open access) in @Nature.

This has been an amazing collaboration with the lab of Lars Velten (@larsplus) at @CRGenomica

https://t.co/BI12Ir7fyz

[WCM Englander Institute for Precision Medicine @WCMEnglanderIPM]

"#AI has applications to improve cancer treatment, according to @WCMEnglanderIPM Director Olivier Elemento, PhD (@ElementoLab). We could use data from thousands of patients to integrate complex information, we can’t do that without using tools like AI.”

https://t.co/mLp6pSIC6A

[Vega Shah @dr_alphalyrae]

It is becoming clear that the AI and biotech intersection holds 3 big opportunities:
1) discovery of molecules and novel drug+target pairings
2) using data to guide clinical experimental design to speed phase I/II and beyond
3) operational efficiency via faster protocols, better automation and relieving admin burden for operators

[WCM Englander Institute for Precision Medicine @WCMEnglanderIPM]

Attending the @ASH_hematology annual mtg?

If so, don’t miss “#AI in #Hematology: From #GenerativeAI to Ethics & Applications,” Chaired by @WCMEnglanderIPM Director Olivier Elemento, PhD (@ElementoLab) December 7th from 4-5:30 pm!

https://t.co/pv9ELbOCnh

[Eti Sinha @SinhaEti]

@bitsinbio hosting another Builder Showcase next week 10/17 in San Francisco with @FutureHouseSF !

Sign-up to attend the event: https://t.co/dOeSjyxasF

If you're building something at the intersection of Bio/Tech/AI, sign up here to present: https://t.co/8TetyiDE8G

[Vega Shah @dr_alphalyrae]

the age of bio has begun

[Ryan Corces @ryancorces]

One of the last stories from my postdoc work with @HowardYChang and @WJGreenleaf is out today @ScienceMagazine led by Laksshman Sundaram. scATAC-seq of 8 different tumor types from TCGA. https://t.co/D521MAbWrH

[Pradeep Natarajan @pnatarajanmd]

Prevention requires bold & forward-thinking investments. My OpEd on why letting funding lapse for @AllofUsResearch would be a step backwards https://t.co/ktGsH6yS6V @statnews

[Pinkal Desai @DrPinkalDesai]

Excited to share this publication !! Congratulations to all my collaborators @AlexBickMDPhD
@mchonig , Paul Auer, Ying Zhou , Alex Reiner, JoAnn Manson , Samuel Handelman among many others!! @WCMLeukemia @WCMEnglanderIPM

[Siddhartha Jaiswal @jaiswalmdphd]

Clonal hematopoiesis is an expansion of blood stem cell clones caused by mutations in a recurrent set of genes. Our paper on factors mediating expansion of these mutant clones is published today.
https://t.co/Q6NeqZz6sm

Thread below...

[Nitya @nityasnotes]

@bitsinbio NYC edition of technical lightning talks is here! Thank you to our speakers and to @persona_nyc for hosting us. RSVP at the link below.

Can't wait to see you all there🧬

[Monica Guzman @DrMonicaGuzman]

Meet the women in our lab! ⁦@WCM_MeyerCancer⁩ ⁦@WeillCornell⁩

[Caitlyn Vlasschaert @DrFlashHeart]

Our paper demonstrating an approach to CHIP curation in large datasets is now out in Blood (@BloodJournal)! 🩸

We identify CHIP in >500,000 individuals and show how common challenges such as sequencing artifacts and germline variants can be addressed.

https://t.co/0P4hMdTV4w

[Cornell Biomedical Engineering @CornellBME]

Loving the relaxed smiles & spirit of this crew of @Cornelleng @CornellBME PhD students who met up for the holidays to enjoy hot chocolate and Christmas decorations at Columbus Circle Christmas Village & Shops, NYC. (L to R: @SinhaEti, Kata Alilovic, Dominick Romano, Xinzi He).

[Adam J. Engler @AdamEnglerUCSD]

WE HAVE A NEW NAME!!!!! Thanks to @UCSDJacobs, @ucsdbe, and all of our amazing staff, students, and faculty. Thank you to Shu Chien for his leadership, and especially @BioLegend CEO Gene Lay for this transformational gift.

[Alex Bick @AlexBickMDPhD]

Published #CHIP datasets are growing exponentially! In a new preprint, we share how to reliably identify CHIP in ~550k @AllofUs genomes & @UKBiobank exomes. We find small parameters make a BIG difference in CHIP quality & disease associations.
https://t.co/QnxY1krg0F

[Josie Kishi @jykishi]

What if you could image 🔬cells and then choose which ones to sequence 🧬?

What if you could go back and image 🔬cells that you previously sequenced 🧬?

Now you can 🔬 then 🧬 then 🔬 cells again with Light-Seq!

https://t.co/ZuDIOfnqyj

Let’s dig in 🧵.

[FWD.us @FWDus]

Dr. Alur, a doctor with a H-1B visa, on the challenges immigration physicians face now: “There were an estimated 15,000 physicians like me that were restricted from being on the frontlines, providing lifesaving services.”

[Anna Nam @AnnaEnim]

Cancer driving mutations are detected across normal tissues. But how do you study their downstream effects if the clonal cells can’t be isolated from the admixed normal cells?

Our work on how we tackled this challenge is out today @NatureGenet! https://t.co/MFBW5BbDug

🧵👇