A sneak peak of a complex and technically challenging experiment that my lab developed: https://t.co/UXXUargZqM. Super proud of PhD candidate Hannah Johnson for showcasing our Whole-gut spatial genomic analysis in #zebrafish.
This video illustrates one landmark in the protocol after multiple rounds of sequential #HCR and 3D imaging in zebrafish larvae to reveal spatial expression of numerous mRNAs in the same specimen. Data from these imaging data sets are then computationally analyzed for spatial cell groups, spatially variable genes, and differentially expressed genes along 3D.
We are leveraging this systems-level SGA to uncover unappreciated mechanistic insight at the cell and tissue levels into #ENS construction. Stay tuned for our work that exploits this pipeline within various mutant and perturbation conditions. Reach out if you are interested in trying this! #fruitypebbles
NEW 🚨 Submit to the “Enteric Nervous System Development and Repair” focus issue by October 31, 2026! Guest editors: Julia Ganz and @uribelabrice. Learn more: https://t.co/JbOM6EWRVz #devbio#differentiation
In vivo evidence that full-length Slits have biologically distinct activities compared to the proteolytic fragments. Cultured DRG axons branch in response to Slit2-N and this is opposed by Slit2-FL. In vivo, Slit2-N appears to promote fasciculation, not repulsion.
How animals sense Earth’s magnetic field is one of biology’s enduring mysteries.
Researchers in Science have now identified superparamagnetic macrophages in the livers of rock pigeons to be crucial for magnetic sensing. The finding uncovers an unexpected role for immune cells in sensory perception and may fundamentally change our understanding of animal navigation.
Learn more in this week's issue: https://t.co/JS9qBFZHcP
How animals sense Earth’s magnetic field is one of biology’s enduring mysteries.
Researchers in Science have now identified superparamagnetic macrophages in the livers of rock pigeons to be crucial for magnetic sensing. The finding uncovers an unexpected role for immune cells in sensory perception and may fundamentally change our understanding of animal navigation.
Learn more in this week's issue: https://t.co/JS9qBFZHcP
@uribelabrice This is a meaningful tribute to someone who clearly had a lasting impact on mathematics and on expanding opportunity in STEM. His legacy in both research and advocacy is significant and far reaching.
So very sad to learn of the passing of the incredible Prof. Richard Tapia, an accomplished scientist and true icon in spreading opportunity in STEM fields. https://t.co/rxoh2UP96I Richard changed so many lives, both on an individual basis, and at scale through his relentless drive to inspire minority students and provide them the education and opportunities they needed. I was thrilled when we recognized him as University Professor in 2005, but even greater accolades followed, including the National Medal of Science. I didn't always agree with Richard, but I always listened knowing his brilliance and extraordinary devotion to helping others. My heart hopes that he and his wife Jean, a dancer who became disabled and to whom he was so devoted, are reunited.
Article from "Splicing in Development and Disease": Evan C. Brooks, Charles W. Griffin, and Katherine A. Fantauzzo review the roles of RNA-bidning protein SRSF3 in development and cellular differentiation. Learn more: https://t.co/zUSVU30mm2 @ecbrooks96@Fantauzzo_Lab
Basal bodies (BBs) are what eventually become motile cilia. So, if they don't get positioned correctly on the apical surface, the whole tissue level function can go wrong → ciliopathies. We know actin is involved… but how does it actually control this process? 🤔 (3/17)
Please check out my interview on the Out of Patients Podcast with Oliver Bogler. We chatted about the hidden curriculum and my experience starting @ucdavis, feeling like I was failing, and being supported by Life Science Editors Foundation. https://t.co/XgRzmbNf1A
Live on bioRxiv! We @BhaduriLab use perturb-seq in human cortical tissues to make sense of the shifting molecular trajectories that form the human prefrontal cortex. (1/7)
https://t.co/M6xe66i43y
But why would you ever study something that happens in fish? Because discovering how other animals protect themselves can potentially be beneficial for humans in the long run.
But why would you ever study something that happens in fish? Because discovering how other animals protect themselves can potentially be beneficial for humans in the long run.
Genetically altered bacteria can synthesise gadusol, a naturally occurring compound found in zebrafish eggs that could be developed as an alternative to existing sunscreen products that can harm marine life https://t.co/JaInjZsZ6H